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  1. Many cancers are preventable through lifestyle modification; however, few adults engage in behaviors that are in line with cancer prevention guidelines. This may be partly due to the mixed messages on effectiv...

    Authors: Sarah E. Neil-Sztramko, Emily Belita, Anthony J. Levinson, Jennifer Boyko and Maureen Dobbins
    Citation: BMC Cancer 2019 19:1138
    Content type: Research article Published on:

  2. Early recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is associated with poor surgical outcomes. This study aims to construct a preoperative model to predict individual risk of po...

    Authors: Abdulahad Abdulrab Mohammed Al-Ameri, Xuyong Wei, Lidan Lin, Zhou Shao, Haijun Guo, Haiyang Xie, Lin Zhou, Shusen Zheng and Xiao Xu
    Citation: BMC Cancer 2019 19:1136
    Content type: Research article Published on:

  3. Vasculogenic mimicry (VM) a microvascular system consisting of non-endothelial cells that is newly formed by aggressive tumors, has been proposed as an important therapeutic target in malignant melanoma (MM). ...

    Authors: Zhenhua Zhang, Saber Imani, Marzieh Dehghan Shasaltaneh, Hossein Hosseinifard, Linglin Zou, Yu Fan and Qinglian Wen
    Citation: BMC Cancer 2019 19:1134
    Content type: Research article Published on:

  4. Non-muscle-invasive bladder cancer (NMIBC) is the most common neoplasm of the urinary tract and requires life-long invasive surveillance to detect disease recurrence. Currently, there are no effective oral the...

    Authors: Remco J. Molenaar, Jons W. van Hattum, Iris S. Brummelhuis, Jorg R. Oddens, C. Dilara Savci-Heijink, Egbert R. Boevé, Saskia A. van der Meer, J. Fred Witjes, Michael N. Pollak, Theo M. de Reijke and Johanna W. Wilmink
    Citation: BMC Cancer 2019 19:1133
    Content type: Study protocol Published on:

  5. Operable breast cancer patients may experience late recurrences because of reactivation of dormant tumor cells within the bone marrow (BM). Identification of patients who would benefit from extended therapy is...

    Authors: Kjersti Tjensvoll, Oddmund Nordgård, Maren Skjæveland, Satu Oltedal, Emiel A. M. Janssen and Bjørnar Gilje
    Citation: BMC Cancer 2019 19:1131
    Content type: Research article Published on:

  7. TAE-gene therapy for hepatoma, incorporating the tumor-targeted therapeutic efficacy of trans-arterial embolization, hydroxyapatite nanoparticles (nHAP) and anti-cancer wild-type p53 gene (wt-p53), was present...

    Authors: Gaopeng Li, Wenqin Kang, Mingliang Jin, Lidong Zhang, Jian Zheng, Kai Jia, Jinfeng Ma, Ting Liu, Xueyi Dang, Zhifeng Yan, Zefeng Gao and Jun Xu
    Citation: BMC Cancer 2019 19:1126
    Content type: Research article Published on:

  8. Chemotherapy can improve the survival of patients with advanced gastric cancer. However, whether triplet chemotherapy can further improve the survival of patients with advanced gastric cancer compared with dou...

    Authors: Xinjian Guo, Fuxing Zhao, Xinfu Ma, Guoshuang Shen, Dengfeng Ren, Fangchao Zheng, Feng Du, Ziyi Wang, Raees Ahmad, Xinyue Yuan, Junhui Zhao and Jiuda Zhao
    Citation: BMC Cancer 2019 19:1125
    Content type: Research article Published on:

  9. Testicular germ cell cancer (TGCC) develops from pre-malignant germ neoplasia in situ (GCNIS) cells. GCNIS originates from fetal gonocytes (POU5F1+/MAGE-A4−), which fail to differentiate to pre-spermatogonia (POU...

    Authors: Maria E. Camacho-Moll, Joni Macdonald, L. H. J. Looijenga, Michael P. Rimmer, Roland Donat, John A. Marwick, C. J. Shukla, Neil Carragher, Anne Jørgensen and Rod T. Mitchell
    Citation: BMC Cancer 2019 19:1124
    Content type: Research article Published on:

  10. The rs2057482 polymorphism in the hypoxia inducible factor 1 subunit alpha (HIF1A) gene has been reported to be associated with a risk of several types of cancer, but this association has not yet been definitivel...

