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  1. High rates of venous thromboembolic events (VTEs), mainly in advanced disease, are reported for patients with cancer of the upper gastrointestinal tract (stomach, pancreas) and for treatment with cisplatin.

    Authors: Martin Fehr, Hanne Hawle, Stefanie Hayoz, Peter Thuss-Patience, Sabina Schacher, Jorge Riera Knorrenschild, Donat Dürr, Wolfram T. Knoefel, Holger Rumpold, Michael Bitzer, Martin Zweifel, Panagiotis Samaras, Ulrich Mey, Marc Küng, Ralph Winterhalder, Wolfgang Eisterer…
    Citation: BMC Cancer 2020 20:166
    Content type: Research article Published on:

  2. Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators (“writer,” ...

    Authors: Nanfang Qu, Sanyu Qin, Xuemei Zhang, Xiaotong Bo, Zhengchun Liu, Chao Tan, Guiqiong Wen and Haixing Jiang
    Citation: BMC Cancer 2020 20:165
    Content type: Research article Published on:

  3. Following publication of the original article [1], the authors reported an error in the authorship list associated with the paper. Georgina McPherson has therefore been added.

    Authors: Naomi Brewer, Karen Bartholomew, Anna Maxwell, Jane Grant, Georgina McPherson, Helen Wihongi, Collette Bromhead, Nina Scott, Sue Crengle, Chris Cunningham, Jeroen Douwes and John D. Potter
    Citation: BMC Cancer 2020 20:163
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2019 19:1198

  6. The prognostic nutritional index (PNI), which is an easily calculated nutritional index, is significantly associated with patient outcomes in various solid malignancies. This study aimed to evaluate the progno...

    Authors: Takaaki Oba, Kazuma Maeno, Daiya Takekoshi, Mayu Ono, Tokiko Ito, Toshiharu Kanai and Ken-ichi Ito
    Citation: BMC Cancer 2020 20:160
    Content type: Research article Published on:

  7. Lung cancer is the major malignant tumour. The present study was conducted to determine the expression level of syntenin in lung cancer tissues and serum from lung cancer patients and to explore its clinical s...

    Authors: Pengyong Luo, Xuli Yang, Shiren Huang, Shu Feng and Zongxing Ou
    Citation: BMC Cancer 2020 20:159
    Content type: Research article Published on:

  8. Cancer-related fatigue (CRF) is one of the most prevalent complications experienced by cancer patients during and after the process of treatment. Despite conducting a lot of studies, there is no approved thera...

    Authors: Ebrahim Salehifar, Saeid Azimi, Ghasem Janbabai, Ehsan Zaboli, Narjes Hendouei, Fatemeh Saghafi and Samaneh Borhani
    Citation: BMC Cancer 2020 20:158
    Content type: Research article Published on:

  9. Rash is one of the most common severe adverse events associated with use of vemurafenib for the treatment of melanoma, either as monotherapy or in combination with cobimetinib. The study aimed to identify pre-...

    Authors: Ashley M. Hopkins, Akash D. Rathod, Andrew Rowland, Ganessan Kichenadasse and Michael J. Sorich
    Citation: BMC Cancer 2020 20:157
    Content type: Research article Published on:

  10. A BRAF V600E mutation is found as driver oncogene in patients with non-small cell lung cancer. Although combined treatment with dabrafenib and trametinib is highly effective, the efficacy of reduced doses of the ...

    Authors: Yuta Adachi, Naohiro Yanagimura, Chiaki Suzuki, Sakiko Ootani, Azusa Tanimoto, Akihiro Nishiyama, Kaname Yamashita, Koushiro Ohtsubo, Shinji Takeuchi and Seiji Yano
    Citation: BMC Cancer 2020 20:156
    Content type: Case report Published on:

  11. Gemcitabine/erlotinib treatment offers limited benefit in unselected patients with pancreatic ductal adenocarcinoma (PDAC). Development of skin rash has been associated with favorable outcomes in patients trea...

