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  1. Standardized Nucleic Acid Quantification for SEQuencing (SNAQ-SEQ) is a novel method that utilizes synthetic DNA internal standards spiked into each sample prior to next generation sequencing (NGS) library pre...

    Authors: Daniel J. Craig, Thomas Morrison, Sadik A. Khuder, Erin L. Crawford, Leihong Wu, Joshua Xu, Thomas M. Blomquist and James C. Willey
    Citation: BMC Cancer 2019 19:1081
    Content type: Technical advance Published on:

  2. The upregulated expression of the JAK/STAT pathway promotes tumor growth in Hodgkin lymphoma (HL) and primary mediastinal large B-cell lymphoma (PMBCL). Based on the hypothesis that JAK2 is a therapeutic targe...

    Authors: Seok Jin Kim, Dok Hyun Yoon, Hye Jin Kang, Jung Yong Hong, Ho Sup Lee, Sung Yong Oh, Ho-Jin Shin, Jee Hyun Kong, Jun Ho Yi, Kana Sakamoto, Young Hyeh Ko, Jooryung Huh, Seung-Sook Lee, Kengo Takeuchi, Dong-Yeop Shin, Cheolwon Suh…
    Citation: BMC Cancer 2019 19:1080
    Content type: Research article Published on:

  3. High perioperative morbidity, mortality, and uncertain outcome of surgery in octogenarians with proximal gastric carcinoma (PGC) pose a dilemma for both patients and physicians. We aim to evaluate the risks an...

    Authors: Xuefei Wang, Junjie Zhao, Mark Fairweather, Tingsong Yang, Yihong Sun and Jiping Wang
    Citation: BMC Cancer 2019 19:1079
    Content type: Research article Published on:

  4. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS) not only can promote cancer progression, but also they have recently emerged as mediators of the mucosal immune...

    Authors: Sang Yeon Cho, Sungha Kim, Mi-Ju Son, Gwanghun Kim, Parul Singh, Ha Neul Kim, Hei-Gwon Choi, Heon Jong Yoo, Young Bok Ko, Byung Seok Lee and Hyuk Soo Eun
    Citation: BMC Cancer 2019 19:1078
    Content type: Research article Published on:

  5. BRCA1 associated-protein 1 (BAP1) tumor predisposition syndrome is associated with an increased risk for malignant mesotheliomas, uveal and cutaneous melanomas, renal cell carcinomas, and singular cutaneous lesio...

    Authors: Bianca Costa Soares de Sá, Mariana Petaccia de Macedo, Giovana Tardin Torrezan, Juliana Casagrande Tavoloni Braga, Felipe Fidalgo, Luciana Facure Moredo, Rute Lellis, João Pereira Duprat and Dirce Maria Carraro
    Citation: BMC Cancer 2019 19:1077
    Content type: Case report Published on:

  6. Conflicting results have been reported on the influence of carbohydrates in breast cancer.

    Authors: Tone Hoel Lende, Marie Austdal, Anne Elin Varhaugvik, Ivar Skaland, Einar Gudlaugsson, Jan Terje Kvaløy, Lars A. Akslen, Håvard Søiland, Emiel A. M. Janssen and Jan P. A. Baak
    Citation: BMC Cancer 2019 19:1076
    Content type: Research article Published on:

  7. Radiotherapy failure is a significant clinical challenge due to the development of resistance in the course of treatment. Therefore, it is necessary to further study the radiation resistance mechanism of HCC. ...

    Authors: Ze-Tian Shen, Ying Chen, Gui-Chun Huang, Xi-Xu Zhu, Rui Wang and Long-Bang Chen
    Citation: BMC Cancer 2019 19:1075
    Content type: Research article Published on:

  8. Hypofractionated palliative radiotherapy for metastatic lung cancer patients is frequently used in order to ease pain, to increase bone stability, to treat local mass effects, or to prolong progression-free su...

    Authors: Farastuk Bozorgmehr, Adriane Hommertgen, Johannes Krisam, Felix Lasitschka, Jonas Kuon, Martin Maenz, Peter E. Huber, Laila König, Meinhard Kieser, Juergen Debus, Michael Thomas and Stefan Rieken
    Citation: BMC Cancer 2019 19:1074
    Content type: Study protocol Published on:

  9. To measure changes in four common chemotherapy related side-effects (low energy, stress, nausea and pain) immediately after a single exercise session within the first week after treatment.