    Authors: Li-Fang Wu, Gui-Ping Xu, Qing Zhao, Li-Jing Zhou, Ding Wang and Wei-Xian Chen
    Citation: BMC Cancer 2019 19:1123
    Content type: Research article Published on:

  11. To assess the efficacy of Nimotuzumab in combination with first-line chemoradiotherapy treatment in Chinese patients with primary III-IVb stage nasopharyngeal carcinoma.

    Authors: Wang Zhi-Qiang, Mei Qi, Li Ji-Bin, You Rui, Liu You-Ping, Sun Rui, Hu Guang-Yuan, Chen Ming-Yuan and Hua Yi-Jun
    Citation: BMC Cancer 2019 19:1122
    Content type: Research article Published on:

  12. High grade serous ovarian carcinoma (HGSOC) is the most common subtype of epithelial ovarian cancers (EOC) with poor prognosis. In most cases EOC is widely disseminated at the time of diagnosis. Despite the op...

    Authors: H. Sallinen, S. Janhonen, P. Pölönen, H. Niskanen, O. H. Liu, A. Kivelä, J. M. Hartikainen, M. Anttila, M. Heinäniemi, S. Ylä-Herttuala and M. U. Kaikkonen
    Citation: BMC Cancer 2019 19:1121
    Content type: Research article Published on:

  13. Kidney transplantation (KT) correlates with an increased risk of developing several malignancies; however, the risk of colorectal cancer (CRC) after KT remains debatable and has been marginally explored. Hence...

    Authors: Han-En Wang, Yu-Chan Liao, Je-Ming Hu, Wen-Chih Wu, Wan-Yun Chou, Yong-Chen Chen, Yu-Ching Chou, Chi-Feng Hung, Yu-Feng Tian, San-Lin You and Chien-An Sun
    Citation: BMC Cancer 2019 19:1120
    Content type: Research article Published on:

  14. Intracranial metastasis of Gastrointestinal Stromal Tumors (GISTs) is rare but presents unique treatment challenges. We present a case of intracranial metastasis of GIST with a systematic review of the literat...

    Authors: Marc Prablek, Visish M. Srinivasan, Aditya Srivatsan, Stephanie Holdener, Mazen Oneissi, Kent A. Heck, Ali Jalali, Jacob Mandel, Ashwin Viswanathan and Akash J. Patel
    Citation: BMC Cancer 2019 19:1119
    Content type: Case report Published on:

  15. Chemotherapy-induced nausea and vomiting (CINV) belong among the most burdensome side effects in hemato-oncology. Mostly, a combination of ondansetron and dexamethasone is used as antiemetic prophylaxis in ped...

    Authors: Semjon Willier, Karin Melanie Cabanillas Stanchi, Martina von Have, Vera Binder, Franziska Blaeschke, Judith Feucht, Tobias Feuchtinger and Michaela Döring
    Citation: BMC Cancer 2019 19:1118
    Content type: Research article Published on:

  16. The CAO/ARO/AIO-94 demonstrated that neoadjuvant chemoradiotherapy (CRT) could decrease the rate of local recurrence rather than distal metastases in advanced rectal cancer. Adjuvant chemotherapy (ACT) can eli...

    Authors: Qingguo Li, Dakui Luo, Ji Zhu, Lifeng Yang, Qi Liu, Yanlei Ma, Lei Liang, Sanjun Cai, Zhen Zhang and Xinxiang Li
    Citation: BMC Cancer 2019 19:1117
    Content type: Study protocol Published on:

  17. Glioma is a common malignant tumours in the central nervous system (CNS), that exhibits high morbidity, a low cure rate, and a high recurrence rate. Currently, immune cells are increasingly known to play roles...

    Authors: Qiu-Yue Zhong, Er-Xi Fan, Guang-Yong Feng, Qi-Ying Chen, Xiao-Xia Gou, Guo-Jun Yue and Gui-hai Zhang
    Citation: BMC Cancer 2019 19:1116
    Content type: Database Published on:

  18. The aim was to investigate the prognostic value of MR apparent diffusion coefficients (ADC) using histogram analysis (HA) in predicting disease-free survival (DFS) of cervical cancer after chemo-radiation ther...

    Authors: Bo Zhao, Kun Cao, Xiao-Ting Li, Hai-Tao Zhu and Ying-Shi Sun
    Citation: BMC Cancer 2019 19:1115
    Content type: Research article Published on:

  19. We investigated the association of LHR expression in epithelial ovarian cancer (OC) with clinical and pathologic characteristics of patients. LHR expression was examined immunohistochemically using tissue micr...

