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  1. The likelihood of a tumor recurrence in patients with T3-4N0–1 non-small cell lung cancer following multimodality treatment remains substantial, mainly due distant metastases. As pathological complete response...

    Authors: Chris Dickhoff, Suresh Senan, Famke L. Schneiders, Joris Veltman, Sayed Hashemi, Johannes M. A. Daniels, Marieke Fransen, David J. Heineman, Teodora Radonic, Peter M. van de Ven, Imke H. Bartelink, Lilian J. Meijboom, Juan J. Garcia-Vallejo, Daniela E. Oprea-Lager, Tanja D. de Gruijl and Idris Bahce
    Citation: BMC Cancer 2020 20:764
    Content type: Study protocol Published on:

  2. Despite the possible traumatic significance of cancer and of the incidence, prevalence, and survival of young women with breast cancer, these patients are underrepresented in multidimensional research. In the ...

    Authors: Barbara Muzzatti, Francesca Bomben, Cristiana Flaiban, Marika Piccinin and Maria Antonietta Annunziata
    Citation: BMC Cancer 2020 20:758
    Content type: Research article Published on:

  3. Prostate cancer patients are known to suffer from poor sexual and urinary long-term side-effects following treatment, potentially impacting quality of life. The purpose of our study was to compare health-relat...

    Authors: Nadine Houédé, Xavier Rébillard, Sophie Bouvet, Sarah Kabani, Pascale Fabbro-Peray, Brigitte Trétarre and Florence Ménégaux
    Citation: BMC Cancer 2020 20:757
    Content type: Research article Published on:

  5. Medulloblastoma is extremely rare in adults. The role of chemotherapy for average-risk adult patients remains controversial. Surgery and radiotherapy provide a significant disease control and a good prognosis,...

    Authors: E. Franceschi, S. Minichillo, A. Mura, A. Tosoni, M. Mascarin, C. Tomasello, S. Bartolini and A. A. Brandes
    Citation: BMC Cancer 2020 20:755
    Content type: Research article Published on:

  6. Living donor liver transplantation (LDLT) is an acceptable treatment option for hepatocellular carcinoma (HCC). Traditional transplant criteria aim at best utilization of donor organs with low risk of post tra...

    Authors: Abu Bakar Hafeez Bhatti, Ammal Imran Qureshi, Rizmi Tahir, Faisal Saud Dar, Nusrat Yar Khan, Haseeb Haider Zia, Shahzad Riyaz and Atif Rana
    Citation: BMC Cancer 2020 20:754
    Content type: Research article Published on:

  7. Ovarian tissue cryopreservation has a wide range of cancerous indications. Avoiding relapse becomes a specific concern that clinicians frequently encounter. The data about the comparative viability of cancer c...

    Authors: Xinxin Du, Plamen Todorov, Evgenia Isachenko, Gohar Rahimi, Peter Mallmann, Yuanguang Meng and Vladimir Isachenko
    Citation: BMC Cancer 2020 20:753
    Content type: Research article Published on:

  8. The present study was conducted to determine the trend and projection of premature mortality from gastrointestinal cancers (GI cancers) at national and subnational levels in Iran.

    Authors: Fatemeh Khosravi Shadmani, Farshad Farzadfar, Moein Yoosefi, Kamyar Mansori, Reza Khosravi Shadman and Aliakbar Haghdoost
    Citation: BMC Cancer 2020 20:752
    Content type: Research article Published on:

  9. The survival rates of women with breast cancer have improved significantly over the last four decades due to advances in breast cancer early diagnosis and therapy. However, breast cancer survivors have an incr...

    Authors: Zaid H. Maayah, Shingo Takahara, Abrar S. Alam, Mourad Ferdaoussi, Gopinath Sutendra, Ayman O. S. El-Kadi, John R. Mackey, Edith Pituskin, D. Ian Paterson and Jason R. B. Dyck
    Citation: BMC Cancer 2020 20:751
    Content type: Research article Published on:

  10. NLR, PLR, and LMR have been associated with pancreatic ductal adenocarcinoma (PDAC) survival. Prognostic value and optimal cutpoints were evaluated to identify underlying significance in surgical PDAC patients.