    Authors: Anna Johnsson, Ingrid Demmelmaier, Katarina Sjövall, Philippe Wagner, Håkan Olsson and Åsa B. Tornberg
    Citation: BMC Cancer 2019 19:1073
    Content type: Research article Published on:

  10. DNMT3A R882H, a frequent mutation in acute myeloid leukemia (AML), plays a critical role in malignant hematopoiesis. Recent findings suggest that DNMT3A mutant acts as a founder mutation and requires additional g...

    Authors: Xiaodong Shi, Ying Yang, Siqi Shang, Songfang Wu, Weina Zhang, Lijun Peng, Ting Huang, Ruihong Zhang, Ruibao Ren, Jianqing Mi and Yueying Wang
    Citation: BMC Cancer 2019 19:1072
    Content type: Research article Published on:

  11. Although numerous studies have investigated the clinicopathologic and prognostic relevance of mucinous adenocarcinoma (MAC) and signet-ring cell carcinoma (SRCC) compared with classic adenocarcinoma (CA), litt...

    Authors: Hui Sheng, Xiaoli Wei, Minjie Mao, Jincan He, Tianqi Luo, Shilin Lu, Liye Zhou, Zhixin Huang and Anli Yang
    Citation: BMC Cancer 2019 19:1071
    Content type: Research article Published on:

  12. Increase of circulating tumor cells (CTCs) has been found after surgery for various carcinomas but not confirmed for breast cancer, and whether endoscopic surgery confers identical effect to CTCs as open surge...

    Authors: Shichao Li, Wenting Yan, Xinhua Yang, Li Chen, Linjun Fan, Haoxi Liu, Kun Liu, Yi Zhang and Jun Jiang
    Citation: BMC Cancer 2019 19:1070
    Content type: Research article Published on:

  13. The single-nucleotide polymorphism SLC39A6 rs1050631 is strongly implicated in esophageal squamous cell carcinoma, leading us to question whether it may also play a role in gastric adenocarcima (GA).

    Authors: Jian Gao, Wenjun Ren, Chunhong Xiao, Lie Wang, Qiaojia Huang, Zaizhong Zhang, Yuan Dang, Pengcheng Weng, Hui Wang, Xuehong Fang, Minxian Zhuang, Liying Lin and Shaoquan Chen
    Citation: BMC Cancer 2019 19:1069
    Content type: Research article Published on:

  14. Accumulating evidence indicates inherited risk in the aetiology of lung cancer, although smoking exposure is the major attributing factor. Family history is a simple substitute for inherited susceptibility. Pr...

    Authors: Yue I. Cheng, Yun Cui Gan, Dan Liu, Michael P. A. Davies, Wei Min Li and John K. Field
    Citation: BMC Cancer 2019 19:1068
    Content type: Research article Published on:

  16. Three-weekly high-dose cisplatin (100 mg/m2) is considered the standard systemic regimen given concurrently with postoperative or definitive radiotherapy in locally advanced squamous cell carcinoma of the head an...

    Authors: Maurice J. D. L. van der Vorst, Elisabeth C. W. Neefjes, Elisa C. Toffoli, Jolanda E. W. Oosterling-Jansen, Marije R. Vergeer, C. René Leemans, Menno P. Kooistra, Jens Voortman and Henk M. W. Verheul
    Citation: BMC Cancer 2019 19:1066
    Content type: Research article Published on:

  17. Triple negative breast cancer (TNBC) represents 15–20% of breast cancers. Due to its heterogeneity and high rates of relapse, there is a need to optimize treatment efficacy. Platinum chemotherapy is still cont...

    Authors: Jessa Gilda P. Pandy, Joanmarie C. Balolong-Garcia, Mel Valerie B. Cruz-Ordinario and Frances Victoria F. Que
    Citation: BMC Cancer 2019 19:1065
    Content type: Research article Published on:

  19. Prostate cancer is one of the most common cancers in the world. The results of treatment after hypofractionated radiotherapy only have been reported from several small randomized clinical trials. Therefore, we...

