Fig. 1

Networks construction using weighted gene co-expression network analysis (WGCNA). a the clustering tree of samples and matched clinical traits; brown blocks in ‘Gender’ refer to female, yellow to male samples; bule blocks in ‘TumorStage’ indicate LSCC patients in early stage, while turquoise represents advanced stage. b and c the soft threshold value was determined based on mean connectivity and scale-free fit. d The tumor stage of LSCC and modules relationships were depicted; digits in the boxes were the correlations (up) and corresponding P-value (down); e The cluster tree and identified modules were pictured. f The network heatmap plot of all genes