    Authors: David T. Pointer Jr., David Roife, Benjamin D. Powers, Gilbert Murimwa, Sameh Elessawy, Zachary J. Thompson, Michael J. Schell, Pamela J. Hodul, Jose M. Pimiento, Jason B. Fleming and Mokenge P. Malafa
    Citation: BMC Cancer 2020 20:750
    Content type: Research article Published on:

  11. Accumulating evidence has revealed the critical role of long non-coding RNAs (lncRNAs) in cellular processes during tumor progression. As documented in cancer-related literatures, LINC00992 expression is assoc...

    Authors: Jianheng Chen, Xiaodong Liu, Kunbin Ke, Jianan Zou, Zhan Gao, Tomonori Habuchi and Xuezhen Yang
    Citation: BMC Cancer 2020 20:749
    Content type: Research article Published on:

  12. Tumors with deficient homologous repair are sensitive to PARP inhibitors such as olaparib which is known to have immunogenic properties. Durvalumab (D) is a human monoclonal antibody (mAb) which inhibits bindi...

    Authors: Jean-David Fumet, Emeric Limagne, Marion Thibaudin, Caroline Truntzer, Aurélie Bertaut, Emilie Rederstorff and Francois Ghiringhelli
    Citation: BMC Cancer 2020 20:748
    Content type: Study protocol Published on:

  13. Hereditary breast and ovarian cancer (HBOC) is an autosomal dominant inherited cancer susceptibility disorder. Both BRCA1 and BRCA2 genes are considered as high penetrance genes of this syndrome. The identificati...

    Authors: Fatima Zahra El Ansari, Farah Jouali, Nabila Marchoudi, Mohcine Mechita Bennani, Naima Nourouti Ghailani, Amina Barakat and Jamal Fekkak
    Citation: BMC Cancer 2020 20:747
    Content type: Research article Published on:

  14. Pregnancy-associated breast cancer (PABC) is defined as breast cancer that is diagnosed during pregnancy and/or the postpartum period. Definitions of the duration of the postpartum period have been controversi...

    Authors: Chunchun Shao, Zhigang Yu, Juan Xiao, Liyuan Liu, Fanzhen Hong, Yuan Zhang and Hongying Jia
    Citation: BMC Cancer 2020 20:746
    Content type: Research article Published on:

  15. Anti-Androgen Receptor (AR) therapy holds promise for a subset of AR expressing triple-negative breast cancer (TNBC) patients. However, current AR assays are suboptimal in detecting the dynamic range of AR exp...

    Authors: Sindhu Govindan, Mallikarjuna Siraganahalli Eswaraiah, Chetana Basavaraj, Manjula Adinarayan, Satish Sankaran and Manjiri Bakre
    Citation: BMC Cancer 2020 20:745
    Content type: Research article Published on:

  16. At the time of surgery, approximately 10–20% of the patients with pancreatic cancer are considered unresectable because of unexpected liver metastasis, peritoneal carcinomatosis or locally advanced disease. Th...

    Authors: G. Litjens, D. M. Rivière, E. J. M. van Geenen, S. A. Radema, L. A. A. Brosens, M. Prokop, C. J. H. M. van Laarhoven and J. J. Hermans
    Citation: BMC Cancer 2020 20:744
    Content type: Study protocol Published on:

  17. The development and rapid uptake of immune checkpoint inhibitors (CPI) has changed the outlook for patients with cancer. However, CPIs have different adverse event (AE) profiles to other systemic therapies, an...

    Authors: Liz Jamieson, Martin D. Forster, Kam Zaki, Sanjena Mithra, Heena Alli, Anne O’Connor, Apini Patel, Ian C. K. Wong and Pinkie Chambers
    Citation: BMC Cancer 2020 20:743
    Content type: Research article Published on:

  18. Several studies have reported the incidence of interstitial pneumonia (IP) among patients with non-Hodgkin lymphoma (NHL) that are undergoing combination chemotherapy plus rituximab; however, the effective pro...

    Authors: Cong Li, Fangxiao Lu, Tao Lei, Haifeng Yu, Xi Chen, Shuailing Peng, Shuiyun Han and Haiyan Yang
    Citation: BMC Cancer 2020 20:742
    Content type: Research article Published on:

  19. The deubiquitinating (DUB) enzyme ubiquitin-specific protease 18 (USP18), also known as UBP43, is an ubiquitin-specific protease linked to several human malignancies. However, USP18’s underlying function in hu...

