Table 5 Comparison of clinicopathological characteristics between HCC patients with low (< 50%) or high (≥ 50%) Ki67 expression
Parameter | Ki67 expression | OR (95% CI) | P | |
|---|---|---|---|---|
Low (n = 66) | High (n = 39) | |||
Sex | ||||
Male | 56 (84.8) | 34 (87.2) | 1 | |
Female | 10 (15.2) | 5 (12.8) | 0.824 (0.259–2.614) | 0.742 |
Age (years) | ||||
< 45 | 26 (39.4) | 17 (43.6) | 1 | |
≥ 45 | 40 (60.6) | 22 (56.4) | 0.841 (0.377–1.877) | 0.673 |
HBsAg | ||||
Negative | 7 (10.6) | 5 (12.8) | 1 | |
Positive | 59 (89.4) | 34 (87.2) | 0.807 (0.238–2.740) | 0.731 |
HBV-DNA (IU/mL) | ||||
< 5.0 × 102 | 21 (53.8) | 9 (23.1) | 1 | |
≥ 5.0 × 102 | 45 (68.2) | 30 (76.9) | 1.556 (0.628–3.854) | 0.34 |
AFP (ng/mL) | ||||
< 400 | 35 (53.0) | 11 (28.2) | 1 | |
≥ 400 | 31 (47.0) | 28 (71.8) | 2.874 (1.230–6.714) | 0.015 |
Tumor size (cm) | ||||
< 5 | 20 (30.3) | 3 (7.7) | 1 | |
≥ 5 | 46 (69.7) | 36 (92.3) | 5.217 (1.437–18.944) | 0.012 |
Tumor number | ||||
Single | 39 (59.1) | 26 (66.7) | 1 | |
Multiple | 27 (40.9) | 13 (33.3) | 0.906 (0.598–1.372) | 0.640 |
Edmondson grade | ||||
I–II | 44 (66.7) | 19 (48.7) | 1 | |
III–IV | 22 (33.3) | 20 (51.3) | 1.968 (0.878–4.409) | 0.1 |
Tumor capsule | ||||
Incomplete | 15 (22.7) | 26 (66.7) | 1 | |
Complete | 51 (77.3) | 13 (33.3) | 0.147 (0.061–0.355) | < 0.001 |
MVI | ||||
Negative | 29 (43.9) | 4 (10.3) | 1 | |
Positive | 37 (56.1) | 35 (89.7) | 6.858 (2.187–21.508) | 0.001 |
PVTT | ||||
Negative | 58 (87.9) | 24 (61.5) | 1 | |
Positive | 8 (12.1) | 15 (38.5) | 4.531 (1.699–12.087) | 0.003 |
Liver cirrhosis | ||||
Negative | 3 (4.5) | 1 (2.6) | 1 | |
Positive | 63 (95.5) | 38 (97.4) | 1.810 (0.182–18.025) | 0.613 |
BCLC stage | ||||
0-A | 41 (62.1) | 16 (41.0) | 1 | |
B-C | 25 (37.9) | 23 (60.0) | 1.934 (1.174–3.185) | 0.01 |
VCE | ||||
Negative | 34 (51.5) | 7 (17.9) | 1 | |
Positive | 32 (48.5) | 32 (82.1) | 4.857 (1.879–12.555) | 0.001 |