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Fig. 3 | BMC Cancer

Fig. 3

From: Primary head and neck cancer cell cultures are susceptible to proliferation of Epstein-Barr virus infected lymphocytes

Fig. 3

MDM2 inhibitor HDM201 targets BI-12-derived spheroid cells. A Representative dose-viability curve of HDM201 treatments, data is shown with mean ± SD (dot with error bar, n = 3), The half maximal inhibitory concentration (IC50) with 95% confidence interval was calculated in GraphPad Prism by the function of ‘log(inhibitor) vs. normalized response – Variable slope’, detailed data is shown in Suppl. Table S3, based on 3 independently performed experiments, the IC50 (mean) was determined as 41.44 ± 5.47 nM. B Upregulation of p53 pathway-associated genes p21, MDM2, TP53I3, Bcl-2 and Noxa upon HDM201 treatment for 48 h in a dose-dependent manner; ***p < 0.001; n = 3

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BMC Cancer

ISSN: 1471-2407

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