    Authors: Shigang Xiong, Paulette Mhawech-Fauceglia, Denice Tsao-Wei, Lynda Roman, Rajesh K. Gaur, Alan L. Epstein and Jacek Pinski
    Citation: BMC Cancer 2019 19:1114
    Content type: Research article Published on:

  20. Following publication of the original article [1], the authors have re-evaluated the authorship for this article. The updated author group is:

    Authors: Ho-Keun Kwon, Ji-Sun Hwang, Jae-Seon So, Choong-Gu Lee, Anupama Sahoo, Jae-Ha Ryu, Won Kyung Jeon, Byoung Seob Ko, Sung Haeng Lee, Zee Yong Park and Sin-Hyeog Im
    Citation: BMC Cancer 2019 19:1113
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2010 10:392

  21. Osteosarcoma (OS) is a malignancy of the bone that has no clearly identified prognostic factors for diagnosis. In this study, we evaluated the regulatory role of long non-coding RNA (lncRNA) ANCR on the migrat...

    Authors: Bo Liu, Hongyan Zhao, Lili Zhang and Xuefeng Shi
    Citation: BMC Cancer 2019 19:1112
    Content type: Research article Published on:

  23. The majority of patients with head and neck squamous cell carcinoma (HNSCC) receive bilateral elective nodal irradiation (ENI), in order to reduce the risk of regional failure. Bilateral ENI, as compared to un...

    Authors: Pieter D. de Veij Mestdagh, Willem H. Schreuder, Wouter V. Vogel, Maarten L. Donswijk, Eric van Werkhoven, Jacqueline E. van der Wal, Richard Dirven, Baris Karakullukcu, Jan-Jakob Sonke, Michiel W. M. van den Brekel, Corrie A. M. Marijnen and Abrahim Al-Mamgani
    Citation: BMC Cancer 2019 19:1110
    Content type: Study protocol Published on:

  24. Circulating tumour DNA (ctDNA) has emerged as a promising blood-based biomarker for monitoring disease status of patients with advanced cancers. The presence of ctDNA in the blood is a result of biological pro...

    Authors: Leslie Calapre, Lydia Warburton, Michael Millward and Elin S. Gray
    Citation: BMC Cancer 2019 19:1109
    Content type: Case report Published on:

  25. To explore the patterns of failures and areas at highest risk of recurrence for postoperative intrahepatic cholangiocarcinoma (IHCC), with the aim to guide IHCC adjuvant radiotherapy.

    Authors: Wei Yu, Chunxiu Hu, Yongjie Shui, Kui Wu, Lili Zhang, Ying Chen, Chao Li, Jing Xu and Qichun Wei
    Citation: BMC Cancer 2019 19:1108
    Content type: Research article Published on:

  26. Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant inherited condition affecting multiple endocrine organs, resulting in significant morbidity and decreased life expectancy. Early tumor id...

    Authors: Lei Lou, Lixia Zhou, Wenyan Wang, Huina Li and Yuehong Li
    Citation: BMC Cancer 2019 19:1107
    Content type: Case report Published on:

  27. Chemoresistance is an obstacle to the successful treatment of nasopharyngeal carcinoma (NPC). Lapatinib is a targeted tyrosine kinase inhibitor therapeutic drug also used to treat NPC, but high doses are often...

    Authors: Sathid Aimjongjun, Zimam Mahmud, Yannasittha Jiramongkol, Glowi Alasiri, Shang Yao, Ernesto Yagüe, Tavan Janvilisri and Eric W.-F. Lam
    Citation: BMC Cancer 2019 19:1106
    Content type: Research article Published on:

  28. The prevalence of both atrial fibrillation (AF) and malignancies are increasing in the elderly, but incidences of new onset AF in different cancer subtypes are not well described.The objectives of this study w...

    Authors: Christina Boegh Jakobsen, Morten Lamberts, Nicholas Carlson, Morten Lock-Hansen, Christian Torp-Pedersen, Gunnar H. Gislason and Morten Schou
    Citation: BMC Cancer 2019 19:1105
    Content type: Research article Published on:

  29. The relationship between whole brain radiotherapy (WBRT) dose with intracranial tumor control and overall survival (OS) in patients with non-small cell lung cancer (NSCLC) brain metastases (BM) is largely unkn...

    Authors: Zhensheng Li, Dongxing Shen, Jian Zhang, Jun Zhang, Fang Yang, Deyou Kong, Jie Kong and Andu Zhang
    Citation: BMC Cancer 2019 19:1104
    Content type: Research article Published on:

  30. Recently, a growing number of studies have reported the coorelation between miR-155 and the diagnosis and prognosis of lung cancer, but results of these researches were still controversial due to insufficient ...

