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  1. Investigations of colorectal carcinogenesis have mainly focused on examining neoplastic tissue. With our aim of identifying potentially cancer-predisposing molecular compositions, we chose a different approach...

    Authors: Christian Hunnicke Petersen, Badar Mahmood, Christoffer Badsted, Tina Dahlby, Hanne Borger Rasmussen, Mark Berner Hansen and Niels Bindslev
    Citation: BMC Cancer 2019 19:643
    Content type: Research article Published on:

  2. In the management of patients with RAS wild-type metastatic colorectal cancer (mCRC), anti-epidermal growth factor receptor (EGFR) therapies have demonstrated a clinical benefit, with longer survival. However, th...

    Authors: Shang-Hung Chen, Hsiang-Lin Tsai, Jeng-Kai Jiang, Yung-Chuan Sung, Ching-Wen Huang, Yu-Min Yeh, Li-Tzong Chen and Jaw-Yuan Wang
    Citation: BMC Cancer 2019 19:640
    Content type: Study protocol Published on:

  3. Muscle-invasive bladder tumors are associated with a high risk of relapse and metastasis even after neoadjuvant chemotherapy and radical cystectomy. Therefore, further therapeutic options are needed and molecu...

    Authors: Lucía Trilla-Fuertes, Angelo Gámez-Pozo, Guillermo Prado-Vázquez, Andrea Zapater-Moros, Mariana Díaz-Almirón, Jorge M. Arevalillo, María Ferrer-Gómez, Hilario Navarro, Paloma Maín, Enrique Espinosa, Álvaro Pinto and Juan Ángel Fresno Vara
    Citation: BMC Cancer 2019 19:636
    Content type: Research article Published on:

  4. Zinc-finger E-box binding homeobox 1 (ZEB-1) plays crucial roles in epithelial-to-mesenchymal transition during tumor carcinogenesis. Published studies have examined the potential value of ZEB-1 as a biomarker...

    Authors: Borong Chen, Baisheng Chen, Zhipeng Zhu, Weipeng Ye, Junjie Zeng, Gang Liu, Shengjie Wang, Jin Gao, Guoxing Xu and Zhengjie Huang
    Citation: BMC Cancer 2019 19:635
    Content type: Research article Published on:

  5. Metastasis is a leading cause of breast cancer mortality. The induction of epithelial-to-mesenchymal transition (EMT) and complex oncogenic signaling is a vital step in the evolution of highly metastatic and t...

    Authors: Jia-Hong Chen, Wen-Chien Huang, Oluwaseun Adebayo Bamodu, Peter Mu-Hsin Chang, Tsu-Yi Chao and Tse-Hung Huang
    Citation: BMC Cancer 2019 19:634
    Content type: Research article Published on:

  6. The recent implementation of PET with prostate specific membrane antigen (PSMA)-specific radiotracers into the clinical practice has resulted in the significant improvement of accuracy in the detection of pros...

    Authors: Heike Endepols, Agnieszka Morgenroth, Boris D. Zlatopolskiy, Philipp Krapf, Johannes Zischler, Raphael Richarz, Sergio Muñoz Vásquez, Bernd Neumaier and Felix M. Mottaghy
    Citation: BMC Cancer 2019 19:633
    Content type: Research article Published on:

  7. A key challenge in phase I trials is maintaining rapid escalation in order to avoid exposing too many patients to sub-therapeutic doses, while preserving safety by limiting the frequency of toxic events. Tradi...

    Authors: Bernard North, Hemant Mahendrakumar Kocher and Peter Sasieni
    Citation: BMC Cancer 2019 19:632
    Content type: Research article Published on:

  8. Mammographic density is one of the strongest risk factors for breast cancer. In the general population, mammographic density can be modified by various exposures; whether this is true for women a strong family...

    Authors: Olivia Moran, Andrea Eisen, Rochelle Demsky, Kristina Blackmore, Julia A. Knight, Seema Panchal, Ophira Ginsburg, Kevin Zbuk, Martin Yaffe, Kelly A. Metcalfe, Steven A. Narod and Joanne Kotsopoulos
    Citation: BMC Cancer 2019 19:631
    Content type: Research article Published on:

  9. Globally, the incidence and mortality rates of gastric cancer are high, and its poor prognosis is closely related to tumor recurrence and metastasis. Therefore, the molecular mechanisms associated with the mig...

