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Fig. 2 | BMC Cancer

Fig. 2

From: BMP and activin membrane-bound inhibitor regulate connective tissue growth factor controlling mesothelioma cell proliferation

Fig. 2

Knockdown of BAMBI suppresses MM cell proliferation and enhances CTGF expression. A, Bar graphs of relative expression levels of BAMBI in Y-MESO-14 and Y-MESO-27 cells transfected with a BAMBI siRNA (20 nM) and compared with BAMBI levels in non-transfected cells and cells transfect with control siRNA. B, Estimated numbers of viable Y-MESO-14 and Y-MESO-27 cells at 0, 24, 48, and 72 h after BAMBI siRNA transfection. C, Representative images of Y-MESO-14 and Y-MESO-27 cell after 72 h of transfection with BAMBI siRNA and control siRNA. Scale bar = 200 μm. D, Graphs of relative mRNA levels and western blots of CTGF levels in control cells and cells transfected BAMBI-targeted siRNA as measured by RT-qPCR and western blotting, respectively. All results are expressed as mean ± SD of three independent experiments (*p < 0.05 vs. control siRNA group by one-way ANOVA with post hoc Bonferroni tests for pair-wise comparisons)

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BMC Cancer

ISSN: 1471-2407

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