Fig. 6

Construction and validation of a nomogram based on the nAChR-based prognostic signature. A The nomogram was constructed using clinical variables and nAChR expression. According to the scores for different clinical variables (drinking status, gender, smoking, risk, grade, stage, and age), shown in the upper panel, the survival rate of smoking HNSCC patients was calculated and predicted as shown in the bottom panel; B Time-dependent calibration curves for the nomogram. The Grey curve represents the predictive performance of an ideal nomogram while other curves represent the performance of the actual nomogram for one-year OS (green), three-year OS (blue), and five-year OS (red); ROC curves for C one-year OS, D three-year OS, E five-year OS, and F seven-year OS; G The expression of α5 nAChR in HNSCC samples, *p < 0.05; H The expression of α5 nAChR in HNSCC samples with different smoking status, *p < 0.05, ns represents no significance