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  1. The clonoSEQ® Assay (Adaptive Biotechnologies Corporation, Seattle, USA) identifies and tracks unique disease-associated immunoglobulin (Ig) sequences by next-generation sequencing of IgH, IgK, and IgL rearran...

    Authors: Travers Ching, Megan E. Duncan, Tera Newman-Eerkes, Mollie M. E. McWhorter, Jeffrey M. Tracy, Michelle S. Steen, Ryan P. Brown, Srivatsa Venkatasubbarao, Nicholas K. Akers, Marissa Vignali, Martin E. Moorhead, Drew Watson, Ryan O. Emerson, Tobias P. Mann, B. Melina Cimler, Pamela L. Swatkowski…
    Citation: BMC Cancer 2020 20:612
    Content type: Research article Published on:

  2. To explore the clinical value of texture analysis of MR images (multiphase Gd-EOB-DTPA-enhanced MRI and T2 weighted imaging (T2WI) to identify the differentiated degree of hepatocellular carcinoma (HCC).

    Authors: Mengmeng Feng, Mengchao Zhang, Yuanqing Liu, Nan Jiang, Qian Meng, Jia Wang, Ziyun Yao, Wenjuan Gan and Hui Dai
    Citation: BMC Cancer 2020 20:611
    Content type: Research article Published on:

  3. Feasibility testing of a simultaneous sparing approach of hippocampus, hypothalamus and pituitary gland in patients undergoing whole-brain radiotherapy (WBRT) with and without a concomitant boost to metastatic...

    Authors: P. Mehta, S. Janssen, F. B. Fahlbusch, S. M. Schmid, J. Gebauer, F. Cremers, C. Ziemann, M. Tartz and D. Rades
    Citation: BMC Cancer 2020 20:610
    Content type: Research article Published on:

  4. Considering that the knowledge of adenocarcinoma in villous adenoma of the colorectum is limited to several case reports, we designed a study to investigate independent prognostic factors and developed nomogra...

    Authors: Chao-Tao Tang, Ling Zeng, Jing Yang, Chunyan Zeng and Youxiang Chen
    Citation: BMC Cancer 2020 20:608
    Content type: Research article Published on:

  5. Small hepatocellular carcinoma (sHCC) is a special subtype of HCC with the maximum tumor diameter ≤ 3 cm and excellent long-term outcomes. Surgical resection or radiofrequency ablation provides the greatest ch...

    Authors: Yi-hong Ling, Jie-wei Chen, Shi-hong Wen, Chao-yun Huang, Peng Li, Liang-he Lu, Jie Mei, Shao-hua Li, Wei Wei, Mu-yan Cai and Rong-ping Guo
    Citation: BMC Cancer 2020 20:607
    Content type: Research article Published on:

  6. Cancer testis (CT) antigens are promising targets for cancer immunotherapies such as cancer vaccines and genetically modified adoptive T cell therapy. In this study, we evaluated the expression of three CT ant...

    Authors: Mikiya Ishihara, Shinichi Kageyama, Yoshihiro Miyahara, Takeshi Ishikawa, Shugo Ueda, Norihito Soga, Hiroaki Naota, Katsumi Mukai, Naozumi Harada, Hiroaki Ikeda and Hiroshi Shiku
    Citation: BMC Cancer 2020 20:606
    Content type: Research article Published on:

  8. Little is known about the prevalence and incidence in low and middle-income countries (LMICs) of secondary lymphedema due to cancer. The purpose of the study is to estimate the prevalence and incidence in LMIC...

    Authors: Eric Torgbenu, Tim Luckett, Mark A. Buhagiar, Sungwon Chang and Jane L. Phillips
    Citation: BMC Cancer 2020 20:604
    Content type: Research article Published on:

  9. Modulated electro-hyperthermia (mEHT) is a form of hyperthermia used in cancer treatment. mEHT has demonstrated the ability to activate host immunity by inducing the release of heat shock proteins, triggering ...

    Authors: I-Ming Kuo, Jih-Jong Lee, Yu-Shan Wang, Hsin-Chien Chiang, Cheng-Chung Huang, Pei-Jong Hsieh, Winston Han, Chiao-Hsu Ke, Albert T. C. Liao and Chen-Si Lin
    Citation: BMC Cancer 2020 20:603
    Content type: Research article Published on:

  10. Esophageal squamous cell carcinoma (ESCC) is a common malignant carcinoma of digestive system with high mortality. RAB, member RAS oncogene family like 6 (RABL6), a member of the RAS subfamily, has been reported ...