    Authors: Yaoyue Qi, Jing Lv, Shihai Liu, Libin Sun, Yixuan Wang, Hui Li, Weiwei Qi and Wensheng Qiu
    Citation: BMC Cancer 2019 19:630
    Content type: Research article Published on:

  10. This study aimed to evaluate the value of chitinase activity in prognosticating the occurrence of metastasis in and prognosis of patients with colorectal cancer (CRC).

    Authors: Zhangfa Song, Engeng Chen, Jun Qian, Jianbin Xu, Gaoyang Cao, Wei Zhou, Fei Wang, Min Chen, Dengyong Xu, Xiaowei Wang, Xiaotong Hu, Zhenyu Ju, Xuefeng Huang and Xiujun Cai
    Citation: BMC Cancer 2019 19:629
    Content type: Research article Published on:

  11. A major barrier to effective treatment of glioblastoma (GBM) is the large intertumoral heterogeneity at the genetic and cellular level. In early phase clinical trials, patient heterogeneity in response to ther...

    Authors: Erlend Skaga, Evgeny Kulesskiy, Artem Fayzullin, Cecilie J. Sandberg, Swapnil Potdar, Aija Kyttälä, Iver A. Langmoen, Aki Laakso, Emília Gaál-Paavola, Markus Perola, Krister Wennerberg and Einar O. Vik-Mo
    Citation: BMC Cancer 2019 19:628
    Content type: Research article Published on:

  12. Despite latest advances in prostate cancer (PCa) therapy, PCa remains the third-leading cause of cancer-related death in European men. Dysregulation of microRNAs (miRNAs), small non-coding RNA molecules with g...

    Authors: Mirjam Kiener, Lanpeng Chen, Markus Krebs, Joël Grosjean, Irena Klima, Charis Kalogirou, Hubertus Riedmiller, Burkhard Kneitz, George N. Thalmann, Ewa Snaar-Jagalska, Martin Spahn, Marianna Kruithof-de Julio and Eugenio Zoni
    Citation: BMC Cancer 2019 19:627
    Content type: Research article Published on:

  13. Sentinel node biopsy (SNB) is the standard procedure for axillary staging in patients with clinically lymph node negative invasive breast cancer. Completion axillary lymph node dissection (c-ALND) may not be n...

    Authors: Shabaz Majid, Lisa Rydén and Jonas Manjer
    Citation: BMC Cancer 2019 19:626
    Content type: Research article Published on:

  14. Chemotherapy may be a valuable treatment option as neoadjuvant treatment for locally advanced penile cancer according to some previous studies, but the rarity of the sample and the Lack of large-scale clinical...

    Authors: Jian Xu, Gang Li, Shi Miao Zhu, Qi Liang Cai, Zhun Wang, Xiong Yang, Hong Tan Zhang and Yuan Jie Niu
    Citation: BMC Cancer 2019 19:625
    Content type: Research article Published on:

  15. Nasopharyngeal carcinoma (NPC) is a malignant disease with an enigmatic etiology. NPC associates with Epstein-Barr virus (EBV) and human papillomaviruses (HPVs), while immunological factors also play a role in...

    Authors: Miia Ruuskanen, Ilmo Leivo, Heikki Minn, Tero Vahlberg, Caj Haglund, Jaana Hagström and Heikki Irjala
    Citation: BMC Cancer 2019 19:624
    Content type: Research article Published on:

  16. A cytotoxic chemotherapeutic regimen is not routinely recommended for frail elderly patients with unresectable colorectal cancer (CRC) because of susceptibility to treatment. Panitumumab is a monoclonal antibo...

    Authors: Tetsuji Terazawa, Takeshi Kato, Masahiro Goto, Daisuke Sakai, Yukinori Kurokawa, Toshio Shimokawa, Yoshihiro Matsubara and Taroh Satoh
    Citation: BMC Cancer 2019 19:623
    Content type: Study protocol Published on:

  18. Noninvasive biomarkers are urgently needed for optimal management of nonalcoholic fatty liver disease (NAFLD) for the prevention of disease progression into nonalcoholic steatohepatitis (NASH) and hepatocellul...

