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  2. To determine safety and efficacy of radiofrequency ablation (RFA) for local treatment of lung metastases of renal cell carcinoma (RCC), sequenced or combined with systemic treatments.

    Authors: Alexis Gonnet, Laura Salabert, Guilhem Roubaud, Vittorio Catena, Véronique Brouste, Xavier Buy, Marine Gross Goupil, Alain Ravaud and Jean Palussière
    Citation: BMC Cancer 2019 19:1182
    Content type: Research article Published on:

  3. While colorectal cancer (CRC) patients with localized disease have a favorable prognosis, the five-year-survival rate in patients with distant spread is still below 15%. Hence, a detailed understanding of the ...

    Authors: Sarah Weber, Sebastian E. Koschade, Christopher M. Hoffmann, Taronish D. Dubash, Klara M. Giessler, Sebastian M. Dieter, Friederike Herbst, Hanno Glimm and Claudia R. Ball
    Citation: BMC Cancer 2019 19:1181
    Content type: Research article Published on:

  4. Interleukin-6 (IL-6) is commonly highly secreted in the breast cancer (BrCA) microenvironment and implicated in disease development. In this study, we aimed to determine the role of the IL-6/pSTAT3/HIC1 axis i...

    Authors: Xueqing Sun, Qing Qu, Yimin Lao, Mi Zhang, Xiaoling Yin, Huiqin Zhu, Ying Wang, Jie Yang, Jing Yi and Mingang Hao
    Citation: BMC Cancer 2019 19:1180
    Content type: Research article Published on:

  5. Some historic breakthroughs have been made in immunotherapy of advanced cancer. However, there is still little research on immunotherapy in prostate cancer. We explored the relationship between immune cell inf...

    Authors: Xin Rui, Siliang Shao, Li Wang and Jiangyong Leng
    Citation: BMC Cancer 2019 19:1179
    Content type: Research article Published on:

  6. Previous studies have suggested that lymphoma survivors commonly display altered Health-Related Quality of Life (HRQoL). Because these were predominantly cross-sectional studies, the dynamic of events as well ...

    Authors: Gisèle Compaci, Cécile Conte, Lucie Oberic, Loïc Ysebaert, Guy Laurent and Fabien Despas
    Citation: BMC Cancer 2019 19:1178
    Content type: Research article Published on:

  7. Following publication of the original article [1], the authors reported an omission in the affiliations.

    Authors: Shereen El-Mashed, Tracey R. O’Donovan, Elaine W. Kay, Ayat R. Abdallah, Mary-Clare Cathcart, Jacintha O’Sullivan, Anthony O’Grady, John Reynolds, Seamus O’Reilly, Gerald C. O’Sullivan and Sharon L. McKenna
    Citation: BMC Cancer 2019 19:1177
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2015 15:582

  8. Deciphering the meaning of the human DNA is an outstanding goal which would revolutionize medicine and our way for treating diseases. In recent years, non-coding RNAs have attracted much attention and shown to...

    Authors: Johannes Smolander, Alexey Stupnikov, Galina Glazko, Matthias Dehmer and Frank Emmert-Streib
    Citation: BMC Cancer 2019 19:1176
    Content type: Research Article Published on:

  9. Pancreatic ductal adenocarcinoma (PDAC) is considered as one of the most aggressive cancers lacking efficient early detection biomarkers. Circulating miRNAs are now being considered to have potency to be used ...

    Authors: Bishnupriya Chhatriya, Moumita Mukherjee, Sukanta Ray, Piyali Sarkar, Shatakshee Chatterjee, Debashis Nath, Kshaunish Das and Srikanta Goswami
    Citation: BMC Cancer 2019 19:1175
    Content type: Research article Published on:

  10. The prognoses of head and neck squamous cell carcinoma (HNSCC) and esophageal squamous cell carcinoma (ESCC) are poor, especially when both tumors occur at the same time. We examined the clonal relatedness of ...

    Authors: Somkiat Sunpaweravong, Sacarin Bunbanjerdsuk, Tanjitti Pongrujikorn, Chaiwat Naktang, Patrapim Sunpaweravong, Anupong Nitiruangjaras, Tanadech Dechaphankul and Natini Jinawath
    Citation: BMC Cancer 2019 19:1174
    Content type: Research article Published on:

  11. Locally advanced breast cancer often undergoes neoadjuvant chemotherapy (NAC), which allows in vivo evaluation of the therapeutic response. The determination of the pathological complete response (pCR) is one ...