    Authors: Yanfen Feng, Shumei Yan, Yuhua Huang, Qitao Huang, Fang Wang and Yiyan Lei
    Citation: BMC Cancer 2020 20:602
    Content type: Research article Published on:

  11. Since body mass index (BMI) is a convincing risk factor for breast cancer, it is speculated to be associated with lymph node metastasis. However, epidemiological studies are inconclusive. Therefore, this study...

    Authors: Junyi Wang, Yaning Cai, Fangfang Yu, Zhiguang Ping and Li Liu
    Citation: BMC Cancer 2020 20:601
    Content type: Research article Published on:

  12. Colorectal cancer (CRC) is a multifactorial disease resulting from both genetic predisposition and environmental factors including the gut microbiota (GM), but deciphering the influence of genetic variants, en...

    Authors: Jacob E. Moskowitz, Anthony G. Doran, Zhentian Lei, Susheel B. Busi, Marcia L. Hart, Craig L. Franklin, Lloyd W. Sumner, Thomas M. Keane and James M. Amos-Landgraf
    Citation: BMC Cancer 2020 20:600
    Content type: Research article Published on:

  13. Cost-effectiveness is a pivotal consideration for clinical decision making of high-tech cancer treatment in developing countries. Intensity-modulated proton radiation therapy (IMPT, the advanced form of proton...

    Authors: Guo Li, Bo Qiu, Yi-Xiang Huang, Jerome Doyen, Pierre-Yves Bondiau, Karen Benezery, Yun-Fei Xia and Chao-Nan Qian
    Citation: BMC Cancer 2020 20:599
    Content type: Research article Published on:

  14. Lymph node metastasis is more likely in early-stage breast cancer with lower tumor-infiltrating lymphocyte (TIL) density. Therefore, we investigated the correlation between TILs and lymph node metastasis in cT...

    Authors: Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Rika Kouhashi, Akimichi Yabumoto, Tamami Morisaki, Masatsune Shibutani, Tsutomu Takashima, Hisakazu Fujita, Kosei Hirakawa and Masaichi Ohira
    Citation: BMC Cancer 2020 20:598
    Content type: Research article Published on:

  15. A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a ...

    Authors: Pierre-Antoine Bissey, Mona Teng, Jacqueline H. Law, Wei Shi, Jeff P. Bruce, Valentin Petit, Sai W. Tsao, Kenneth W. Yip and Fei-Fei Liu
    Citation: BMC Cancer 2020 20:597
    Content type: Research article Published on:

  16. Soft-tissue metastasis (STM) is a relatively rare, but not exceptional, manifestation of lung cancer. The purpose of this study was to evaluate the imaging features of STM from lung cancer using fluorine-18 fl...

    Authors: Tingting Xu, Xinyi Zhang, Shumao Zhang, Chunfeng Liu, Wenhui Fu, Chengrun Zeng and Yue Chen
    Citation: BMC Cancer 2020 20:596
    Content type: Research article Published on:

  17. Unlike other breast cancer subtypes that may be treated with a variety of hormonal or targeted therapies, there is a need to identify new, effective targets for triple-negative breast cancer (TNBC). It has rec...

    Authors: Gina Sizemore, Sarah McLaughlin, Mackenzie Newman, Kathleen Brundage, Amanda Ammer, Karen Martin, Elena Pugacheva, James Coad, Malcolm D. Mattes and Han-Gang Yu
    Citation: BMC Cancer 2020 20:595
    Content type: Research article Published on:

  18. Patients with cancer have an increased risk of malnutrition which is associated with poor outcome. The Mini Nutritional Assessment (MNA®) is often used in older patients with cancer but its relation to outcome...

    Authors: G. Torbahn, T. Strauss, C. C. Sieber, E. Kiesswetter and D. Volkert
    Citation: BMC Cancer 2020 20:594
    Content type: Research article Published on:

  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Qi Wang, Zixiang Wu, Tianwei Zhan, Shuai Fang, Sai Zhang, Gang Shen and Ming Wu
    Citation: BMC Cancer 2020 20:593
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2019 19:500

  20. Metastatic colorectal cancer (CRC) continues to be a major health problem, and current treatments are primarily for disease control and palliation of symptoms. In this study, we developed a precision medicine ...

    Authors: Erdem Altunel, Roham S. Roghani, Kai-Yuan Chen, So Young Kim, Shannon McCall, Kathryn E. Ware, Xiling Shen, Jason A. Somarelli and David S. Hsu
    Citation: BMC Cancer 2020 20:592
    Content type: Research article Published on:

  21. The prognosis of patients with progressive or recurrent high-grade gliomas (HGGs) after surgery remains poor. Iodine-125 brachytherapy is emerging as a salvage method for the treatment of gliomas. This study a...