    Authors: Naohiko Nakamura, Etsuro Hatano, Kohta Iguchi, Motohiko Sato, Hiroaki Kawaguchi, Iwao Ohtsu, Takaki Sakurai, Nobuhiro Aizawa, Hiroko Iijima, Shuhei Nishiguchi, Takuya Tomono, Yukihiro Okuda, Seidai Wada, Satoru Seo, Kojiro Taura, Shinji Uemoto…
    Citation: BMC Cancer 2019 19:621
    Content type: Research article Published on:

  19. Following publication of the original article [1], the authors reported the following errors in the article.

    Authors: Edith A. Perez, Sanne Lysbet de Haas, Wolfgang Eiermann, Carlos H. Barrios, Masakazu Toi, Young-Hyuck Im, Pier Franco Conte, Miguel Martin, Tadeusz Pienkowski, Xavier B. Pivot, Howard A. Burris III, Sven Stanzel, Monika Patre and Paul Anthony Ellis
    Citation: BMC Cancer 2019 19:620
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2019 19:517

  21. Ovarian cancer is the most common malignant tumor of the female reproductive tract. Chemoresistance is a major challenge for current ovarian cancer therapy. However, the mechanism underlying epithelial ovarian...

    Authors: Junli Deng, Xupeng Bai, Xiaojie Feng, Jie Ni, Julia Beretov, Peter Graham and Yong Li
    Citation: BMC Cancer 2019 19:618
    Content type: Research article Published on:

  22. Long non-coding RNAs (lncRNAs) represent the majority of cellular transcripts and play pivotal roles in hematopoiesis. However, their clinical relevance in acute myeloid leukemia (AML) and myelodysplastic synd...

    Authors: Huai-Hsuan Huang, Fei-Yun Chen, Wen-Chien Chou, Hsin-An Hou, Bor-Sheng Ko, Chien-Ting Lin, Jih-Luh Tang, Chi-Cheng Li, Ming Yao, Woei Tsay, Szu-Chun Hsu, Shang-Ju Wu, Chien-Yuan Chen, Shang-Yi Huang, Mei-Hsuan Tseng, Hwei-Fang Tien…
    Citation: BMC Cancer 2019 19:617
    Content type: Research article Published on:

  24. A higher density of tumor-infiltrating lymphocytes (TILs) can lead to greater therapeutic effects and improved prognoses in cancer treatment. Similar results have been observed in breast cancer, particularly i...

    Authors: Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira
    Citation: BMC Cancer 2019 19:615
    Content type: Research article Published on:

  25. Malignant pleural effusion (MPE) is a devastating sequela associated with cancer. Talc pleurodesis is a common treatment strategy for MPE but has been estimated to be unsuccessful in up to 20–50% of patients. ...

    Authors: Tim N. Beck, Alexander Y. Deneka, Louis Chai, Colin Kanach, Priya Johal, Nicolas J. Alvarez, Yanis Boumber, Erica A. Golemis and Glenn W. Laub
    Citation: BMC Cancer 2019 19:614
    Content type: Research article Published on:

  26. Hereditary cancer syndromes have inherited germline mutations which predispose to benign and malignant tumors. Understanding of the molecular causes in hereditary cancer syndromes has advanced cancer treatment...

    Authors: Yanting Jiang, Yue Sun, Jiandong Hu, Nan Yu, Hui Liu, Jiankun Fan, Xuelian Ning, Yilan Li, Baogang Liu, Yihua Sun, Jinwei Zhang, Xiaohong Qiu, Songbin Fu, Chunshui Zhou and Hui Xu
    Citation: BMC Cancer 2019 19:613
    Content type: Research article Published on:

  27. Whether chronic inflammation increases prostate cancer risk remains unclear. This study investigated whether chronic inflammatory diseases (CID) or anti-inflammatory medication use (AIM) were associated with p...

    Authors: Kerri Beckmann, Beth Russell, Debra Josephs, Hans Garmo, Christel Haggstrom, Lars Holmberg, Pär Stattin, Mieke Van Hemelrijck and Jan Adolfsson
    Citation: BMC Cancer 2019 19:612
    Content type: Research article Published on:

  28. Treatment of postmenopausal, hormone receptor-positive metastatic breast cancer (MBC) patients varies despite clear therapy guidelines, favoring endocrine treatment (ET). Aim of this study was to analyze persi...

    Authors: Markus Wallwiener, Naiba Nabieva, Manuel Feisst, Tanja Fehm, Johann de Waal, Mahdi Rezai, Bernd Baier, Gerold Baake, Hans-Christian Kolberg, Martin Guggenberger, Mathias Warm, Nadia Harbeck, Rachel Wuerstlein, Jörg-Uwe Deuker, Peter Dall, Barbara Richter…
    Citation: BMC Cancer 2019 19:611
    Content type: Research article Published on:

  29. Sentinel lymph node biopsy (SLNB) is standard staging procedure for nodal status in breast cancer, but lacks therapeutic benefit for patients with benign sentinel nodes. For patients with positive sentinel nod...