    Authors: Wenjing Diao, Qisang Guo, Caiying Zhu, Yu Song, Hua Feng, Yuankui Cao, Ming Du and Huifen Chen
    Citation: BMC Cancer 2020 20:741
    Content type: Research article Published on:

  20. Precision oncology pharmacotherapy relies on precise patient-specific alterations that impact drug responses. Due to rapid advances in clinical tumor sequencing, an urgent need exists for a clinical support to...

    Authors: Quan Xu, Jin-Cheng Zhai, Cai-Qin Huo, Yang Li, Xue-Jiao Dong, Dong-Fang Li, Ru-Dan Huang, Chuang Shen, Yu-Jun Chang, Xi-Ling Zeng, Fan-Lin Meng, Fang Yang, Wan-Ling Zhang, Sheng-Nan Zhang, Yi-Ming Zhou and Zhi Zhang
    Citation: BMC Cancer 2020 20:740
    Content type: Software Published on:

  21. Cancer-related fatigue represents one major cause of reduced quality of life in cancer patients and can seriously affect the physical, emotional, and cognitive functioning impeding coping with the disease. Opt...

    Authors: Ben Schöttker, Sabine Kuznia, Dana Clarissa Laetsch, David Czock, Annette Kopp-Schneider, Reiner Caspari and Hermann Brenner
    Citation: BMC Cancer 2020 20:739
    Content type: Study protocol Published on:

  22. Lung cancer is the number one cancer killer worldwide. A major drawback in the lung cancer treatment field is the lack of realistic mouse models that replicate the complexity of human malignancy and immune con...

    Authors: Julian Ramelow, Christopher D. Brooks, Li Gao, Abeer A. Almiman, Terence M. Williams, Miguel A. Villalona-Calero and Wenrui Duan
    Citation: BMC Cancer 2020 20:738
    Content type: Research article Published on:

  23. Disparities in multiple myeloma (MM) prognosis based on sociodemographic factors may exist. We investigated whether education level at diagnosis influenced Chinese MM patient outcomes.

    Authors: Limei Xu, Xiuju Wang, Xueyi Pan, Xiaotao Wang, Qing Wang, Bingyi Wu, Jiahui Cai, Ying Zhao, Lijuan Chen, Wuping Li and Juan Li
    Citation: BMC Cancer 2020 20:737
    Content type: Research article Published on:

  25. Seroma formation is a common complication after breast cancer surgery and can lead to delayed wound healing, infection, patient discomfort and repeated visits to the outpatient clinic. Mastectomy combined with...

    Authors: Lisa de Rooij, Sander M. J. van Kuijk, Els R. M. van Haaren, Alfred Janssen, Yvonne L. J. Vissers, Geerard L. Beets and James van Bastelaar
    Citation: BMC Cancer 2020 20:735
    Content type: Study protocol Published on:

  26. Laryngocarcinoma (LC), in most cases a squamous cell carcinoma, accounts for 1 ~ 5% of the incidence of all tumors. At present, laryngocarcinoma is mainly managed with the integration of surgery and radio- and...

    Authors: Yining Yang, Li Li, Yongzhe Zheng, Qingfeng Liu, Xianfeng Wei, Xinyuan Gong, Wei Wang and Peng Lin
    Citation: BMC Cancer 2020 20:734
    Content type: Study protocol Published on:

  28. Risk stratification and prognosis prediction of acute myeloid leukemia (AML) are largely dependent on pre-treatment information. However, post-treatment data also provides much useful information. In this retr...

    Authors: Yang Wang, Hua Wang, Weida Wang, Wenjian Liu, Nawei Liu, Shuang Liu and Yue Lu
    Citation: BMC Cancer 2020 20:732
    Content type: Research article Published on:

  29. Cancer cells induce the infiltration of various immune cells that are located or distributed in different sites and play multiple roles, which have recently been proposed to predict clinical outcomes. We there...

    Authors: Jie Wang, Shu Tian, Ji Sun, Jiahao Zhang, Lan Lin and Chunyan Hu
    Citation: BMC Cancer 2020 20:731
    Content type: Research article Published on:

  30. Primary surgery is usually the mainstay treatment in early-stage oropharyngeal and oral cavity cancer. Typically, neck surgery is performed. Negative tumor margins are recommended (> 5 mm). If feasible, re-res...