    Authors: Wilson Eduardo Furlan Matos Alves, Murilo Bonatelli, Rozany Dufloth, Lígia Maria Kerr, Guilherme Freire Angotti Carrara, Ricardo Filipe Alves da Costa, Cristovam Scapulatempo-Neto, Daniel Tiezzi, René Aloísio da Costa Vieira and Céline Pinheiro
    Citation: BMC Cancer 2019 19:1173
    Content type: Research article Published on:

  12. In pediatric sarcomas, outcomes of established therapies still remain poor, especially due to high-grade resistances to chemotherapeutic compounds. Taking novel biological approaches into account, virotherapy ...

    Authors: Chihab Klose, Susanne Berchtold, Marina Schmidt, Julia Beil, Irina Smirnow, Sascha Venturelli, Markus Burkard, Rupert Handgretinger and Ulrich M. Lauer
    Citation: BMC Cancer 2019 19:1172
    Content type: Research article Published on:

  13. Luminal B cancers show much worse outcomes compared to luminal A. This present study aims to screen key lncRNAs and mRNAs correlated with luminal-B breast cancer.

    Authors: Cheng-Liang Yuan, Xiang-Mei Jiang, Ying Yi, Jian-Fei E, Nai-Dan Zhang, Xue Luo, Ning Zou, Wei Wei and Ying-Ying Liu
    Citation: BMC Cancer 2019 19:1171
    Content type: Research article Published on:

  14. Cisplatin is a potent chemotherapeutic agent used to treat a variety of solid tumors. One of the major side effects of cisplatin is dose-limiting nephrotoxicity. We recently demonstrated that the renal uptake ...

    Authors: Satoshi Shoji, Michihiro Hosojima, Hideyuki Kabasawa, Rie Kondo, Satoru Miura, Satoshi Watanabe, Nobumasa Aoki, Ryohei Kaseda, Shoji Kuwahara, Naohito Tanabe, Yoshiaki Hirayama, Ichiei Narita, Toshiaki Kikuchi, Hiroshi Kagamu and Akihiko Saito
    Citation: BMC Cancer 2019 19:1170
    Content type: Research article Published on:

  15. Urokinase plasminogen activator (uPA) is an extracellular matrix-degrading protease that is involved in the invasiveness and progression of cancer. There is good evidence that uPA expression is a clinically re...

    Authors: Ming-Chao Tsai, Yi-Hao Yen, Kuo-Chin Chang, Chao-Hung Hung, Chien-Hung Chen, Ming-Tsung Lin and Tsung-Hui Hu
    Citation: BMC Cancer 2019 19:1169
    Content type: Research article Published on:

  16. Adult Ewing sarcoma (ES) is a rare disease, the optimal treatment model is unknown. This study aimed to retrospectively analyze treatment-related prognostic factors of nonspinal ES in Chinese adults.

    Authors: Jianjun Zhang, Yujing Huang, Yuanjue Sun, Aina He, Yan Zhou, Haiyan Hu, Yang Yao and Zan Shen
    Citation: BMC Cancer 2019 19:1168
    Content type: Research article Published on:

  17. Circulating tumor cells (CTCs) are associated with breast cancer prognosis. Research is limited regarding the role of circulating cancer stem-like cells (cCSCs) considering the treatment response and survival ...

    Authors: Chun-Hui Lee, Jason Chia-Hsun Hsieh, Tyler Min-Hsien Wu, Ting-Shiuan Yeh, Hung-Ming Wang, Yung-Chan Lin, Jen-Shi Chen, Chia-Lin Lee, Wen-Kuan Huang, Tsung-Min Hung, Tzu-Tsen Yen, Sheng-Chieh Chan, Wen-Chi Chou, Feng-Che Kuan, Ching-Chih Hu and Pei-Hung Chang
    Citation: BMC Cancer 2019 19:1167
    Content type: Research article Published on:

  18. Lung cancer (LC) is one of the leading causes of death worldwide, which highlights the urgent need for better therapies. Peroxisome proliferator-activated nuclear receptor alpha (PPARα), known as a key nuclear...

    Authors: Lujin Wu, Wei Wang, Meiyan Dai, Huihui Li, Chen Chen and Daowen Wang
    Citation: BMC Cancer 2019 19:1166
    Content type: Research article Published on:

  19. Adrenocortical carcinoma (ACC) is a rare malignant endocrine tumour. Due to a high tumour recurrence rate, the post-operative overall survival (OS) and disease-free survival (DFS) of ACCs is limited. Our resea...