    Authors: C. Benedikt Westphalen, Tobias Kukiolka, Benjamin Garlipp, Lars Hahn, Martin Fuchs, Peter Malfertheiner, Marcel Reiser, Fabian Kütting, Volker Heinemann, Andreas Beringer and Dirk T. Waldschmidt
    Citation: BMC Cancer 2020 20:155
    Content type: Research article Published on:

  12. Cancer recurrence is one of the most concerning clinical problems of cholangiocarcinoma (CCA) patients after treatment. However, an identification of predictive factor on Opisthorchis viverrini (OV)-associated CC...

    Authors: Sureerat Padthaisong, Malinee Thanee, Nisana Namwat, Jutarop Phetcharaburanin, Poramate Klanrit, Narong Khuntikeo, Attapol Titapun and Watcharin Loilome
    Citation: BMC Cancer 2020 20:154
    Content type: Research article Published on:

  13. There is a discrepancy about the metastatic rate of internal mammary lymph nodes (IMNs) between clinical and pathologic findings. We aimed to investigate the metastatic rate of IMNs and to provide recommendati...

    Authors: Li Li, Hongyan Zhang, Linwei Wang, Conghua Xie, Yunfeng Zhou and Yahua Zhong
    Citation: BMC Cancer 2020 20:153
    Content type: Research article Published on:

  14. Despite recent advances in diagnosis and treatment, cervical cancer continues to be a significant health problem worldwide. Whereas robot-assisted surgery has advantages over the abdominal approach, and minima...

    Authors: Kyung Jin Eoh, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim and Young Tae Kim
    Citation: BMC Cancer 2020 20:152
    Content type: Research article Published on:

  15. Alteration in gut microbiota has been recently linked with childhood leukemia and the use of chemotherapy. Whether the perturbed microbiota community is restored after disease remission and cessation of cancer...

    Authors: Ling Ling Chua, Reena Rajasuriar, Yvonne Ai Lian Lim, Yin Ling Woo, P’ng Loke and Hany Ariffin
    Citation: BMC Cancer 2020 20:151
    Content type: Research article Published on:

  16. To investigate clinicopathological variables influencing overall survival, overall recurrence, and post-recurrence survival (PRS) in patients who experienced curative-intent surgical resection of stage I non-s...

    Authors: Chengdi Wang, Yuxuan Wu, Jun Shao, Dan Liu and Weimin Li
    Citation: BMC Cancer 2020 20:150
    Content type: Research article Published on:

  17. It remains controversial whether prophylactic No.10 lymph node clearance is necessary for gastric cancer. Thus, the present study aims to investigate the impact of prophylactic No.10 lymph node clearance on th...

    Authors: Gaozan Zheng, Jinqiang Liu, Yinghao Guo, Fei Wang, Shushang Liu, Guanghui Xu, Man Guo, Xiao Lian, Hongwei Zhang and Fan Feng
    Citation: BMC Cancer 2020 20:149
    Content type: Research article Published on:

  18. Lung adenocarcinoma (LAC) is composed of lepidic, papillary, mucinous, micropapillary and solid components in its parenchyma. Complex responses to therapeutics result from intratumoral heterogeneity. However, ...

    Authors: Yiran Cai, Hongbo Wu, Xiaoqin Shi, Yujie Dong, Xiujun Chang, Li Zhang, Lijuan Zhou, Dan Su and Ming Yang
    Citation: BMC Cancer 2020 20:148
    Content type: Research article Published on:

  19. Brain metastases often occur in cancer evolution. They are not only responsible for death but also for disorders affecting the quality of life and the cognitive functions.

    Authors: Paul Lesueur, William Kao, Alexandra Leconte, Julien Geffrelot, Justine Lequesne, Joëlle Lacroix, Pierre-Emmanuel Brachet, Ioana Hrab, Philippe Royer, Bénédicte Clarisse and Dinu Stefan
    Citation: BMC Cancer 2020 20:147
    Content type: Study protocol Published on:

  20. To evaluate and compare the prognostic performance of four nutritional indicators body mass index (BMI), serum albumin (ALB), prognostic nutritional index (PNI) and nutritional risk index (NRI) in oral cancer ...