    Authors: Julian Biau, Emilie Thivat, Corinne Millardet, Nicolas Saroul, Nathalie Pham-Dang, Ioana Molnar, Bruno Pereira, Xavier Durando, Jean Bourhis and Michel Lapeyre
    Citation: BMC Cancer 2020 20:730
    Content type: Study protocol Published on:

  31. Uridine diphosphate glucuronosyltransferase 1 family polypeptide A1 (UGT1A1) is a predictive biomarker for the side-effects of irinotecan chemotherapy, which reduces the volume of tumors harboring UGT1A1 polymorp...

    Authors: Hideki Matsuoka, Ryusuke Murakami, Kaoru Abiko, Ken Yamaguchi, Akihito Horie, Junzo Hamanishi, Tsukasa Baba and Masaki Mandai
    Citation: BMC Cancer 2020 20:729
    Content type: Research article Published on:

  32. Better biomarkers for assessing risk of relapse in stage I testicular germ cell tumor patients are needed, to complement classical histopathological variables. We aimed to assess the prognostic value of previo...

    Authors: João Lobo, Ad J. M. Gillis, Annette van den Berg and Leendert H. J. Looijenga
    Citation: BMC Cancer 2020 20:728
    Content type: Research article Published on:

  33. Anti-PD1 inhibitors have been approved for the treatment of recurrent or metastatic head and neck cancer (HNC), as a result of Global Phase III trials. However, the clinical outcomes of immune checkpoint inhib...

    Authors: Hyera Kim, Minsuk Kwon, Binnari Kim, Hyun Ae Jung, Jong-Mu Sun, Se-Hoon Lee, Keunchil Park and Myung-Ju Ahn
    Citation: BMC Cancer 2020 20:727
    Content type: Research article Published on:

  35. Previous reports indicate that the methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism plays a role in gastric cancer. However, whether it influences the development and progression of atrophic g...

    Authors: Siya Kong, Feng Ye, Yini Dang, Yifei Hua and Guoxin Zhang
    Citation: BMC Cancer 2020 20:725
    Content type: Research article Published on:

  36. Breast tumor initiating cells (BTIC) are stem-like cells that initiate and sustain tumor growth, and drive disease recurrence. Identifying therapies targeting BTIC has been hindered due primarily to their scar...

    Authors: William D. Gwynne, Mirza S. Shakeel, Adele Girgis-Gabardo, Kwang H. Kim, Emily Ford, Anna Dvorkin-Gheva, Craig Aarts, Methvin Isaac, Rima Al-awar and John A. Hassell
    Citation: BMC Cancer 2020 20:724
    Content type: Research article Published on:

  37. To evaluate the impact of Gallium-68 [68Ga] labeled prostate specific membrane antigen (PSMA) positron emission tomography (PET)/X-ray computed tomography (CT) compared with conventional imaging on staging and cl...

    Authors: Maarten L. Donswijk, Pim J. van Leeuwen, Erik Vegt, Zing Cheung, Stijn W. T. P. J. Heijmink, Henk G. van der Poel and Marcel P. M. Stokkel
    Citation: BMC Cancer 2020 20:723
    Content type: Research article Published on:

  38. There is a lack of firm knowledge regarding sexual problems and fertility-related distress in young adults following a diagnosis with cancer. Establishing such understanding is essential to identify patients i...

    Authors: L. Wettergren, L. Ljungman, C. Micaux Obol, L. E. Eriksson and C. Lampic
    Citation: BMC Cancer 2020 20:722
    Content type: Study protocol Published on:

  39. Hematopoietic cell transplantation (HCT) is a curative option for a growing number of patients with hematologic diseases and malignancies. However, HCT-related factors, such as total body irradiation used for ...

    Authors: Saro H. Armenian, Lanie Lindenfeld, Aleksi Iukuridze, Meagan Echevarria, Samantha Bebel, Catherine Coleman, Ryotaro Nakamura, Farah Abdullah, Badri Modi, Kevin C. Oeffinger, Karen M. Emmons, Ashfaq A. Marghoob and Alan C. Geller
    Citation: BMC Cancer 2020 20:721
    Content type: Study protocol Published on:

  42. To observe the medium- and long-term clinical efficacy and safety of radioactive 125I seed implantation for refractory malignant tumours based on CT-guided 3D template-assisted technique.