    Authors: Congxiao Wang, Shifeng Liu, Lijing Peng, Kaixian Zhang, Wei Li, Hao Zhang, Ying Luan, Peishun Li and Xiaokun Hu
    Citation: BMC Cancer 2020 20:591
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:736

  22. Ex vivo drug screening refers to the out-of-body assessment of drug efficacy in patient derived vital tumor cells. The purpose of these methods is to enable functional testing of patient specific efficacy of a...

    Authors: Rami Mäkelä, Antti Arjonen, Ville Härmä, Nina Rintanen, Lauri Paasonen, Tobias Paprotka, Kerstin Rönsch, Teijo Kuopio, Juha Kononen and Juha K. Rantala
    Citation: BMC Cancer 2020 20:590
    Content type: Research article Published on:

  23. We examined the association between obesity and prostate cancer based on both body mass index (BMI) and waist circumference (WC) using the National Health Insurance System (NHIS) database for the entire male p...

    Authors: Jin Bong Choi, Jun-Pyo Myong, Yunhee Lee, Inah Kim, Jung Ho Kim, Sung-Hoo Hong and U-Syn Ha
    Citation: BMC Cancer 2020 20:589
    Content type: Research article Published on:

  24. Prostate Cancer (PCa) is the second most common cancer in men where advancements have been made for early detection using imaging techniques, however these are limited by lesion size. Immune surveillance has e...

    Authors: Ali Mehdi, David Cheishvili, Ani Arakelian, Tarek A. Bismar, Moshe Szyf and Shafaat A. Rabbani
    Citation: BMC Cancer 2020 20:588
    Content type: Research article Published on:

  25. Gastric cancer is one of the deadliest cancer entities worldwide. While surgery is the only curative treatment option in early tumors, for locally advanced and metastatic patients further therapeutic targets a...

    Authors: Jan Rehkaemper, Michael Korenkov, Alexander Quaas, Josef Rueschoff, Aylin Pamuk, Thomas Zander, Axel M. Hillmer, Reinhard Buettner, Arnulf Heinrich Hoelscher, Christiane Josephine Bruns, Heike Loeser, Hakan Alakus and Birgid Schoemig-Markiefka
    Citation: BMC Cancer 2020 20:587
    Content type: Research article Published on:

  26. HOXA family genes were crucial transcription factors involving cell proliferation and apoptosis. While few studies have focused on HOXA10 in AML. We aimed to investigate the prognostic significance of HOXA10.

    Authors: Chao Guo, Qian-qian Ju, Chun-xia Zhang, Ming Gong, Zhen-ling Li and Ya-yue Gao
    Citation: BMC Cancer 2020 20:586
    Content type: Research article Published on:

  28. Previous studies have shown that branched-chain amino acid transferase 1 (BCAT1) is associated with tumour progression in triple-negative breast cancer (TNBC). Furthermore, CD133 has emerged as a novel cancer ...

    Authors: Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yan Lin, Liangrui Zhou and Qiang Sun
    Citation: BMC Cancer 2020 20:584
    Content type: Research article Published on:

  29. P53 pathway inactivation plays an important role in the process of breast cancer tumorigenesis. Post-translational protein modification abnormalities have been confirmed to be an important mechanism underlying...

    Authors: Qian Pu, Yan-rong Lv, Ke Dong, Wen-wen Geng and Hai-dong Gao
    Citation: BMC Cancer 2020 20:583
    Content type: Research article Published on:

  30. As a natural alkaloid product isolated from Sophora alopecuroides. L, Sophoridine reshapes gastric cancer immune microenvironment via inhibiting chemotaxis and M2 polarization of tumor-associated macrophages (TAM...

    Authors: Zhiyang Peng, Qing Guan, Jianfei Luo, Wenhong Deng, Jiasheng Liu, Ruicheng Yan and Weixing Wang
    Citation: BMC Cancer 2020 20:582
    Content type: Research article Published on:

  31. Esophageal carcinoma (EC) is the seventh-most prevalent tumor in the world, which is still one of the primary causes of tumor-related death. Identifying noteworthy biomarkers for EC is particularly significant...

    Authors: Yiding Li, Guiling Wu, Wanli Yang, Xiaoqian Wang, Lili Duan, Liaoran Niu, Yujie Zhang, Jinqiang Liu, Liu Hong and Daiming Fan
    Citation: BMC Cancer 2020 20:581
    Content type: Research article Published on:

  32. Non-small cell lung cancer (NSCLC) remains a huge health burden for human health and life worldwide. Our study here was to illuminate the relevance of microRNA-130a-5p (miR-130a-5p) on growth and epithelial me...

