Fig. 4

Differentially expressed PSMs between 16 cancer types and corresponding normal tissue. A Bar chart visualizing the number of differentially expressed PSM genes between cancer and normal tissue. BRCA and LUSC showed the highest number of cancer-related PSMs (n = 45), whereas only 17 differentially expressed PSMs were identified in PCPG. B Bar chart depicting differential PSM gene expression patterns in various cancer types. Overexpression strongly dominated across all cancer types. C-D Box plot depicting differentially expressed PSMs in cancer and normal tissue. PSMB11 was found to be differentially expressed in 2/16 cancer types, while PSME3 was differentially expressed in all except one of the 16 cancer types. The Wilcoxon test was used to calculate statistical significance (Benjamini–Hochberg adjusted p-values) differences in expression (RSEM) between cancer and normal tissue. ns = not significant (P > 0.05); *P < 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001