    Authors: Xiaodan Bao, Fengqiong Liu, Jing Lin, Qing Chen, Lin Chen, Fa Chen, Jing Wang, Yu Qiu, Bin Shi, Lizhen Pan, Lisong Lin and Baochang He
    Citation: BMC Cancer 2020 20:146
    Content type: Research article Published on:

  21. Aberrant JAK/STAT activation has been detected in many types of human cancers. The role of JAK/STAT activation in cancer has been mostly attributed to direct transcriptional regulation of target genes by phosp...

    Authors: Pranabananda Dutta, Lin Zhang, Huijun Zhang, Qin Peng, Phillippe R. Montgrain, Yingxiao Wang, Yuanlin Song, Jinghong Li and Willis X. Li
    Citation: BMC Cancer 2020 20:145
    Content type: Research article Published on:

  22. Information on the optimal salvage regimen for recurrent esophageal cancer is scarce. We aimed to assess the patterns of locoregional failure, and evaluate the therapeutic efficacy of salvage therapy along wit...

    Authors: Wenjie Ni, Jinsong Yang, Wei Deng, Zefen Xiao, Zongmei Zhou, Hongxing Zhang, Dongfu Chen, Qinfu Feng, Jun Liang, Jima Lv, Xiaozhen Wang, Xin Wang, Tao Zhang, Nan Bi, Lei Deng and Wenqing Wang
    Citation: BMC Cancer 2020 20:144
    Content type: Research article Published on:

  23. MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene expression regulation and have been described as key regulators of carcinogenesis. Aberrant miRNA expression has been frequent...

    Authors: Danielle Pessôa-Pereira, Adriane Feijó Evangelista, Rhafaela Lima Causin, René Aloisio da Costa Vieira, Lucas Faria Abrahão-Machado, Iara Viana Vidigal Santana, Vinicius Duval da Silva, Karen Cristina Borba de Souza, Renato José de Oliveira-Silva, Gabriela Carvalho Fernandes, Rui Manuel Reis, Edenir Inêz Palmero and Márcia Maria Chiquitelli Marques
    Citation: BMC Cancer 2020 20:143
    Content type: Research article Published on:

  24. Thoracic epidural analgesia is the standard postoperative pain management strategy in esophageal cancer surgery. However, paravertebral block analgesia may achieve comparable pain control while inducing less s...

    Authors: B. F. Kingma, W. J. Eshuis, E. M. de Groot, M. L. Feenstra, J. P. Ruurda, S. S. Gisbertz, W. ten Hoope, M. Marsman, J. Hermanides, M. W. Hollmann, C. J. Kalkman, M. D. P. Luyer, G. A. P. Nieuwenhuijzen, H. J. Scholten, M. Buise, M. J. van Det…
    Citation: BMC Cancer 2020 20:142
    Content type: Study protocol Published on:

  25. The term triple-negative breast cancer (TNBC) is used to describe breast cancers without expression of estrogen receptor, progesterone receptor or HER2 amplification. To advance targeted treatment options for ...

    Authors: Karel Kalecky, Rebecca Modisette, Samantha Pena, Young-Rae Cho and Joseph Taube
    Citation: BMC Cancer 2020 20:141
    Content type: Research article Published on:

  26. Whether or not double J (DJ) stenting during transurethral resection of a bladder tumour (TURBT) harms patients with regard to possible metachronous upper urinary tract urothelial cancer (UUTUC) development re...

    Authors: Marie C. Hupe, Lukas Dormayer, Tomasz Ozimek, Julian P. Struck, Martin J. P. Hennig, Melanie Klee, Christoph A. J. von Klot, Markus A. Kuczyk, Axel S. Merseburger and Mario W. Kramer
    Citation: BMC Cancer 2020 20:140
    Content type: Research article Published on:

  27. There is inconsistent evidence on the association between physical activity and pancreatic cancer risk and few studies have investigated early life or life-course physical activity. The objective of this study...