    Authors: Fang Ma, Yangchun Xie, Yiyu Lei, Zengshuyu Kuang and Xianling Liu
    Citation: BMC Cancer 2020 20:580
    Content type: Research article Published on:

  33. To explore the diagnostic value of radiomics features of preoperative computed tomography (CT) for triple negative breast cancer (TNBC) for better treatment of patients with breast cancer.

    Authors: Qingliang Feng, Qiang Hu, Yan Liu, Tao Yang and Ziyi Yin
    Citation: BMC Cancer 2020 20:579
    Content type: Research article Published on:

  34. This pilot trial aimed to investigate whether modified short-term fasting (mSTF) reduces the incidence of chemotherapy-induced toxicities and whether an initial ketogenic diet (KD) as fasting supportive diet r...

    Authors: Stefanie Zorn, Janine Ehret, Rebecca Schäuble, Beate Rautenberg, Gabriele Ihorst, Hartmut Bertz, Paul Urbain and Anna Raynor
    Citation: BMC Cancer 2020 20:578
    Content type: Research article Published on:

  35. Qualitative research on cancer patients’ survivor-identity and lived experiences in low- and middle-income countries is scarce. Our study aimed at exploring the concept and experience of survivorship for Mexic...

    Authors: Felicia Marie Knaul, Svetlana V. Doubova, María Cecilia Gonzalez Robledo, Alessandra Durstine, Gabriela Sophia Pages, Felicia Casanova and Hector Arreola-Ornelas
    Citation: BMC Cancer 2020 20:577
    Content type: Research article Published on:

  36. Omega-3 polyunsaturated fatty acids (PUFAs) were proposed to have potential effects against inflammation and cancer. However, results from epidemiology studies remain inconsistent. We aimed to explore the asso...

    Authors: Peiqin Li, Boer Shan, Keyu Jia, Fan Hu, Ying Xiao, Jusheng Zheng, Yu-Tang Gao, Huaying Wang and Ying Gao
    Citation: BMC Cancer 2020 20:576
    Content type: Research article Published on:

  38. In patients undergoing major liver resection, portal vein embolization (PVE) has been widely used to induce hypertrophy of the non-embolized liver in order to prevent post-hepatectomy liver failure. PVE is a s...

    Authors: Emmanuel Deshayes, Lauranne Piron, Antoine Bouvier, Bruno Lapuyade, Emilie Lermite, Laurent Vervueren, Christophe Laurent, Jean-Baptiste Pinaquy, Patrick Chevallier, Anthony Dohan, Agnès Rode, Christian Sengel, Chloé Guillot, François Quenet and Boris Guiu
    Citation: BMC Cancer 2020 20:574
    Content type: Study protocol Published on:

  39. This study aims to determine the real incidence of pericolic lymph nodes metastasis beyond 10 cm proximal to the tumor (pPCN) and its prognostic significance in rectal cancer patients.

    Authors: Xuyang Yang, Erliang Zheng, Lina Ye, Chaoyang Gu, Tao Hu, Dan Jiang, Du He, Bing Wu, Qinbing Wu, Tinghan Yang, Mingtian Wei, Wenjian Meng, Xiangbing Deng, Ziqiang Wang and Zongguang Zhou
    Citation: BMC Cancer 2020 20:573
    Content type: Research article Published on:

  40. Despite recent advances in cancer immunotherapy, the efficacy of these therapies for the treatment of human prostate cancer patients is low due to the complex immune evasion mechanisms (IEMs) of prostate cance...

    Authors: Mayassa J. Bou-Dargham, Linlin Sha, Qing-Xiang Amy Sang and Jinfeng Zhang
    Citation: BMC Cancer 2020 20:572
    Content type: Research article Published on:

  41. The resistance of lung cancer to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) is one of the unconquered frontiers in chemotherapy. Mitogen-inducible gene 6 (Mig-6) is known to inhibit ...

    Authors: Da Hyun Kang, Sung Soo Jung, Min-Kyung Yeo, Da Hye Lee, Geon Yoo, Sang Yeon Cho, In-Jae Oh, Ju-Ock Kim, Hee Sun Park, Chaeuk Chung and Jeong Eun Lee
    Citation: BMC Cancer 2020 20:571
    Content type: Research article Published on:

  42. In principle, risk-stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) should produce a better balance of benefits and harms. The main benefit is the offer of NICE-approved more fre...

