Xia Q, Zhang X, Chen Q, Chen X, Teng J, Wang C, Li M, Fan L. Down-regulation of tissue factor inhibits invasion and metastasis of non-small cell lung cancer. J Cancer. 2020;11(5):1195–202.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ferreira CA, Ehlerding EB, Rosenkrans ZT, Jiang D, Sun T, Aluicio-Sarduy E, Engle JW, Ni D, Cai W. (86/90)Y-Labeled Monoclonal Antibody Targeting Tissue Factor for Pancreatic Cancer Theranostics. Mol Pharm 2020.
Hoesel B, Mussbacher M, Dikorman B, Salzmann M, Assinger A, Hell L, Thaler J, Basilio J, Moser B, Resch U, et al. Androgen receptor dampens tissue factor expression via nuclear factor-kappaB and early growth response protein 1. J Thromb haemostasis: JTH. 2018;16(4):749–58.
Article
CAS
Google Scholar
Wang B, Xiong S, Hua Q, Chen C, Liao H, Chen L, Yao W, Wu D, Tao Z. Tissue factor is strongly expressed in pericarcinomatous tissue in patients with laryngeal carcinoma. Int J Clin Exp Pathol. 2015;8(10):13719–24.
CAS
PubMed
PubMed Central
Google Scholar
Chen X, Xie T, Fang J, Xue W, Tong H, Kang H, Wang S, Yang Y, Xu M, Zhang W. Quantitative in vivo imaging of tissue factor expression in glioma using dynamic contrast-enhanced MRI derived parameters. Eur J Radiol. 2017;93:236–42.
Article
PubMed
Google Scholar
Ryden L, Grabau D, Schaffner F, Jonsson PE, Ruf W, Belting M. Evidence for tissue factor phosphorylation and its correlation with protease-activated receptor expression and the prognosis of primary breast cancer. Int J Cancer. 2010;126(10):2330–40.
CAS
PubMed
PubMed Central
Google Scholar
Tieken C, Verboom MC, Ruf W, Gelderblom H, Bovee JV, Reitsma PH, Cleton-Jansen AM, Versteeg HH. Tissue factor associates with survival and regulates tumour progression in osteosarcoma. Thromb Haemost. 2016;115(5):1025–33.
Article
PubMed
PubMed Central
Google Scholar
Adesanya MA, Maraveyas A, Madden L. Differing mechanisms of thrombin generation in live haematological and solid cancer cells determined by calibrated automated thrombography. Blood Coagul Fibrinolysis. 2017;28(8):602–11.
Article
CAS
PubMed
Google Scholar
Gheldof D, Mullier F, Bailly N, Devalet B, Dogné J-M, Chatelain B, Chatelain C. Microparticle bearing tissue factor: a link between promyelocytic cells and hypercoagulable state. Thromb Res. 2014;133(3):433–9.
Article
CAS
PubMed
Google Scholar
Rousseau A, Van Dreden P, Khaterchi A, Larsen AK, Elalamy I, Gerotziafas GT. Procoagulant microparticles derived from cancer cells have determinant role in the hypercoagulable state associated with cancer. Int J Oncol. 2017;51(6):1793–800.
Article
CAS
PubMed
Google Scholar
Thomas GM, Panicot-Dubois L, Lacroix R, Dignat-George F, Lombardo D, Dubois C. Cancer cell–derived microparticles bearing P-selectin glycoprotein ligand 1 accelerate thrombus formation in vivo. J Exp Med. 2009;206(9):1913–27.
Article
CAS
PubMed
PubMed Central
Google Scholar
Reddel CJ, Tan CW, Chen VM. Thrombin generation and cancer: Contributors and consequences. Cancers. 2019;11(1):100.
Article
CAS
PubMed Central
Google Scholar
Wu M, Chen L, Xu T, Xu B, Jiang J, Wu C. Prognostic values of tissue factor and its alternatively splice transcripts in human gastric cancer tissues. Oncotarget. 2017;8(32):53137–45.
Article
PubMed
PubMed Central
Google Scholar
Sherief LM, Hassan TH, Zakaria M, Fathy M, Eshak EA, Bebars MA, Esh A. Tissue factor expression predicts outcome in children with neuroblastoma: A retrospective study. Oncol Lett. 2019;18(6):6347–54.
