Fig. 1
From: Adjuvant effect of IRES-based single-stranded RNA on melanoma immunotherapy
CrPVIRES-ssRNA increases the number of antigen-presenting cells. C57BL/6 mice were intramuscularly injected with CrPVIRES-ssRNA, alum, and poly(I:C). Immune cells were analyzed in drain inguinal lymph nodes for 24 h. A Total number of cells in draining inguinal lymph nodes according to adjuvant (n = 3). B Total cell percentages of CD11c+ DCs (left) and B220+ B cells (right). C, D Efficacy of antigen uptake using FITC-conjugated Ova 12 h after immunization (n = 6). Quantitative plots (C) and graph (D) of flow cytometry. Data were represented as mean ± SD. Statistical significance was indicated by *p < 0.05, **p < 0.01, and ***p < 0.005. Ova: Ovalbumin