Mesenchymal circulating tumor cells and Ki67: their mutual correlation and prognostic implications in hepatocellular carcinoma

Table 8 Multivariate analysis of clinicopathological characteristics associated with overall survival

Variable	HR	95% CI	P
Model 1
BCLC (B-C)	4.174	(2.402–7.253)	< 0.001
Tumor cap (complete)	0.602	(0.348–1.041)	0.069
M-CTC (positive)	1.115	(1.065–1.167)	< 0.001
MVI (positive)	1.978	(1.179–3.318)	0.010
Ki67 (≥ 50%)	1.666	(1.009–2.749)	0.046
Model 2
M-CTC + Ki67	2.885	(1.317–6.319)	0.008
AFP (≥ 400 ng/mL)	2.014	(1.077–3.764)	0.028
BCLC (B-C)	4.428	(1.881–10.424)	0.001

AFP alpha-fetoprotein, BCLC Barcelona Clinic Liver Cancer, CI confidence interval, HR hazard ratio, MVI microvascular invasion, M-CTC mesenchymal circulating tumor cell

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