CAS
PubMed
PubMed Central
Google Scholar
Hu Z, Shen R, Campbell A, McMichael E, Yu L, Ramaswamy B, London CA, Xu T, Carson WE. 3rd: Targeting Tissue Factor for Immunotherapy of Triple-Negative Breast Cancer Using a Second-Generation ICON. Cancer Immunol Res. 2018;6(6):671–84.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nierodzik MLR, Kajumo F, Karpatkin S. Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo. Cancer Res. 1992;52(12):3267–72.
CAS
PubMed
Google Scholar
Zain J, Huang YQ, Feng XS, Nierodzik ML, Li JJ, Karpatkin S. Concentration-dependent dual effect of thrombin on impaired growth/apoptosis or mitogenesis in tumor cells. Blood. 2000;95(10):3133.
Article
CAS
PubMed
Google Scholar
Henrikson KP, Salazar SL, Fenton JW, Pentecost BT. Role of thrombin receptor in breast cancer invasiveness. Br J Cancer. 1999;79(3–4):401–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Even-Ram S, Uziely B, Cohen P, Grisaru-Granovsky S, Maoz M, Ginzburg Y, Reich R, Vlodavsky I, Bar-Shavit R. Thrombin receptor overexpression in malignant and physiological invasion processes. Nat Med. 1998;4(8):909–14.
Article
CAS
PubMed
Google Scholar
Xu Y, Gu Y, Keep RF, Heth J, Muraszko KM, Xi G, Hua Y. Thrombin up-regulates vascular endothelial growth factor in experimental gliomas. Neurol Res. 2009;31(7):759–65.
Article
CAS
PubMed
Google Scholar
Liu J, Schuff-Werner P, Steiner M. Thrombin/thrombin receptor (PAR-1)-mediated induction of IL-8 and VEGF expression in prostate cancer cells. Biochem Biophys Res Commun. 2006;343(1):183–9.
Article
CAS
PubMed
Google Scholar
Terasaki H, Shirasawa M, Otsuka H, Yamashita T, Uchino E, Hisatomi T, Sonoda S, Sakamoto T. Different Effects of Thrombin on VEGF Secretion, Proliferation, and Permeability in Polarized and Non-polarized Retinal Pigment Epithelial Cells. Curr Eye Res. 2015;40(9):936–45.
Article
CAS
PubMed
Google Scholar
Caunt M, Huang YQ, Brooks PC, Karpatkin S. Thrombin induces neoangiogenesis in the chick chorioallantoic membrane. J Thromb haemostasis: JTH. 2003;1(10):2097–102.
Article
CAS
Google Scholar
Fang X, Liao R, Yu Y, Li J, Guo Z, Zhu T: Thrombin Induces Secretion of Multiple Cytokines and Expression of Protease-Activated Receptors in Mouse Mast Cell Line. Mediators Inflamm 2019, 2019:4952131.
Liu X, Yu J, Song S, Yue X, Li Q. Protease-activated receptor-1 (PAR-1): a promising molecular target for cancer. Oncotarget. 2017;8(63):107334–45.
Article
PubMed
PubMed Central
Google Scholar
Rao JS, Gujrati M, Chetty C. Tumor-associated soluble uPAR-directed endothelial cell motility and tumor angiogenesis. Oncogenesis. 2013;2:e53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shetty S, Kumar A, Johnson AR, Pueblitz S, Holiday D, Raghu G, Idell S. Differential expression of the urokinase receptor in fibroblasts from normal and fibrotic human lungs. Am J Respir Cell Mol Biol. 1996;15(1):78–87.
Article
CAS
PubMed
Google Scholar
Postiglione L, Montuori N, Riccio A, Di Spigna G, Salzano S, Rossi G, Ragno P. The plasminogen activator system in fibroblasts from systemic sclerosis. Int J Immunopathol Pharmacol. 2010;23(3):891–900.
Article
CAS
PubMed
Google Scholar
Gussen H, Hohlstein P, Bartneck M, Warzecha KT, Buendgens L, Luedde T, Trautwein C, Koch A, Tacke F. Neutrophils are a main source of circulating suPAR predicting outcome in critical illness. J Intensive Care. 2019;7:26.
Article
PubMed
PubMed Central
Google Scholar
Alpizar-Alpizar W, Nielsen BS, Sierra R, Illemann M, Ramirez JA, Arias A, Duran S, Skarstein A, Ovrebo K, Lund LR, et al. Urokinase plasminogen activator receptor is expressed in invasive cells in gastric carcinomas from high- and low-risk countries. Int J Cancer. 2010;126(2):405–15.