    Authors: Wei Guo, Yun-Chuan Sun, Jian-Qiang Bi, Xin-Ying He and Li Xiao
    Citation: BMC Cancer 2019 19:1063
    Content type: Research article Published on:

  21. To reveal roles of reactive oxygen species (ROS) status in chemotherapy resistance and to develop a ROS scoring system for prognosis prediction in ovarian cancer.

    Authors: Chaoyang Sun, Ensong Guo, Bo Zhou, Wanying Shan, Jia Huang, Danhui Weng, Peng Wu, Changyu Wang, Shixuan Wang, Wei Zhang, Qinglei Gao, Xiaoyan Xu, Beibei Wang, Junbo Hu, Ding Ma and Gang Chen
    Citation: BMC Cancer 2019 19:1061
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:210

  22. The computed tomography (CT) features of small solid lung cancers and their changing regularity as they grow have not been well studied. The purpose of this study was to analyze the CT features of solid lung c...

    Authors: Zhi-gang Chu, Yan Zhang, Wang-jia Li, Qi Li, Yi-neng Zheng and Fa-jin Lv
    Citation: BMC Cancer 2019 19:1060
    Content type: Research article Published on:

  23. Long non-coding RNAs (lncRNAs) play a fundamental role in colorectal cancer (CRC) development, however, lncRNA expression profiles in CRC and its precancerous stages remain to be explored. We aimed to study wh...

    Authors: Alexandra Kalmár, Zsófia Brigitta Nagy, Orsolya Galamb, István Csabai, András Bodor, Barnabás Wichmann, Gábor Valcz, Barbara Kinga Barták, Zsolt Tulassay, Peter Igaz and Béla Molnár
    Citation: BMC Cancer 2019 19:1059
    Content type: Research article Published on:

  24. This report illustrates the importance of a detailed history and physical exam and careful analysis of hematologic parameters when diagnosing ITP. This case demonstrates that even with subtle deviations from t...

    Authors: Adam Yan, Laura Erdman, Lillian Sung and Stacey Bernstein
    Citation: BMC Cancer 2019 19:1058
    Content type: Case report Published on:

  26. MYC amplification or overexpression is common in Group 3 medulloblastoma and is associated with the worst prognosis. Recently, protein arginine methyl transferase (PRMT) 5 expression has been closely associate...

    Authors: Nagendra K. Chaturvedi, Sidharth Mahapatra, Varun Kesherwani, Matthew J. Kling, Mamta Shukla, Sutapa Ray, Ranjana Kanchan, Naveenkumar Perumal, Timothy R. McGuire, J. Graham Sharp, Shantaram S. Joshi and Don W. Coulter
    Citation: BMC Cancer 2019 19:1056
    Content type: Research article Published on:

  27. Globally, epidemiological evidence suggests cancer incidence and outcomes among Indigenous peoples are a growing concern. Although historically cancer among First Nations (FN) peoples in Canada was relatively ...

    Authors: Tara C. Horrill, Lindsey Dahl, Esther Sanderson, Garry Munro, Cindy Garson, Carole Taylor, Randy Fransoo, Genevieve Thompson, Catherine Cook, Janice Linton and Annette S. H. Schultz
    Citation: BMC Cancer 2019 19:1055
    Content type: Research article Published on:

  28. Bladder cancer (BC) has become a major worldwide public health issue, especially non-muscle-invasive bladder cancer (NMIBC). A flood of related clinical practice guidelines (CPGs) have emerged; however, the qu...

    Authors: Jing Zhang, Yunyun Wang, Hong Weng, Danqi Wang, Fei Han, Qiao Huang, Tong Deng, Xinghuan Wang and Yinghui Jin
    Citation: BMC Cancer 2019 19:1054
    Content type: Research article Published on:

  29. Pancreatic cancer is characterized by a highly immunosuppressive tumor microenvironment and evasion of immune surveillance. Although programmed cell death 1 receptor (PD-1) blockade has achieved certain succes...

    Authors: Guoping Ding, Tao Shen, Chen Yan, Mingjie Zhang, Zhengrong Wu and Liping Cao
    Citation: BMC Cancer 2019 19:1053
    Content type: Research article Published on:

  31. Local consolidative treatment (LCT) is important for oligometastasis, defined as the restricted metastatic capacity of a tumor. This study aimed to determine the effects and prognostic heterogeneity of LCT in ...