    Authors: Jaspreet Sandhu, Vanessa De Rubeis, Michelle Cotterchio, Brendan T. Smith, Lauren E. Griffith, Darren R. Brenner, Ayelet Borgida, Steven Gallinger, Sean Cleary and Laura N. Anderson
    Citation: BMC Cancer 2020 20:139
    Content type: Research article Published on:

  28. To study the kinetic profile and clinicopathological implications of squamous cell carcinoma antigen (SCC-Ag) in cervical cancer patients who underwent surgery by a self-developed SCC-Ag single molecule assay ...

    Authors: Shuang Ye, Xiaohua Sun, Bin Kang, Fei Wu, Zhong Zheng, Libing Xiang, Mylène Lesénéchal, Fabienne Heskia, Ji Liang and Huijuan Yang
    Citation: BMC Cancer 2020 20:138
    Content type: Research article Published on:

  29. In a previous study (Goebel et. al, Cancer Genomics Proteomics 16:229-244, 2019), we identified 33 biomarkers for an early stage (I-II) Non-Small Cell Lung Cancer (NSCLC) test with 90% accuracy, 80.3% sensitiv...

    Authors: Cherylle Goebel, Christopher L. Louden, Robert Mckenna Jr, Osita Onugha, Andrew Wachtel and Thomas Long
    Citation: BMC Cancer 2020 20:137
    Content type: Research article Published on:

  30. The benefit of adjuvant chemotherapy in invasive lobular carcinoma (ILC) is still unclear. The objective of the current study was to elucidate the effectiveness of adjuvant chemotherapy in hormone receptor (HR...

    Authors: Guangfu Hu, Guangxia Hu, Chengjiao Zhang, Xiaoyan Lin, Ming Shan, Yanmin Yu, Yongwei Lu, Ruijie Niu, Hui Ye, Cheng Wang and Cheng Xu
    Citation: BMC Cancer 2020 20:136
    Content type: Research article Published on:

  31. Overweight/obesity are strongly implicated in breast cancer development, and weight gain post-diagnosis is associated with greater morbidity and all-cause mortality. The aim of this study was to describe the p...

    Authors: Carolyn Ee, Adele Elizabeth Cave, Dhevaksha Naidoo, Kellie Bilinski and John Boyages
    Citation: BMC Cancer 2020 20:113
    Content type: Research article Published on:

  32. Immunotherapy represents a promising option for treatment of hepatocellular carcinoma (HCC) in cirrhotic patients but its efficacy is currently inconsistent and unpredictable. Locoregional therapies inducing i...

    Authors: Ligia Craciun, Roland de Wind, Pieter Demetter, Valerio Lucidi, Ali Bohlok, Sébastien Michiels, Fikri Bouazza, Michael Vouche, Ilario Tancredi, Gontran Verset, Soizic Garaud, Céline Naveaux, Maria Gomez Galdon, Karen Willard Gallo, Alain Hendlisz, Ivan Duran Derijckere…
    Citation: BMC Cancer 2020 20:135
    Content type: Research article Published on:

  33. Diffusion weighted magnetic resonance imaging (DW-MRI) holds great potential for monitoring treatment response in cancer patients shortly after initiation of radiotherapy. It is hypothesized that a decrease in...

    Authors: Frederikke Petrine Fliedner, Trine Bjørnbo Engel, Henrik H. El-Ali, Anders Elias Hansen and Andreas Kjaer
    Citation: BMC Cancer 2020 20:134
    Content type: Research article Published on:

  34. The importance of ACF is not fully explained, however, their number may be a good predictor of synchronous and metachronic adenoma or other polyps whose removal reduces the risk of CRC. Due to the epidemiologi...

    Authors: Marek Kowalczyk, Marcin Orłowski, Łukasz Klepacki, Krzysztof Zinkiewicz, Waldemar Kurpiewski, Dorota Kaczerska, Wiesław Pesta, Ewa Zieliński and Piotr Siermontowski
    Citation: BMC Cancer 2020 20:133
    Content type: Research article Published on:

  35. Microvascular invasion (MVI) is an independent risk factor for poor prognosis in hepatocellular carcinoma (HCC). However, there is still a lack of preoperative markers to predict MVI in HCC. This study intends...