    Authors: Chuchu Shao, Fengming Yang, Zhiqiang Qin, Xinming Jing, Yongqian Shu and Hua Shen
    Citation: BMC Cancer 2019 19:1103
    Content type: Research article Published on:

  31. The combination of nivolumab, a programmed death-1 (PD-1) targeted monoclonal antibody, with the cytotoxic T-lymphocyte antigen-4 (CTLA-4) targeted antibody, ipilimumab, represents a new standard of care in th...

    Authors: Hannah L. Buckley, Fiona J. Collinson, Gemma Ainsworth, Heather Poad, Louise Flanagan, Eszter Katona, Helen C. Howard, Geraldine Murden, Rosamonde E. Banks, Joanne Brown, Galina Velikova, Tom Waddell, Kate Fife, Paul D. Nathan, James Larkin, Thomas Powles…
    Citation: BMC Cancer 2019 19:1102
    Content type: Study protocol Published on:

  32. The prognostic relevance of circulating tumour cells (CTCs) in metastatic breast cancer (MBC) patients has been confirmed by several clinical trials. However, predictive blood-based biomarkers for stratificati...

    Authors: Natalia Krawczyk, Melissa Neubacher, Franziska Meier-Stiegen, Hans Neubauer, Dieter Niederacher, Eugen Ruckhäberle, Svjetlana Mohrmann, Jürgen Hoffmann, Thomas Kaleta, Malgorzata Banys-Paluchowski, Petra Reinecke, Irene Esposito, Wolfgang Janni and Tanja Fehm
    Citation: BMC Cancer 2019 19:1101
    Content type: Research article Published on:

  33. This study aimed to assess the effect of antibiotics on the clinical outcomes of patients with solid cancers undergoing treatment with immune checkpoint inhibitors (ICIs).

    Authors: Hyunho Kim, Ji Eun Lee, Sook Hee Hong, Myung Ah. Lee, Jin Hyoung Kang and In-Ho Kim
    Citation: BMC Cancer 2019 19:1100
    Content type: Research article Published on:

  34. There are differences in the quality of care among breast cancer patients. Narrowing the quality differences could be achieved by increasing the utilization rate of indicators. Here we explored key indicators ...

    Authors: Chao Wang, Xi Li, Shaofei Su, Xinyu Wang, Jingkun Li, Xiaoqiang Bao and Meina Liu
    Citation: BMC Cancer 2019 19:1099
    Content type: Research article Published on:

  36. Adapting screening strategy to colorectal cancer (CRC) risk may improve efficiency for all stakeholders however limited tools for such risk stratification exist. Colorectal cancers usually evolve from advanced...

    Authors: Laura W. Musselwhite, Thomas S. Redding IV, Kellie J. Sims, Meghan C. O’Leary, Elizabeth R. Hauser, Terry Hyslop, Ziad F. Gellad, Brian A. Sullivan, David Lieberman and Dawn Provenzale
    Citation: BMC Cancer 2019 19:1097
    Content type: Research article Published on:

  37. The aim of this study was to assess the agreement rate between intraoperative evaluation (IOE) and final diagnosis (FD) in a series of surgically resected endometrial carcinoma (EC), with a preoperative ambigu...

    Authors: A. Santoro, A. Piermattei, F. Inzani, G. Angelico, M. Valente, D. Arciuolo, S. Spadola, M. Martini, F. Fanfani, A. Fagotti, V. Gallotta, G. Scambia and G. F. Zannoni
    Citation: BMC Cancer 2019 19:1096
    Content type: Research article Published on:

  38. Circulating extracelluar vesicles (EVs) in epithelial ovarian cancer (EOC) patients emanate from multiple cells. These EVs are emerging as a new type of biomarker as they can be obtained by non-invasive approa...

    Authors: Wei Zhang, Peng Peng, Xiaoxuan Ou, Keng Shen and Xiaohua Wu
    Citation: BMC Cancer 2019 19:1095
    Content type: Research article Published on:

  39. The incidence of papillary thyroid carcinoma (PTC) has been increasing worldwide in recent years. Therefore, novel potential therapeutic targets for PTC are urgently needed. Enhancer of zeste homolog 2 (EZH2),...