    Authors: David P. French, Susan Astley, Adam R. Brentnall, Jack Cuzick, Richard Dobrashian, Stephen W. Duffy, Louise S. Gorman, Elaine F. Harkness, Fiona Harrison, Michelle Harvie, Anthony Howell, Andrew Jerrison, Matthew Machin, Anthony J. Maxwell, Lorna McWilliams, Katherine Payne…
    Citation: BMC Cancer 2020 20:570
    Content type: Study protocol Published on:

  43. KRAS mutations are prevalent in 40–45% of patients with colorectal cancer (CRC) and targeting this gene has remained elusive. Viruses are well known immune sensitizing agents. The therapeutic efficacy of oncolyti...

    Authors: Ruwan Parakrama, Elisha Fogel, Carol Chandy, Titto Augustine, Matt Coffey, Lydia Tesfa, Sanjay Goel and Radhashree Maitra
    Citation: BMC Cancer 2020 20:569
    Content type: Research article Published on:

  44. Prognostic biomarkers provide essential information about a patient’s overall outcome. However, existing biomarkers are limited in terms of either sample collection, such as requiring tissue specimens, or the ...

    Authors: Takumi Hasegawa, Tomoya Iga, Daisuke Takeda, Rika Amano, Izumi Saito, Yasumasa Kakei, Junya Kusumoto, Akira Kimoto, Akiko Sakakibara and Masaya Akashi
    Citation: BMC Cancer 2020 20:568
    Content type: Research article Published on:

  45. Skin cancer is the most common cancer worldwide and commonly classified into malignant melanoma (MM) and Nonmelanoma skin cancers (NMSCs), which mainly include basal cell carcinoma (BCC) and squamous cell carc...

    Authors: Mohammad Ali Zolfaghari, Abbas Karimi, Elham Kalantari, Alireza Korourian, Alireza Ghanadan, Kambiz Kamyab, Nafiseh Esmaili, Amir Nader Emami Razavi and Zahra Madjd
    Citation: BMC Cancer 2020 20:567
    Content type: Research article Published on:

  46. Only 10–30% of oesophageal and rectal adenocarcinoma patients treated with neoadjuvant chemoradiotherapy have a complete pathological response. Inflammatory and angiogenic mediators in the tumour microenvironm...

    Authors: Maria E. Morrissey, Róisín Byrne, Celina Nulty, Niamh H. McCabe, Niamh Lynam-Lennon, Clare T. Butler, Susan Kennedy, Dermot O’Toole, John Larkin, Paul McCormick, Brian Mehigan, Mary-Clare Cathcart, Joanne Lysaght, John V. Reynolds, Elizabeth J. Ryan, Margaret R. Dunne…
    Citation: BMC Cancer 2020 20:566
    Content type: Research article Published on:

  47. It may be impossible to perform cancer surgery with free margins in the presence of an unresectable structure. Local drug treatment after surgery has been proposed to increase the rate of tumor control.

    Authors: Iman Al Dybiat, Alibi Baitukha, Cynthia Pimpie, Rachid Kaci, Marc Pocard, Farzaneh Arefi Khonsari and Massoud Mirshahi
    Citation: BMC Cancer 2020 20:565
    Content type: Research article Published on:

  48. Differentiation of suprasellar meningiomas (SSMs) from non-functioning pituitary macroadenomas (NFPMAs) is useful for clinical management. We investigated the utility of 13N-ammonia combined with 18F-FDG positron...

    Authors: Lei Ding, Fangling Zhang, Qiao He, Zhoulei Li, Xinchong Shi, Ruocheng Li and Xiangsong Zhang
    Citation: BMC Cancer 2020 20:564
    Content type: Research article Published on:

  49. Cervical cancer is the fourth most common cancer among women worldwide. Sub- Saharan Africa has a high incidence, prevalence and mortality due to shortage and underutilization of screening facilities. This stu...

    Authors: Friederike Ruddies, Muluken Gizaw, Brhanu Teka, Sarah Thies, Andreas Wienke, Andreas M. Kaufmann, Tamrat Abebe, Adamu Addissie and Eva Johanna Kantelhardt
    Citation: BMC Cancer 2020 20:563
    Content type: Research article Published on:

  50. A prognostic model combining biomarkers of metaphase-anaphase transition of the cell cycle was developed for invasive breast cancer. The prognostic value and clinical applicability of the model was evaluated i...

    Authors: Heli Repo, Eliisa Löyttyniemi, Samu Kurki, Lila Kallio, Teijo Kuopio, Kati Talvinen and Pauliina Kronqvist
    Citation: BMC Cancer 2020 20:558
    Content type: Research article Published on:

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