    Authors: Jiayu Liang, Zhihong Liu, Xin Wei, Liang Zhou, Yongquan Tang, Chuan Zhou, Kan Wu, Fuxun Zhang, Fan Zhang, Yiping Lu and Yuchun Zhu
    Citation: BMC Cancer 2019 19:1165
    Content type: Research article Published on:

  20. Following publication of the original article [1], the authors reported the following error is the article

    Authors: Shuangmei Ye, Xing Hao, Ting Zhou, Mingfu Wu, Juncheng Wei, Yongjun Wang, Li Zhou, Xuefeng Jiang, Li Ji, Yin Chen, Lanying You, Yiqun Zhang, Gang Xu, Jianfeng Zhou, Ding Ma and Shixuan Wang
    Citation: BMC Cancer 2019 19:1164
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2010 10:611

  21. Patients with metastatic spinal cord compression (MSCC) and favorable survival prognoses can benefit from radiation doses greater than 30Gy in 10 fractions in terms of improved local progression-free survival ...

    Authors: Dirk Rades, Olfred Hansen, Lars Henrik Jensen, Liesa Dziggel, Christian Staackmann, Claudia Doemer, Jon Cacicedo, Antonio J. Conde-Moreno, Barbara Segedin, Raquel Ciervide-Jurio, Carmen Rubio-Rodriguez, Luis A. Perez-Romasanta, Ana Alvarez-Gracia, Kristopher Dennis, Carlos Ferrer-Albiach, Arturo Navarro-Martin…
    Citation: BMC Cancer 2019 19:1163
    Content type: Study protocol Published on:

  22. To compare the efficacy and safety between conventional transarterial chemoembolization (cTACE) and drug-eluting beads TACE (DEB-TACE) in patients with infiltrative hepatocellular carcinoma (iHCC).

    Authors: Zi-shu Zhang, Hui-zhou Li, Cong Ma and Yu-dong Xiao
    Citation: BMC Cancer 2019 19:1162
    Content type: Research article Published on:

  24. Syndecan-1 (SDC-1) is a crucial membrane proteoglycan, which is confirmed to participate in several tumor cell biological processes. However, the biological significance of SDC-1 in colorectal carcinoma is not...

    Authors: Shaojun Wang, Xiaofei Zhang, Guimei Wang, Bin Cao, Hong Yang, Lipeng Jin, Mingjuan Cui and Yongjun Mao
    Citation: BMC Cancer 2019 19:1160
    Content type: Research article Published on:

  25. Breast cancer is one of the most commonly diagnosed cancers in women, with high morbidity and mortality. Tumor metastasis is implicated in most breast cancer deaths; thus, inhibiting metastasis may provide a t...

    Authors: Liyi Huang, Haidan Lin, Qing Chen, Lehua Yu and Dingqun Bai
    Citation: BMC Cancer 2019 19:1159
    Content type: Research article Published on:

  26. Camptothecin (CPT) and its derivatives are currently used as second- or third-line treatment for patients with endocrine-resistant breast cancer (BC). These drugs convert nuclear enzyme DNA topoisomerase I (TO...

    Authors: Cinzia Tesauro, Anne Katrine Simonsen, Marie Bech Andersen, Kamilla Wandsoe Petersen, Emil Laust Kristoffersen, Line Algreen, Noriko Yokoyama Hansen, Anne Bech Andersen, Ann Katrine Jakobsen, Magnus Stougaard, Pavel Gromov, Birgitta R. Knudsen and Irina Gromova
    Citation: BMC Cancer 2019 19:1158
    Content type: Research article Published on:

  28. Personalized therapy for bone metastases should consider the patients’ remaining lifespan. Estimation of survival can be facilitated with scoring tools. A new tool was developed, specifically designed to estim...

    Authors: Dirk Rades, Rapha Haus, Steven E. Schild and Stefan Janssen
    Citation: BMC Cancer 2019 19:1156
    Content type: Research article Published on:

  29. Post-surgical staging is the mainstay of prognostic stratification for colorectal cancer (CRC). Here, we compare TNM staging to consensus molecular subtyping (CMS) and assess the value of subtyping in addition...

    Authors: Rachel V. Purcell, Sebastian Schmeier, Yee Chen Lau, John F. Pearson and Francis A. Frizelle
    Citation: BMC Cancer 2019 19:1155
    Content type: Research article Published on:

  30. Pulmonary sclerosing pneumocytoma (PSP) is a rare benign tumor. Although lymph node metastasis has been reported, it is still considered benign. No malignant transformation has been reported. This is the first...

    Authors: Xiao Teng and Xiaodong Teng
    Citation: BMC Cancer 2019 19:1154
    Content type: Case report Published on:

  31. Half of cancer cases occur in patients aged 70 and above. Majority of older patients are eligible for chemotherapy but evidence for treating this population is sparse and severe toxicities affect more than hal...