Article
CAS
PubMed
Google Scholar
Nielsen BS, Rank F, Illemann M, Lund LR, Dano K. Stromal cells associated with early invasive foci in human mammary ductal carcinoma in situ coexpress urokinase and urokinase receptor. Int J Cancer. 2007;120(10):2086–95.
Article
CAS
PubMed
Google Scholar
Ulisse S, Baldini E, Sorrenti S, D’Armiento M. The urokinase plasminogen activator system: a target for anti-cancer therapy. Curr Cancer Drug Targets. 2009;9(1):32–71.
Article
CAS
PubMed
Google Scholar
Mauro CD, Pesapane A, Formisano L, Rosa R, D’Amato V, Ciciola P, Servetto A, Marciano R, Orsini RC, Monteleone F, et al. Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors. Sci Rep. 2017;7(1):9388.
Article
PubMed
PubMed Central
Google Scholar
Endo-Munoz L, Cai N, Cumming A, Macklin R, de Long LM, Topkas E, Mukhopadhyay P, Hill M, Saunders NA. Progression of osteosarcoma from a non-metastatic to a metastatic phenotype is causally associated with activation of an autocrine and paracrine uPA Axis. PLoS ONE. 2015;10(8):e0133592.
Article
PubMed
PubMed Central
Google Scholar
Praus M, Collen D, Gerard RD. Both u-PA inhibition and vitronectin binding by plasminogen activator inhibitor 1 regulate HT1080 fibrosarcoma cell metastasis. Int J Cancer. 2002;102(6):584–91.
Article
CAS
PubMed
Google Scholar
Aguirre Ghiso JA, Alonso DF, Farias EF, Gomez DE, de Kier Joffe EB. Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype. Eur J Biochem. 1999;263(2):295–304.
Article
CAS
PubMed
Google Scholar
Alfano D, Franco P, Vocca I, Gambi N, Pisa V, Mancini A, Caputi M, Carriero MV, Iaccarino I, Stoppelli MP. The urokinase plasminogen activator and its receptor: role in cell growth and apoptosis. Thromb Haemost. 2005;93(2):205–11.
Article
CAS
PubMed
Google Scholar
Blasi F, Carmeliet P. uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol. 2002;3(12):932–43.
Article
CAS
PubMed
Google Scholar
Nishi H, Sasaki T, Nagamitsu Y, Terauchi F, Nagai T, Nagao T, Isaka K. Hypoxia inducible factor-1 mediates upregulation of urokinase-type plasminogen activator receptor gene transcription during hypoxia in cervical cancer cells. Oncol Rep. 2016;35(2):992–8.
Article
CAS
PubMed
Google Scholar
Murphy G, Stanton H, Cowell S, Butler G, Knäuper V, Atkinson S, Gavrilovic J. Mechanisms for pro matrix metalloproteinase activation. Apmis. 1999;107(1):38–44.
Article
CAS
PubMed
Google Scholar
Xing RH, Rabbani SA. Overexpression of urokinase receptor in breast cancer cells results in increased tumor invasion, growth and metastasis. Int J Cancer. 1996;67(3):423–9.
Article
CAS
PubMed
Google Scholar
Christensen A, Kiss K, Lelkaitis G, Juhl K, Persson M, Charabi BW, Mortensen J, Forman JL, Sorensen AL, Jensen DH, et al. Urokinase-type plasminogen activator receptor (uPAR), tissue factor (TF) and epidermal growth factor receptor (EGFR): tumor expression patterns and prognostic value in oral cancer. BMC Cancer. 2017;17(1):572.
Article
PubMed
PubMed Central
Google Scholar
Lundbech M, Krag AE, Christensen TD, Hvas AM. Thrombin generation, thrombin-antithrombin complex, and prothrombin fragment F1 + 2 as biomarkers for hypercoagulability in cancer patients. Thromb Res. 2020;186:80–5.
Article
CAS
PubMed
Google Scholar
Soe G, Kohno I, Inuzuka K, Itoh Y, Matsuda M. A monoclonal antibody that recognizes a neo-antigen exposed in the E domain of fibrin monomer complexed with fibrinogen or its derivatives: its application to the measurement of soluble fibrin in plasma. 1996.
Kwaan HC. The plasminogen-plasmin system in malignancy. Cancer Metastasis Rev. 1992;11(3–4):291–311.