    Authors: Liqiong Xue, Hongzhu Yan, Ying Chen, Qifa Zhang, Xin Xie, Xiaoying Ding, Xiaojing Wang, Zhongqing Qian, Feng Xiao, Zhiyi Song, Yijie Wu, Yongde Peng and Huanbai Xu
    Citation: BMC Cancer 2019 19:1094
    Content type: Research article Published on:

  41. The evasion of apoptosis is a hallmark of cancer. Understanding this process holistically and overcoming apoptosis resistance is a goal of many research teams in order to develop better treatment options for c...

    Authors: Manuela Salvucci, Zaitun Zakaria, Steven Carberry, Amanda Tivnan, Volker Seifert, Donat Kögel, Brona M. Murphy and Jochen H. M. Prehn
    Citation: BMC Cancer 2019 19:1092
    Content type: Review Published on:

  42. The features and survival of stage IV breast cancer patients with different metastatic sites are poorly understood. This study aims to examine the clinicopathological features and survival of stage IV breast c...

    Authors: Ru Wang, Yayun Zhu, Xiaoxu Liu, Xiaoqin Liao, Jianjun He and Ligang Niu
    Citation: BMC Cancer 2019 19:1091
    Content type: Research article Published on:

  43. We designed a retrospective study to compare prognostic outcomes based on whether or not surgical resection was performed in elderly patients aged(≥75 years) with resectable pancreatic cancer.

    Authors: Hyeong Min Park, Sang-Jae Park, Sung-Sik Han and Seoung Hoon Kim
    Citation: BMC Cancer 2019 19:1090
    Content type: Research article Published on:

  44. Abnormal autocrine fibroblast growth factor 19 (FGF19) production has been observed in several types of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the potential of serum ...

    Authors: Takahiro Maeda, Hiroaki Kanzaki, Tetsuhiro Chiba, Junjie Ao, Kengo Kanayama, Susumu Maruta, Yuko Kusakabe, Tomoko Saito, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Sadahisa Ogasawara, Eiichiro Suzuki, Yoshihiko Ooka, Shingo Nakamoto, Ryo Nakagawa…
    Citation: BMC Cancer 2019 19:1088
    Content type: Research article Published on:

  45. SOX2 is regarded as an important marker in stem cell. The change of SOX2 expression after adjuvant therapy in high grade glioma (HGG) remains unknown so far. Few patients with recurrent glioma have opportunity...

    Authors: Wei Yu, Xiaoqiu Ren, Chunxiu Hu, Yinuo Tan, Yongjie Shui, Zexin Chen, Lili Zhang, Jiaping Peng and Qichun Wei
    Citation: BMC Cancer 2019 19:1087
    Content type: Research article Published on:

  47. Cytokeratin 7 (CK7) and GATA binding protein 3 (GATA3) are considered as immunohistochemical hallmarks of breast cancers; however, there are breast tumors lacking these markers. Clinicopathological characteriz...

    Authors: Shaolei Lu, Evgeny Yakirevich, Li Juan Wang, Murray B. Resnick and Yihong Wang
    Citation: BMC Cancer 2019 19:1085
    Content type: Research article Published on:

  48. Elevated red blood cell distribution width (RDW) and decreased platelet count (PLT) can be clinically relevant to the prognosis in cancer patients. However, their prognostic values in patients with diffuse lar...

    Authors: Manman Li, Hailong Xia, Huimin Zheng, Yafeng Li, Jun Liu, Linhui Hu, Jingrong Li, Yangyang Ding, Lianfang Pu, Qianle Gui, Yijie Zheng, Zhimin Zhai and Shudao Xiong
    Citation: BMC Cancer 2019 19:1084
    Content type: Research article Published on:

  49. Hepatoma-derived growth factor (HDGF) participates in angiogenesis and represents a negative prognostic factor in oral cancer. The current study was designed to elucidate the regulatory mechanism between HDGF ...

    Authors: Yu-Wei Lin, Shih-Tsung Huang, Jian-Ching Wu, Tian-Huei Chu, Shih-Chung Huang, Ching-Chih Lee and Ming-Hong Tai
    Citation: BMC Cancer 2019 19:1083
    Content type: Research article Published on:

  50. It remains controversial whether weight change could influence the risks of colorectal cancer (CRC) and mortality. This study aimed to quantify the associations between full-spectrum changes in body mass index...

    Authors: Ji-Bin Li, Sheng Luo, Martin C. S. Wong, Cai Li, Li-Fen Feng, Jian-Hong Peng, Jing-Hua Li and Xi Zhang
    Citation: BMC Cancer 2019 19:1082
    Content type: Research article Published on:

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