    Authors: Hongxing Zhang, Yu Zhou, Yicheng Li, Wanying Qin, Yunhua Zi, Yulan Liu, Xiaoying Qiu, Hongyuan Xu, Weijia Liao and Zhaoquan Huang
    Citation: BMC Cancer 2020 20:132
    Content type: Research article Published on:

  36. Colorectal cancer (CRC) is the third most prevalent cancer in China but few large-scale studies were conducted to understand CRC patients. The current study is aimed to gain a real-world perspectives of CRC pa...

    Authors: Ruihua Xu, Wei Wang, Bo Zhu, Xiaoyan Lin, Dong Ma, Lingjun Zhu, Qingchuan Zhao, Yongzhan Nie, Xiaohong Cai, Qi Li, Weijia Fang, Hongyan Li, Ning Wang, Yun Chen, Cike Peng, Honghao Fang…
    Citation: BMC Cancer 2020 20:131
    Content type: Research article Published on:

  37. Preoperative chemoradiotherapy (CRT) followed by surgery is the most common approach for patients with resectable esophageal cancer. Nevertheless, considerable numbers of esophageal-cancer patients undergo sur...

    Authors: Wenjie Ni, Shufei Yu, Wencheng Zhang, Zefen Xiao, Zongmei Zhou, Dongfu Chen, Qinfu Feng, Jun Liang, Jima Lv, Shugeng Gao, Yousheng Mao, Qi Xue, Kelin Sun, Xiangyang Liu, Dekang Fang, Jian Li…
    Citation: BMC Cancer 2020 20:130
    Content type: Study protocol Published on:

  38. Colorectal cancer (CRC) is a heterogeneous disease with a complex biology and a wide number of altered genes such as BRAF, KRAS and PIK3CA. Advances with new-targeted therapies have been achieved and available...

    Authors: Evelina Miele, Luana Abballe, Gian Paolo Spinelli, Zein Mersini Besharat, Giuseppina Catanzaro, Martina Chiacchiarini, Alessandra Vacca, Agnese Po, Carlo Capalbo and Elisabetta Ferretti
    Citation: BMC Cancer 2020 20:129
    Content type: Research article Published on:

  39. Following publication of the original article [1], the authors reported that the family name of the author, Ludovica Baldari, was misspelled.

    Authors: Igor Monsellato, Filippo Alongi, Elisa Bertocchi, Stefania Gori, Giacomo Ruffo, Elisa Cassinotti, Ludovica Baldari, Luigi Boni, Graziano Pernazza, Fabio Pulighe, Carlo De Nisco, Roberto Perinotti, Emilio Morpurgo, Tania Contardo, Enzo Mammano, Ugo Elmore…
    Citation: BMC Cancer 2020 20:128
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2019 19:1215

  40. Tumor microenvironment (TME) including the immune checkpoint system impacts prognosis in some types of malignancy. The aim of our study was to investigate the precise prognostic significance of the TME profile...

    Authors: Shuang Zhang, Takeo Minaguchi, Chenyang Xu, Nan Qi, Hiroya Itagaki, Ayumi Shikama, Nobutaka Tasaka, Azusa Akiyama, Manabu Sakurai, Hiroyuki Ochi and Toyomi Satoh
    Citation: BMC Cancer 2020 20:127
    Content type: Research article Published on:

  41. The loss of a single copy of adenomatous polyposis coli (Apc) in leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1)-expressing colonic progenitor cells induces rapid growth of adenomas in mice with hi...

    Authors: Jessica L. Preston and Nicholas Stiffler
    Citation: BMC Cancer 2020 20:126
    Content type: Research article Published on:

  42. Patients with human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPC) have substantially better treatment response and overall survival (OS) than patients with HPV-negative disease. Tr...