    Authors: Looket Dihge, Mattias Ohlsson, Patrik Edén, Pär-Ola Bendahl and Lisa Rydén
    Citation: BMC Cancer 2019 19:610
    Content type: Research article Published on:

  30. Esophageal squamous cell carcinoma (ESCC) is the major subtype of esophageal cancer with high aggressiveness and poor prognosis. There is an urgent need for understanding the molecular mechanism underlying the...

    Authors: Bo Zeng, Xin Zhang, Jingling Zhao, Zhewei Wei, Haoshuai Zhu, Minyi Fu, Dawei Zou, Yanfen Feng, Honghe Luo and Yiyan Lei
    Citation: BMC Cancer 2019 19:609
    Content type: Research article Published on:

  31. Currently, there are three main surgical approaches for resectable esophageal cancer: open transthoracic esophagectomy (OTE), conventional minimally invasive esophagectomy (MIE) and robot-assisted esophagectom...

    Authors: Yang Yang, Xiaobin Zhang, Bin Li, Zhigang Li, Yifeng Sun, Teng Mao, Rong Hua, Yu Yang, Xufeng Guo, Yi He, Hecheng Li, Hezhong Chen and Lijie Tan
    Citation: BMC Cancer 2019 19:608
    Content type: Study protocol Published on:

  32. The NTRK2 genetic locus encodes neurotrophin membrane receptors that play an important role in normal neural tissue plasticity, growth, and survival. One NTRK2-encoded protein is TrkB-FL, which can regulate mu...

    Authors: Yalu Zhou, Saurabh Sinha, Joel L. Schwartz and Guy R. Adami
    Citation: BMC Cancer 2019 19:607
    Content type: Research article Published on:

  33. The prognosis of patients with locally advanced gastric cancer or esophagogastric junction adenocarcinoma is still dismal. There are no standard treatment strategies for these patients. Multidisciplinary team ...

    Authors: Xiaowen Liu, Jiejie Jin, Hong Cai, Hua Huang, Guangfa Zhao, Ye Zhou, Jianghong Wu, Chunyan Du, Ziwen Long, Yantian Fang, Mingze Ma, Guichao Li, Menglong Zhou, Jiliang Yin, Xiaodong Zhu, Ji zhu…
    Citation: BMC Cancer 2019 19:606
    Content type: Study protocol Published on:

  35. The prognosis of bladder urothelial carcinoma (BLCA) varies greatly among patients, and conventional pathological predictors are generally inadequate and often inaccurate to predict the heterogeneous behavior ...

    Authors: Shuxiong Zeng, Anwei Liu, Lihe Dai, Xiaowen Yu, Zhensheng Zhang, Qiao Xiong, Jun Yang, Fei Liu, Jinshan Xu, Yongping Xue, Yinghao Sun and Chuanliang Xu
    Citation: BMC Cancer 2019 19:604
    Content type: Research article Published on:

  36. Circulating tumor cells (CTC) and plasma cell-free RNA (cfRNA) can serve as biomarkers for prognosis and treatment response in lung cancer. One barrier to the selected or routine use of CTCs and plasma cfRNA i...

    Authors: Tim N. Beck, Yanis A. Boumber, Charu Aggarwal, Jianming Pei, Catherine Thrash-Bingham, Patricia Fittipaldi, Ramillya Vlasenkova, Chandra Rao, Hossein Borghaei, Massimo Cristofanilli, Ranee Mehra, Ilya Serebriiskii and R. Katherine Alpaugh
    Citation: BMC Cancer 2019 19:603
    Content type: Research article Published on:

  37. Chemo-resistance is one of the major challenges in the therapy of small cell lung cancer (SCLC). Multiple mechanisms are thought to be involved in chemo-resistance during SCLC treatment, but unfortunately, the...

    Authors: Jinzhi Lai, Hainan Yang, Yanyang Zhu, Mei Ruan, Yayu Huang and Qiuyu Zhang
    Citation: BMC Cancer 2019 19:602
    Content type: Research article Published on:

  38. Breast cancer with pathological non-complete response (non-pCR) after neoadjuvant chemotherapy (NAC) has a worse prognosis. Despite Neo-Bioscore has been validated as an independent prognostic model for breast...

    Authors: Uanderson Resende, César Cabello, Susana Oliveira Botelho Ramalho and Luiz Carlos Zeferino
    Citation: BMC Cancer 2019 19:601
    Content type: Research article Published on:

  39. Podoplanin (PDPN), a transmembrane O-glycoprotein, is up-regulated in many tumors and is involved in tumor metastasis and malignant progression. In previous studies, we generated a functional blocking monoclonal ...