    Authors: Jia-Tao Zhang, Si-Yang Liu, Hong-Hong Yan, Yi-Long Wu, Qiang Nie and Wen-Zhao Zhong
    Citation: BMC Cancer 2019 19:1051
    Content type: Research article Published on:

  32. There has been a sharp rise in the incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) in many countries. Patients with HPV-positive OPSCC have a more favorable pro...

    Authors: Titaporn Nopmaneepaisarn, Napadon Tangjaturonrasme, Worawat Rawangban, Chanida Vinayanuwattikun, Somboon Keelawat and Andrey Bychkov
    Citation: BMC Cancer 2019 19:1050
    Content type: Research article Published on:

  33. Diffuse large B-cell lymphoma (DLBCL) is characterized by its clinical and biological heterogeneity. The clinical prognostic implications of tumor-associated macrophages (TAMs) in DLBCL remain controversial an...

    Authors: Yan-Li Li, Zhi-Hu Shi, Xian Wang, Kang-Sheng Gu and Zhi-Min Zhai
    Citation: BMC Cancer 2019 19:1049
    Content type: Research article Published on:

  34. Most lymph node metastasis (LNM) models for early gastric cancer (EGC) include lymphovascular invasion (LVI) as a predictor. However, LVI must be confirmed by postoperative pathology. In this study, we aimed t...

    Authors: Jian-Xian Lin, Zu-Kai Wang, Wei Wang, Jacopo Desiderio, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Ping Li, Amilcare Parisi, Zhi-Wei Zhou and Chang-Ming Huang
    Citation: BMC Cancer 2019 19:1048
    Content type: Research article Published on:

  35. The application of laparoscopic liver resection (LLR) has expanded rapidly in recent decades. Although multiple authors have reported LLR shows improved safety and efficacy in treating hepatocellular carcinoma...

    Authors: Zi-Yu Wang, Qing-Lian Chen, Ling-Ling Sun, Shu-Ping He, Xiao-Fen Luo, Li-Shuang Huang, Jun-Hai Huang, Cheng-Ming Xiong and Chong Zhong
    Citation: BMC Cancer 2019 19:1047
    Content type: Research article Published on:

  36. Assessment of preoperative general condition to predict postoperative outcomes is important, particularly in older patients who typically suffer from various comorbidities and exhibit impaired functional statu...

    Authors: Yuka Ahiko, Dai Shida, Tomoko Horie, Taro Tanabe, Yasuyuki Takamizawa, Ryohei Sakamoto, Konosuke Moritani, Shunsuke Tsukamoto and Yukihide Kanemitsu
    Citation: BMC Cancer 2019 19:946
    Content type: Research article Published on:

  37. Despite much effort on the treatment of breast cancer over the decades, a great uncertainty regarding the appropriate molecular biomarkers and optimal therapeutic strategy still exists. This research was perfo...

    Authors: Chenjing Zhu, Otilia Menyhart, Balázs Győrffy and Xia He
    Citation: BMC Cancer 2019 19:1046
    Content type: Research article Published on:

  38. Resistance to chemotherapy is one of the major hurdles in current cancer therapy. With the increasing occurrence of drug resistance, a paradigm shift in treatment strategy is required. Recently “medication vac...

    Authors: Divya Niveditha, Harshita Sharma, Syamantak Majumder, Sudeshna Mukherjee, Rajdeep Chowdhury and Shibasish Chowdhury
    Citation: BMC Cancer 2019 19:1045
    Content type: Research article Published on:

  39. The receptor tyrosine kinases (RTKs) play critical roles in the development of cancers. Clear cell renal cell carcinoma (ccRCC) accounts for 75% of the RCC. The previous studies on the RTKs in ccRCCs mainly fo...

    Authors: Qing Zhang, Jian-He Liu, Jing-Li Liu, Chun-Ting Qi, Lei Yan, Yu Chen and Qiang Yu
    Citation: BMC Cancer 2019 19:1044
    Content type: Research article Published on:

  40. Radiological imaging plays a central role in the diagnosis of breast cancer (BC). Some studies suggest MRI techniques like diffusion weighted imaging (DWI) may provide further prognostic value by discriminatin...

    Authors: Alexey Surov, Yun-Woo Chang, Lihua Li, Laura Martincich, Savannah C. Partridge, Jin You Kim and Andreas Wienke
    Citation: BMC Cancer 2019 19:1043
    Content type: Research article Published on:

  42. The ultimate goal of locoregional therapy (LRT) to the liver is to induce total tumor necrosis. Trans-arterial chemoembolization (TACE) is the mainstay bridging therapy for patients with hepatocellular carcino...