    Authors: Zara Steinmeyer, Stéphane Gérard, Thomas Filleron, Stéphanie Lozano, Delphine Brechemier, Gabor Abellan Van Kan, Loic Mourey, Laurence Cristol-Dalstein, Laure De Decker, Yves Rolland and Laurent Balardy
    Citation: BMC Cancer 2019 19:1153
    Content type: Study protocol Published on:

  32. Conventional cystoscopy can detect advanced stages of bladder cancer; however, it has limitations to detect bladder cancer at the early stages. Fluorocoxib A, a rhodamine-conjugated analog of indomethacin, is ...

    Authors: Jennifer Bourn, Kusum Rathore, Robert Donnell, Wesley White, Md. Jashim Uddin, Lawrence Marnett and Maria Cekanova
    Citation: BMC Cancer 2019 19:1152
    Content type: Research article Published on:

  33. Chemotherapy-induced peripheral neuropathy (CIPN) is common among cancer patients treated with neurotoxic chemotherapy agents. Better knowledge on symptom clusters of CIPN may help improve symptom management i...

    Authors: Mian Wang, Hui Lin Cheng, Violeta Lopez, Raghav Sundar, Janelle Yorke and Alex Molassiotis
    Citation: BMC Cancer 2019 19:1151
    Content type: Research article Published on:

  34. Myeloid sarcoma (MS), also known as chloroma, is an extramedullary manifestation of malignant primitive myeloid cells. Previously, only small studies investigated clinical and imaging features of MS. The purpo...

    Authors: Hans-Jonas Meyer, Wolfram Pönisch, Stefan Andreas Schmidt, Susanne Wienbeck, Friederike Braulke, Dominik Schramm and Alexey Surov
    Citation: BMC Cancer 2019 19:1150
    Content type: Research article Published on:

  35. Neurolymphomatosis (NL) is a direct process of invasion of peripheral nerves by lymphoma. It occurs in roughly 5% of patients with lymphoma and represents a particularly difficult diagnostic dilemma when it is...

    Authors: Pierre R. Bourque, Marcos Loreto Sampaio, Jodi Warman-Chardon, Sam Samaan and Carlos Torres
    Citation: BMC Cancer 2019 19:1149
    Content type: Case report Published on:

  36. The association between herpes zoster and the risk of lymphoid neoplasms in Asian populations has not yet been established. We performed a longitudinal follow-up study using a nationwide cohort to assess the r...

    Authors: Hyo Geun Choi, James L. Zehnder, Young Kyung Lee, Hyun Lim and Miyoung Kim
    Citation: BMC Cancer 2019 19:1148
    Content type: Research article Published on:

  37. The advent of the immunomodulatory imide drugs (IMiDs) lenalidomide and thalidomide for the treatment of patients with plasma cell myeloma (PCM), has contributed to more than a doubling of the overall survival...

    Authors: Ryan B. Sinit, Dick G. Hwang, Prakash Vishnu, Jess F. Peterson and David M. Aboulafia
    Citation: BMC Cancer 2019 19:1147
    Content type: Case report Published on:

  38. To evaluate the clinicopathological and prognostic significance of the percentage change between maximum standardized uptake value (SUVmax) at 60 min (SUVmax1) and SUVmax at 120 min (SUVmax2) (ΔSUVmax%) using dua...

    Authors: Yoji YAMAGISHI, Tomomi KOIWAI, Tamio YAMASAKI, Takahiro EINAMA, Makiko FUKUMURA, Miyuki HIRATSUKA, Takako KONO, Katsumi HAYASHI, Jiro ISHIDA, Hideki UENO and Hitoshi TSUDA
    Citation: BMC Cancer 2019 19:1146
    Content type: Research article Published on:

  39. Genetic testing for BRCA1/2 genes is widely used as a strategy to reduce incidence and morbidity of hereditary breast and ovarian cancer (HBOC). The purpose of this study is to analyse the demographic and molecul...

    Authors: Ainara Ruiz de Sabando, Edurne Urrutia Lafuente, Fermín García-Amigot, Angel Alonso Sánchez, Lourdes Morales Garofalo, Sira Moreno, Eva Ardanaz and Maria A. Ramos-Arroyo
    Citation: BMC Cancer 2019 19:1145
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:1227

  40. The relationship between lung dose-volume histogram (DVH) parameters and radiation pneumonitis (RP) associated with induction concurrent chemoradiotherapy (CCRT) followed by surgery in patients with non-small ...