    Authors: Mengqiao Xu, Xia Wang, Yanfang Pan, Xingpeng Zhao, Bin Yan, Changgeng Ruan, Lijun Xia and Yiming Zhao
    Citation: BMC Cancer 2019 19:599
    Content type: Research article Published on:

  40. NANOS3 is a gene conserved throughout evolution. Despite the quite low conservation of Nanos sequences between different organisms and even between Nanos paralogs, their role in germ cell development is remarkabl...

    Authors: Vanessa Andries, Evi De Keuckelaere, Katrien Staes, Tino Hochepied, Joachim Taminau, Kelly Lemeire, Philippe Birembaut, Geert Berx and Frans van Roy
    Citation: BMC Cancer 2019 19:598
    Content type: Research article Published on:

  41. S100A8 and S100A9, two heterodimer-forming members of the S100 family, aberrantly express in a variety of cancer types. However, little is known about the mechanism that regulates S100A8/S100A9 co-expression i...

    Authors: Yunguang Li, Fei Kong, Chang Jin, Enze Hu, Qirui Shao, Jin Liu, Dacheng He and Xueyuan Xiao
    Citation: BMC Cancer 2019 19:597
    Content type: Research article Published on:

  42. Gemcitabine remains a cornerstone in chemotherapy of pancreatic ductal adenocarcinoma (PDAC) despite suboptimal clinical effects that are partly due to the development of chemoresistance. Pancreatic stellate c...

    Authors: Manoj Amrutkar, Monica Aasrum, Caroline S. Verbeke and Ivar P. Gladhaug
    Citation: BMC Cancer 2019 19:596
    Content type: Research article Published on:

  43. Epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations represent approximately 4–12% of EGFR mutations and are generally refractory to the 1st and 2nd generation EGFR tyrosine kinase inhibi...

    Authors: Wenfeng Fang, Yihua Huang, Shaodong Hong, Zhonghan Zhang, Minghui Wang, Jiadi Gan, Wenjing Wang, Honglin Guo, Kai Wang and Li Zhang
    Citation: BMC Cancer 2019 19:595
    Content type: Research article Published on:

  45. Cancer patients with advanced disease routinely exhaust available clinical regimens and lack actionable genomic medicine results, leaving a large patient population without effective treatments options when th...

    Authors: Noah E. Berlow, Rishi Rikhi, Mathew Geltzeiler, Jinu Abraham, Matthew N. Svalina, Lara E. Davis, Erin Wise, Maria Mancini, Jonathan Noujaim, Atiya Mansoor, Michael J. Quist, Kevin L. Matlock, Martin W. Goros, Brian S. Hernandez, Yee C. Doung, Khin Thway…
    Citation: BMC Cancer 2019 19:593
    Content type: Research article Published on:

  46. Pulmonary sarcomatoid carcinoma (SC) consists of both carcinomatous and sarcomatous tumors with high degree of malignancy, rapid progression, and poor prognosis. However, little is known regarding how pulmonar...

    Authors: Jianjun Ge, Bin Yao, Jia Huang, Xue Wu, Hua Bao, Qiuxiang Ou, Yang W. Shao and Jun Chen
    Citation: BMC Cancer 2019 19:592
    Content type: Case report Published on:

  47. This study aimed to evaluate the feasibility and prognostic accuracy of incorporating the number of positive lymph nodes (PLN) into the TNM staging system for non-small cell lung cancer (NSCLC) patients.

    Authors: Xiaoling Shang, Jia Liu, Zhenxiang Li, Jiamao Lin and Haiyong Wang
    Citation: BMC Cancer 2019 19:591
    Content type: Research article Published on:

  48. Research into Philadelphia-negative chronic myeloproliferative neoplasms is heterogeneous. In addition, no systematization of studies of polycythemia vera (PV), essential thrombocythemia (ET) or primary myelof...

    Authors: Mónica Mejía-Ochoa, Paola Andrea Acevedo Toro and Jaiberth Antonio Cardona-Arias
    Citation: BMC Cancer 2019 19:590
    Content type: Research article Published on:

  50. Alterations in protein glycosylation patterns have potentially been targeted for biomarker discovery in a wide range of diseases including cancer. Although there have been improvements in patient diagnosis and...

    Authors: Abrha G. Gebrehiwot, Daniel Seifu Melka, Yimenashu Mamo Kassaye, Tufa Gemechu, Wajana Lako, Hiroshi Hinou and Shin-Ichiro Nishimura
    Citation: BMC Cancer 2019 19:588
    Content type: Research article Published on:

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