    Authors: Wei Zhang, An-Hui Xu, Wei Wang, Yan-Hui Wu, Qian-Ling Sun and Chang Shu
    Citation: BMC Cancer 2019 19:1041
    Content type: Research article Published on:

  43. The longevity for people with intellectual disability (ID) has significantly increased in developed countries during the past decades. Consequently, the incidence of cancer is expected to increase in this grou...

    Authors: Mikael Segerlantz, Anna Axmon, Rebecca Gagnemo Persson, Eva Brun and Gerd Ahlström
    Citation: BMC Cancer 2019 19:1040
    Content type: Research article Published on:

  44. Understanding mechanisms underlying specific chemotherapeutic responses in subtypes of cancer may improve identification of treatment strategies most likely to benefit particular patients. For example, triple-...

    Authors: David P. Hill, Akeena Harper, Joan Malcolm, Monica S. McAndrews, Susan M. Mockus, Sara E. Patterson, Timothy Reynolds, Erich J. Baker, Carol J. Bult, Elissa J. Chesler and Judith A. Blake
    Citation: BMC Cancer 2019 19:1039
    Content type: Research article Published on:

  45. Androgens, through their own receptor, play a protective role on breast tumor development and progression and counterbalance estrogen-dependent growth stimuli which are intimately linked to breast carcinogenesis.

    Authors: Francesca De Amicis, Chiara Chiodo, Catia Morelli, Ivan Casaburi, Stefania Marsico, Rosalinda Bruno, Diego Sisci, Sebastiano Andò and Marilena Lanzino
    Citation: BMC Cancer 2019 19:1038
    Content type: Research article Published on:

  46. SMAD4 is frequently inactivated and associated with a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Abnormal SMAD4 expression also plays an important role in the malignant progression of PDAC.

    Authors: Zusen Wang, Yongxing Li, Shixiong Zhan, Lu Zhang, Shun Zhang, Qian Tang, Miaomiao Li, Zhen Tan, Shiguo Liu and Xiaoming Xing
    Citation: BMC Cancer 2019 19:1037
    Content type: Research article Published on:

  47. The breast cancer microenvironment contributes to tumor progression and response to chemotherapy. Previously, we reported that increased stromal Type X collagen α1 (ColXα1) and low TILs correlated with poor pa...

    Authors: Chaohui Lisa Zhao, Kamaljeet Singh, Alexander S. Brodsky, Shaolei Lu, Theresa A. Graves, Mary Anne Fenton, Dongfang Yang, Ashlee Sturtevant, Murray B. Resnick and Yihong Wang
    Citation: BMC Cancer 2019 19:1036
    Content type: Research article Published on:

  48. β-arrestin-2(Arr2) functions as an anti-apoptotic factor and affects cell proliferation, but its downstream molecular pathway in endometrial carcinoma (EC) is still unclear. This study aimed to investigate the...

    Authors: Fanling Hong, Yujun Zhang, Wenjin Cheng, Xiuli Sun and Jianliu Wang
    Citation: BMC Cancer 2019 19:1035
    Content type: Research article Published on:

  49. Infusion of high-dose intravenous methotrexate (MTX) has been demonstrating to penetrate the blood-brain barrier. The aim of this present study was to assess the efficacy and safety of high dose MTX in patient...

    Authors: F. Bazan, E. Dobi, B. Royer, E. Curtit, L. Mansi, N. Menneveau, M. J. Paillard, G. Meynard, C. Villanueva, X. Pivot and L. Chaigneau
    Citation: BMC Cancer 2019 19:1029
    Content type: Research article Published on:

  50. Women with ovarian cancer can present with a variety of symptoms and signs, and an increasing range of tests are available for their investigation. A number of international guidelines provide advice for the i...

    Authors: Garth Funston, Marije Van Melle, Marie-Louise Ladegaard Baun, Henry Jensen, Charles Helsper, Jon Emery, Emma J. Crosbie, Matthew Thompson, Willie Hamilton and Fiona M. Walter
    Citation: BMC Cancer 2019 19:1028
    Content type: Research article Published on:

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