    Authors: Guang Sheng Zhao, Song Liu, Liang Yang, Chuang Li, Ruo Yu Wang, Jun Zhou and Yue Wei Zhang
    Citation: BMC Cancer 2020 20:718
    Content type: Research article Published on:

  43. Splenic marginal zone lymphoma (SMZL) is a rare lymphoid B-cell malignant neoplasm with primary involvement of the spleen. It is a chronic disease, of indolent behavior and prolonged survival. However, 25% of ...

    Authors: Luís Alberto de Pádua Covas Lage, Felipe Faganelli Caboclo dos Santos, Débora Levy, Frederico Rafael Moreira, Samuel Campanelli Freitas Couto, Hebert Fabrício Culler, Renata de Oliveira Costa, Vanderson Rocha and Juliana Pereira
    Citation: BMC Cancer 2020 20:717
    Content type: Research article Published on:

  44. The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and should be proposed in high-risk (HR) patients. Ho...

    Authors: Thomas Filleron, Sophie Le Guellec, Christine Chevreau, Bastien Cabarrou, Tom Lesluyes, Sabrina Lodin, Angélique Massoubre, Muriel Mounier, Muriel Poublanc, Frédéric Chibon and Thibaud Valentin
    Citation: BMC Cancer 2020 20:716
    Content type: Study protocol Published on:

  45. Single rare cell characterization represents a new scientific front in personalized therapy. Imaging mass cytometry (IMC) may be able to address all these questions by combining the power of MS-CyTOF and micro...

    Authors: Izhar S. Batth, Qing Meng, Qi Wang, Keila E. Torres, Jared Burks, Jing Wang, Richard Gorlick and Shulin Li
    Citation: BMC Cancer 2020 20:715
    Content type: Research article Published on:

  46. Diffuse large B-cell lymphoma (DLBCL) is a spectrum of disease comprising more than 30% of non-Hodgkin lymphomas. Although studies have identified several molecular subgroups, the heterogeneous genetic backgro...

    Authors: Wei Zhang, Li Yang, Yu’ Qi Guan, Ke’ Feng Shen, Mei’ Lan Zhang, Hao’ Dong Cai, Jia’ Chen Wang, Ying Wang, Liang Huang, Yang Cao, Na Wang, Xiao’ Hong Tan, Ken He Young, Min Xiao and Jian’ Feng Zhou
    Citation: BMC Cancer 2020 20:714
    Content type: Research article Published on:

  47. Studies have shown that abnormal changes of specific-gene DNA methylation in leukocytes may be associated with an elevated risk of cancer. However, associations between the methylation of the zinc-related genes,

    Authors: Anqi Ge, Song Gao, Yupeng Liu, Hui Zhang, Xuan Wang, Lei Zhang, Da Pang and Yashuang Zhao
    Citation: BMC Cancer 2020 20:713
    Content type: Research article Published on:

  48. Treatment with tumor-Infiltrating Lymphocytes (TIL) is an innovative therapy for advanced melanoma with promising clinical phase I/II study results and likely beneficial cost-effectiveness. As a randomized con...

    Authors: Melanie Lindenberg, Valesca Retèl, Maartje Rohaan, Joost van den Berg, John Haanen and Wim van Harten
    Citation: BMC Cancer 2020 20:712
    Content type: Research article Published on:

  49. Up to 75% of women diagnosed with breast cancer report chemotherapy-related cognitive changes (CRCC) during treatment, including decreased memory, attention, and processing speed. Though CRCC negatively impact...

    Authors: Jennifer Brunet, Meagan Barrett-Bernstein, Kendra Zadravec, Monica Taljaard, Nathalie LeVasseur, Amirrtha Srikanthan, Kelcey A. Bland, Barbara Collins, Julia W. Y. Kam, Todd C. Handy, Sherri Hayden, Christine Simmons, Andra M. Smith, Naznin Virji-Babul and Kristin L. Campbell
    Citation: BMC Cancer 2020 20:711
    Content type: Study protocol Published on:

  50. The evidence that albumin-bound paclitaxel (nab-paclitaxel) is safe and efficacious for the treatment of many types of malignant tumors is continuously increasing. However, the evidence and clinical data of na...

    Authors: Zhichao Tian, Fan Zhang, Po Li, Jiaqiang Wang, Jinpo Yang, Peng Zhang, Weitao Yao and Xin Wang
    Citation: BMC Cancer 2020 20:698
    Content type: Research article Published on:

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