Table 4 Comparison of the BRCA pathogenic variants in the populations of Hakka population and other populations at home and abroad

Asian

 Our data (Hakka)

c.2635G > T

c.3756_3759delGTCT

c.4065_4068delTCAA

c.5164_5165delAG

c.2339C > G

c.2806_2809delACAA

 Chinese

c.5470_5477delATTGGGCA

c.2612C > T

c.3548A > G

c.3109C > T

c.2806_2809delAAAC

c.5164_5165delAG

[25]

 Vietnamese

c.5251C > T

c.4997dup

No hotspot

[19]

 Indian

c.68_69delAG

c.5074 + 1G > A

c.3607C > T

c.5722_5723delCT

[10]

 Pakistani

c.4508C > A

c.4065_4068delTCAA

c.68_69delAG

c.3109C > T

c.4829_4830delTG

[20]

 Korean

c.390C > A

c.3627dupA

c.922_924delAGCinsT

c.7480C > T

c.1399A > T

c.5576_5579delTTAA

[21]

European

 Ashkenazi Jewish

c.68_69delAG

c.5266dupC

c.5946delT

[11]

 Polish

c.5266dupC

c.181 T > G

c.5251C > T

-

[16]

 Spanish

c.5123C > A

c.211A > G

-

c.2806_2809delAAAC

c.6024dupG

c.6275_6276delTT

[22]

 Italian

c.5266dupC

c.2406_2409delGAGT

c.5062_5064delGTT

c.6313delA

c.5722_5723delCT

-

[17]

 Latin America and the Caribbean populations

c.5123C > A

-

-

c.6174delT

-

-

[23]

 Ashkenazi Jewish in Argentina

c.68_69delAG

c.5266dupC

-

c.5946delT

-

-

[12]

 Southern Brazilian

c.5266dupC

c.5177_5180delGAAA

c.5251C > T

c.2808_2811delACAA

c.1138delA

-

[18]

 Peruvian

c.68_69delAG

-

-

c.2808_2811delACAA

-

-

[13]

African

 South African Indian

c.68_69delAG

c.4308_4309delTT

-

c.8754 + 1G > A

c.4003G > T

-

[14]

 South African

c.68_69delAG

c.1374delC

c.2641G > T

c.7934delG

c.5771_5774del

c.6448_6449dup

[15]

 North African

c.211dupA

c.798_799delTT

c.5266dupC

c.1310_1313delAAGA

-

-

[24]