Article
CAS
PubMed
Google Scholar
Kılıc M, Yoldas O, Keskek M, Ertan T, Tez M, Gocmen E, Koc M. Prognostic value of plasma D-dimer levels in patients with colorectal cancer. Colorectal Dis. 2008;10(3):238–41.
Article
PubMed
Google Scholar
Xu L, He F, Wang H, Gao B, Wu H, Zhao S. A high plasma D-dimer level predicts poor prognosis in gynecological tumors in East Asia area: a systematic review and meta-analysis. Oncotarget. 2017;8(31):51551.
Article
PubMed
PubMed Central
Google Scholar
Asanuma K, Nakamura T, Hagi T, Okamoto T, Kita K, Nakamura K, Matsuyama Y, Yoshida K, Asanuma Y, Sudo A. Significance of coagulation and fibrinolysis markers for benign and malignant soft tissue tumors. BMC Cancer. 2021;21(1):364.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48(3):452–8.
Article
CAS
PubMed
Google Scholar
Biggerstaff JP, Weidow B, Dexheimer J, Warnes G, Vidosh J, Patel S, Newman M, Patel P. Soluble fibrin inhibits lymphocyte adherence and cytotoxicity against tumor cells: implications for cancer metastasis and immunotherapy. Clin Appl Thromb Hemost. 2008;14(2):193–202.
Article
CAS
PubMed
Google Scholar
Pavey S, Hawson G, Marsh N. Impact of the fibrinolytic enzyme system on prognosis and survival associated with non-small cell lung carcinoma. Blood Coagul Fibrinolysis. 2001;12(1):51–8.
Article
CAS
PubMed
Google Scholar
Den Ouden M, Ubachs JH, Stoot J, Van Wersch J. Thrombin-antithrombin III and D-dimer plasma levels in patients with benign or malignant ovarian tumours. Scand J Clin Lab Investig. 1998;58(7):555–60.
Article
Google Scholar
Seitz R, Rappe N, Kraus M, Immel A, Wolf M, Maasberg M, Egbring R, Pfab R, Havemann K. Activation of coagulation and fibrinolysis in patients with lung cancer: relation to tumour stage and prognosis. Blood coagulation & fibrinolysis: an international journal in haemostasis and thrombosis. 1993;4(2):249–54.
Article
CAS
Google Scholar
Ay C, Dunkler D, Pirker R, Thaler J, Quehenberger P, Wagner O, Zielinski C, Pabinger I. High D-dimer levels are associated with poor prognosis in cancer patients. Haematologica. 2012;97(8):1158–64.
Article
CAS
PubMed
PubMed Central
Google Scholar
Erdem S, Amasyali AS, Aytac O, Onem K, Issever H, Sanli O. Increased preoperative levels of plasma fibrinogen and D dimer in patients with renal cell carcinoma is associated with poor survival and adverse tumor characteristics. In: Urologic Oncology: Seminars and Original Investigations: 2014: Elsevier; 2014: 1031–1040.
Liu L, Zhang X, Yan B, Gu Q, Zhang X, Jiao J, Sun D, Wang N, Yue X. Elevated plasma D-dimer levels correlate with long term survival of gastric cancer patients. PloS one 2014, 9(3).
Altiay G, Ciftci A, Demir M, Kocak Z, Sut N, Tabakoglu E, Hatipoglu O, Caglar T. High plasma D-dimer level is associated with decreased survival in patients with lung cancer. Clin Oncol. 2007;19(7):494–8.
Article
CAS
Google Scholar
Li X, Shu K, Zhou J, Yu Q, Cui S, Liu J, Zhou R, Ding D. Preoperative Plasma Fibrinogen and D-dimer as Prognostic Biomarkers for Non-Muscle-Invasive Bladder Cancer. Clin Genitourin Cancer. 2020;18(1):11–9.e11.
Article
PubMed
Google Scholar
Liu C, Ning Y, Chen X, Zhu Q. D-Dimer level was associated with prognosis in metastatic colorectal cancer: A Chinese patients based cohort study. Medicine. 2020;99(7):e19243.
Article
PubMed
PubMed Central
Google Scholar
Liu HF, Wang JX, Zhang DQ, Lan SH, Chen QX. Clinical Features and Prognostic Factors in Elderly Ewing Sarcoma Patients. Med Sci Monit. 2018;24:9370–5.
Article
PubMed
PubMed Central
Google Scholar
Liu B, Li B, Zhou P, Yue W, Wang T, Wang J, Hu X, Zhang W, Chen J, Chen L. Prognostic value of pretreatment plasma D-dimer levels in patients with diffuse large B cell lymphoma (DLBCL). Clin Chim Acta. 2018;482:191–8.
