Table 4 Comparison of clinicopathological characteristics between HCC patients positive or negative for M-CTC
Parameter | M-CTC status | OR (95% CI) | P | |
|---|---|---|---|---|
Negative (n = 55) | Positive (n = 50) | |||
Sex | ||||
Male | 46 (83.6) | 44 (88.0) | 1 | |
Female | 9 (16.4) | 6 (12.0) | 0.697 (0.229–2.120) | 0.525 |
Age (years) | ||||
< 45 | 21 (38.1) | 22 (44.0) | 1 | |
≥ 45 | 34 (61.9) | 28 (56.0) | 0.786 (0.361–1.714) | 0.545 |
HBsAg | ||||
Negative | 6 (10.9) | 6 (12.0) | 1 | |
Positive | 49 (89.1) | 44 (88.0) | 0.898 (0.270–2.989) | 0.861 |
HBV-DNA (IU/mL) | ||||
< 5.0 × 102 | 17 (30.9) | 13 (26.0) | 1 | |
≥ 5.0 × 102 | 38 (69.1) | 37 (74.0) | 1.273 (0.543–2.986) | 0.578 |
AFP (ng/mL) | ||||
< 400 | 31 (56.4) | 15 (30.0) | 1 | |
≥ 400 | 24 (43.6) | 35 (70.0) | 3.014 (1.346–6.749) | 0.007 |
Tumor size (cm) | ||||
< 5 | 17 (30.9) | 6 (12.0) | 1 | |
≥ 5 | 38 (69.1) | 44 (88.0) | 3.281 (1.175–9.161) | 0.023 |
Tumor number | ||||
Single | 42 (76.4) | 23 (46.0) | 1 | |
Multiple | 13 (23.6) | 27 (54.0) | 1.273 (0.543–2.986) | < 0.001 |
Edmondson grade | ||||
I–II | 39 (70.9) | 24 (48.0) | 1 | |
III–IV | 16 (29.1) | 26 (52.0) | 2.422 (1.092–5.372) | 0.03 |
Tumor capsule | ||||
Incomplete | 11 (20.0) | 30 (60.0) | 1 | |
Complete | 44 (80.0) | 20 (40.0) | 0.167 (0.070–0.398) | < 0.001 |
MVI | ||||
Negative | 22 (40.0) | 11(22.0) | 1 | |
Positive | 33 (60.0) | 39 (78.0) | 2.364 (1.001–5.583) | 0.05 |
PVTT | ||||
Negative | 49 (89.1) | 33 (66.0) | 1 | |
Positive | 6 (10.9) | 17 (34.0) | 4.207 (1.502–11.785) | 0.006 |
BCLC stage | ||||
0-A | 41 (74.6) | 16 (52.0) | 1 | |
B-C | 14 (25.4) | 34 (68.0) | 3.013 (1.733–5.238) | < 0.001 |
VCE | ||||
Negative | 26 (47.3) | 15 (30.0) | 1 | |
Positive | 29 (52.7) | 35 (70.0) | 2.092 (0.936–4.673) | 0.072 |