    Authors: Kuniaki Katsui, Takeshi Ogata, Kenta Watanabe, Norihisa Katayama, Junichi Soh, Masahiro Kuroda, Katsuyuki Kiura, Yoshinobu Maeda, Shinichi Toyooka and Susumu Kanazawa
    Citation: BMC Cancer 2019 19:1144
    Content type: Research article Published on:

  41. The aim of this study was to analyze biopsychosocial factors affecting how patients cope with cancer and adjuvant treatment and to appraise psychological distress, coping, perceived social support, quality of ...

    Authors: Teresa García-García, Alberto Carmona-Bayonas, Paula Jimenez-Fonseca, Carlos Jara, Carmen Beato, Beatriz Castelo, Montserrat Mangas, Eva Martínez de Castro, Avinash Ramchandani, David Gomez and Caterina Calderón
    Citation: BMC Cancer 2019 19:1143
    Content type: Research article Published on:

  42. Chronic stress is well known to promote tumor progression, however, little is known whether chronic stress-mediated regulation of osteoblasts contributes to the migration and invasion of metastatic cancer cells.

    Authors: Zhibin Huang, Guihuan Li, Zhishuai Zhang, Ruonan Gu, Wenyang Wang, Xiaoju Lai, Zhong-Kai Cui, Fangyin Zeng, Shiyuan Xu and Fan Deng
    Citation: BMC Cancer 2019 19:1142
    Content type: Research article Published on:

  43. The significance of very early chimerism assessment before day + 28, which is considered the moment of engraftment, is still unclear. In this retrospective study, we evaluated the clinical impact of very early...

    Authors: Monika Lejman, Agnieszka Zaucha-Prażmo, Joanna Zawitkowska, Aleksandra Mroczkowska, Dominik Grabowski, Jerzy R. Kowalczyk and Katarzyna Drabko
    Citation: BMC Cancer 2019 19:1141
    Content type: Research article Published on:

  44. Recent studies have found that inflammatory response is involved in the pathogenesis of ovarian cancer. Advanced ovarian cancer is often presented with ascites that is rich in cytokines, inflammatory factors o...

    Authors: Jun Shi, Rongfen Huo, Ningli Li, Haichuan Li, Tianhang Zhai, Huidan Li, Baihua Shen, Jing Ye, Ruojin Fu and Wen Di
    Citation: BMC Cancer 2019 19:1140
    Content type: Research article Published on:

  45. Thyroid nodules are frequently detected by cervical ultrasound examinations. In follow-up studies, malignant as well as benign nodules may exhibit an increase in size.

    Authors: Michael Cordes, Theresa Ida Götz, Karen Horstrup, Torsten Kuwert and Christian Schmidkonz
    Citation: BMC Cancer 2019 19:1139
    Content type: Research article Published on:

  46. Nuclear factor erythroid 2–related factor 2 (Nrf2) is involved in cell proliferation by promotion of metabolic activity. It is also the major regulator of antioxidants and has a pivotal role in tumor cell prol...

    Authors: Yoshiyuki Yamaguchi, Takao Kamai, Satoru Higashi, Satoshi Murakami, Kyoko Arai, Hiromichi Shirataki and Ken-Ichiro Yoshida
    Citation: BMC Cancer 2019 19:1137
    Content type: Research article Published on:

  47. Post-transplant lymphoproliferative disorders (PTLDs) represent a spectrum of heterogenetic lymphoid proliferations. PTLD is a serious complication that affects the long-term survival of kidney transplant pati...

    Authors: Jian-Chao Zhang, Hui-Xia Lan, Hui-Juan Zhao, Yang-Yang Lei, Li Ma, Xiao-Yan Xie, Ming-de Lu and Wei Wang
    Citation: BMC Cancer 2019 19:1135
    Content type: Case report Published on:

  49. Hepatocellular carcinoma (HCC) is the sixth-most common malignancy worldwide. Multiple previous studies have assessed the relationship between TM6SF2 gene polymorphism and the risk of developing HCC, with disc...

    Authors: Shan Tang, Jing Zhang, Ting-Ting Mei, Hai-Qing Guo, Xin-Huan Wei, Wen-Yan Zhang, Ya-Li Liu, Shan Liang, Zuo-Peng Fan, Li-Xia Ma, Wei Lin, Yi-Rong Liu, Li-Xia Qiu and Hai-Bin Yu
    Citation: BMC Cancer 2019 19:1128
    Content type: Research article Published on:

  50. The platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and neutrophil to lymphocyte ratio (NLR) reflect the systematic inflammatory response, with some evidence revealing that they are ass...

    Authors: Hua-Long Zheng, Jun Lu, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Ping Li, Chao-Hui Zheng and Chang-Ming Huang
    Citation: BMC Cancer 2019 19:1127
    Content type: Research article Published on:

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