Article
CAS
PubMed
Google Scholar
Taguchi O, Gabazza EC, Yoshida M, Yamakami T, Kobayashi H, Shima T. High plasma level of plasmin-alpha 2-plasmin inhibitor complex is predictor of poor prognosis in patients with lung cancer. Clin Chim Acta. 1996;244(1):69–81.
Article
CAS
PubMed
Google Scholar
Raj SD, Zhou X, Bueso-Ramos CE, Ravi V, Patel S, Benjamin RS, Vadhan-Raj S. Prognostic significance of elevated D-dimer for survival in patients with sarcoma. Am J Clin Oncol. 2012;35(5):462–7.
Article
PubMed
Google Scholar
Morii T, Mochizuki K, Tajima T, Ichimura S, Satomi K. D-dimer levels as a prognostic factor for determining oncological outcomes in musculoskeletal sarcoma. BMC Musculoskelet Disord. 2011;12(1):250.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xu K, Lou Y, Sun R, Liu Y, Li B, Li J, Huang Q, Wan W, Xiao J. Establishment of a Nomogram-Based Model for Predicting the Prognostic Value of Inflammatory Biomarkers and Preoperative D-Dimer Level in Spinal Ewing’s Sarcoma Family Tumors: A Retrospective Study of 83 Patients. World Neurosurg. 2019;121:e104–12.
Article
PubMed
Google Scholar
Morii T, Tajima T, Aoyagi T, Ichimura S. D-dimer Level Changes During Systemic Chemotherapy Can Predict Prognosis of High-grade Musculoskeletal Sarcoma Patients. Anticancer Res. 2015;35(12):6781–6.
CAS
PubMed
Google Scholar
Cates JMM. Performance Analysis of the American Joint Committee on Cancer 8th Edition Staging System for Retroperitoneal Sarcoma and Development of a New Staging Algorithm for Sarcoma-Specific Survival. Ann Surg Oncol. 2017;24(13):3880–7.
Article
PubMed
Google Scholar
Sbaraglia M, Dei Tos AP. The pathology of soft tissue sarcomas. Radiol Med. 2019;124(4):266–81.
Article
PubMed
Google Scholar
Stephens RW, Pöllänen J, Tapiovaara H, Leung KC, Sim P-S, Salonen E-M, Rønne E, Behrendt N, Danø K, Vaheri A. Activation of pro-urokinase and plasminogen on human sarcoma cells: a proteolytic system with surface-bound reactants. J Cell Biol. 1989;108(5):1987–95.
Article
CAS
PubMed
Google Scholar
Taubert H, Würl P, Greither T, Kappler M, Bache M, Lautenschläger C, Füssel S, Meye A, Eckert A, Holzhausen H. Co-detection of members of the urokinase plasminogen activator system in tumour tissue and serum correlates with a poor prognosis for soft-tissue sarcoma patients. Br J Cancer. 2010;102(4):731.
Article
CAS
PubMed
PubMed Central
Google Scholar
Choong PF, Fernö M, Åkerman M, Willén H, Långström E, Gustaeson P, Alvegård T, Rydholm A. Urokinase-plasminogen‐activator levels and prognosis in 69 soft‐tissue sarcomas. Int J Cancer. 1996;69(4):268–72.
Article
CAS
PubMed
Google Scholar
Oh F, Todhunter D, Taras E, Vallera DA, Borgatti A. Targeting egFr and uPAr on human rhabdomyosarcoma, osteosarcoma, and ovarian adenocarcinoma with a bispecific ligand-directed toxin. Clin pharmacology: Adv Appl. 2018;10:113.
Google Scholar
Pilbeam K, Wang H, Taras E, Bergerson RJ, Ettestad B, DeFor T, Borgatti A, Vallera DA, Verneris MR. Targeting pediatric sarcoma with a bispecific ligand immunotoxin targeting urokinase and epidermal growth factor receptors. Oncotarget. 2018;9(15):11938–47.
Article
PubMed
Google Scholar
Tsuge M, Osaki M, Sasaki R, Hirahata M, Okada F. SK-216, a Novel Inhibitor of Plasminogen Activator Inhibitor-1, Suppresses Lung Metastasis of Human Osteosarcoma. Int J Mol Sci. 2018;19(3):736.
Article
PubMed Central
Google Scholar