    Authors: Anthony C. Nichols, Pencilla Lang, Eitan Prisman, Eric Berthelet, Eric Tran, Sarah Hamilton, Jonn Wu, Kevin Fung, John R. de Almeida, Andrew Bayley, David P. Goldstein, Antoine Eskander, Zain Husain, Houda Bahig, Apostolos Christopoulous, Michael Hier…
    Citation: BMC Cancer 2020 20:125
    Content type: Study protocol Published on:

  43. Colorectal cancer (CRC) is the second leading cancer killer in the US today and patients with metastatic disease have only a 14% 5-year survival. One of the most impactful recent advances in cancer therapy, im...

    Authors: Yuanyuan Shen, Yue Guan, Justin J. Hummel, Chi-Ren Shyu and Jonathan B. Mitchem
    Citation: BMC Cancer 2020 20:124
    Content type: Research article Published on:

  44. Melanoma can be lethal if not detected early and treated. Early detection can be facilitated via skin self-examination (SSE) and as such, SSE is part of melanoma follow-up care for individuals with a prior his...

    Authors: Adina Coroiu, Chelsea Moran, Catherine Bergeron, Martin Drapeau, Beatrice Wang, Abbas Kezouh, Jochen Ernst, Gerald Batist and Annett Körner
    Citation: BMC Cancer 2020 20:123
    Content type: Research article Published on:

  45. Currently, complete surgical resection represents the only potentially curative treatment option for Biliary Tract Cancer (BTC) including Gallbladder Cancer (GBC). Even after curative resection, 5-year OS is o...

    Authors: Thorsten O. Goetze, Wolf O. Bechstein, Ulli Simone Bankstahl, Tobias Keck, Alfred Königsrainer, Sven A. Lang, Claudia Pauligk, Pompiliu Piso, Arndt Vogel and Salah-Eddin Al-Batran
    Citation: BMC Cancer 2020 20:122
    Content type: Study protocol Published on:

  47. The interaction of programmed death-1 protein (PD-1) and programmed death-1 ligand (PD-L1) produces immunosuppressive activity, protecting tumor cells from anti-tumor immunity and possibly releasing soluble PD...

    Authors: Inju Cho, Hansang Lee, Sang Eun Yoon, Kyung Ju Ryu, Young Hyeh Ko, Won Seog Kim and Seok Jin Kim
    Citation: BMC Cancer 2020 20:120
    Content type: Research article Published on:

  48. Ductal carcinoma in situ is a non-obligate precursor of invasive breast carcinoma and presents a potential risk of over or undertreatment. Finding molecular biomarkers of disease progression could allow for mo...

    Authors: Raquel Spinassé Dettogni, Elaine Stur, Ana Carolina Laus, René Aloísio da Costa Vieira, Márcia Maria Chiquitelli Marques, Iara Viana Vidigal Santana, José Zago Pulido, Laura Fregonassi Ribeiro, Narelle de Jesus Parmanhani, Lidiane Pignaton Agostini, Raquel Silva dos Reis, Eldamária de Vargas Wolfgramm dos Santos, Lyvia Neves Rebello Alves, Fernanda Mariano Garcia, Jéssica Aflávio Santos, Diego do Prado Ventorim…
    Citation: BMC Cancer 2020 20:119
    Content type: Research article Published on:

  49. Although shear wave elastography (SWE) is reported to be useful in detecting malignant thyroid nodules, it shows a wide range of cut-off values of elasticity index (EI) in detecting malignant nodules. The caus...

    Authors: Myung Hi Yoo, Hye Jeong Kim, In Ho Choi, Suyeon Park, Sang Jin Kim, Hyeong Kyu Park, Dong Won Byun and Kyoil Suh
    Citation: BMC Cancer 2020 20:118
    Content type: Research article Published on:

  50. Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-associated deaths and a majority of its histological type is manifested as serous ovarian cancer (SOC). In this study, we investigat...

    Authors: Yijing He, Ting Li, Jue Liu, Qiong Ou and Junlin Zhou
    Citation: BMC Cancer 2020 20:116
    Content type: Research article Published on:

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