Cronin KA, Lake AJ, Scott S, Sherman RL, Noone AM, Howlader N, et al. Annual report to the nation on the status of cancer, part I: national cancer statistics. Cancer. 2018;124(13):2785–800.
Article
PubMed
Google Scholar
SEER Cancer Statistics Review, 1975–2017, National Cancer Institute, National Cancer Institute. 2019. https://seer.cancer.gov/csr/1975_2017/ . Accessed 30 April 2020.
Nakazawa K, Kurishima K, Tamura T, Kagohashi K, Ishikawa H, Satoh H, et al. Specific organ metastases and survival in small cell lung cancer. Oncol Lett. 2012;4(4):617–20.
Article
PubMed
PubMed Central
Google Scholar
Saintigny P, Burger JA. Recent advances in non-small cell lung cancer biology and clinical management. Discov Med. 2012;13(71):287–97.
PubMed
Google Scholar
Mardani A, Gheytanchi E, Mousavie SH, Madjd Jabari Z, Shooshtarizadeh T. Clinical significance of cancer stem cell markers CD133 and CXCR4 in osteosarcomas. Asian Pac J Cancer Prev. 2020;21(1):67–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gagliardi F, Narayanan A, Reni M, Franzin A, Mazza E, Boari N, et al. The role of CXCR4 in highly malignant human gliomas biology: current knowledge and future directions. Glia. 2014;62(7):1015–23.
Article
PubMed
Google Scholar
Ye C, Zhang C, Huang H, Yang B, Xiao G, Kong D, et al. The natural compound myricetin effectively represses the malignant progression of prostate cancer by inhibiting PIM1 and disrupting the PIM1/CXCR4 Interaction. Cell Physiol Biochem. 2018;48(3):1230–44.
Article
CAS
PubMed
Google Scholar
Shanmugam MK, Ahn KS, Hsu A, Woo CC, Yuan Y, Tan KHB, et al. Thymoquinone inhibits bone metastasis of breast cancer cells through abrogation of the CXCR4 signaling axis. Front Pharmacol. 2018;9:1294–327.
Article
CAS
PubMed
PubMed Central
Google Scholar
Weixler B, Renetseder F, Facile I, Tosti N, Cremonesi E, Tampakis A, et al. Phosphorylated CXCR4 expression has a positive prognostic impact in colorectal cancer. Cell Oncol. 2017;40(6):609–19.
Article
CAS
Google Scholar
Chatterjee S, Behnam Azad B, Nimmagadda S. The intricate role of CXCR4 in cancer. Adv Cancer Res. 2014;124:31–82.
Article
CAS
PubMed
PubMed Central
Google Scholar
Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature. 2001;410(6824):50–6.
Article
CAS
PubMed
Google Scholar
Spano JP, Andre F, Morat L, Sabatier L, Besse B, Combadiere C, et al. Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome. Ann Oncol. 2004;15(4):613–7.
Article
PubMed
Google Scholar
Song JS, Jung JK, Park JC, Kim DK, Jang SJ. Association of CXCR4 expression with metastasis and survival among patients with non-small cell lung cancer. Korean J Pathol. 2008;42(6):358–64.
Google Scholar
Wang M, Chen GY, Song HT, Hong X, Yang ZY, Sui GJ. Significance of CXCR4, phosphorylated STAT3 and VEGF-A expression in resected non-small cell lung cancer. Exp Ther Med. 2011;2(3):517–22.
Article
PubMed
PubMed Central
Google Scholar
Mao Y, Li W, Chen K, Xie Y, Liu Q, Yao M, et al. B7–H1 and B7–H3 are independent predictors of poor prognosis in patients with non-small cell lung cancer. Oncotarget. 2015;6(5):3452–61.
Article
PubMed
Google Scholar
Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–5.
Article
PubMed
Google Scholar
Suzuki M, Mohamed S, Nakajima T, Kubo R, Tian L, Fujiwara T, et al. Aberrant methylation of CXCL12 in non-small cell lung cancer is associated with an unfavorable prognosis. Int J Oncol. 2008;33(1):113–9.
CAS
PubMed
Google Scholar
Otsuka S, Klimowicz AC, Kopciuk K, Petrillo SK, Konno M, Hao D, et al. CXCR4 overexpression is associated with poor outcome in females diagnosed with stage IV non-small cell lung cancer. J Thorac Oncol. 2011;6(7):1169–78.
Article
PubMed
Google Scholar
Al Zobair AA, Al Obeidy BF, Yang L, Yang C, Hui Y, Yu H, et al. Concomitant overexpression of EGFR and CXCR4 is associated with worse prognosis in a new molecular subtype of non-small cell lung cancer. Oncol Rep. 2013;29(4):1524–32.
Article
CAS
PubMed
Google Scholar
Li Y, Shen Y, Miao Y, Luan Y, Sun B, Qiu X. Co-expression of uPAR and CXCR4 promotes tumor growth and metastasis in small cell lung cancer. Int J Clin Exp Pathol. 2014;7(7):3771–80.
PubMed
PubMed Central
Google Scholar
Li XX, Li RJ, Zhao LJ, Liu NB, Wang P. Expression of molecular factors correlated with metastasis in small cell lung cancer and their significance. Int J Clin Exp Pathol. 2015;8(11):14676–84.
CAS
PubMed
PubMed Central
Google Scholar
Kaemmerer D, Reimann C, Specht E, Wirtz RM, Sayeg M, Baum RP, et al. Differential expression and prognostic value of the chemokine receptor CXCR4 in bronchopulmonary neuroendocrine neoplasms. Oncotarget. 2015;6(5):3346–58.
Article
PubMed
Google Scholar
Zuo J, Wen M, Li S, Lv X, Wang L, Ai X, et al. Overexpression of CXCR4 promotes invasion and migration of non-small cell lung cancer via EGFR and MMP-9. Oncol Lett. 2017;14(6):7513–21.
PubMed
PubMed Central
Google Scholar
He L, Deng H, Liu S, Chen J, Li B, Wang C, et al. Overexpression of amplified in breast cancer 1 (AIB1) gene promotes lung adenocarcinoma aggressiveness in vitro and in vivo by upregulating C-X-C motif chemokine receptor 4. Cancer Commun. 2018;38(1):53–66.
Article
Google Scholar
Katsura M, Shoji F, Okamoto T, Shimamatsu S, Hirai F, Toyokawa G, et al. Correlation between CXCR4/CXCR7/CXCL12 chemokine axis expression and prognosis in lymph-node-positive lung cancer patients. Cancer Sci. 2018;109(1):154–65.
Article
CAS
PubMed
Google Scholar
Zhu Q, Luo R, Gu J, Hou Y, Chen Z, Xu F, et al. High CXCR4 expression predicts a poor prognosis in resected lung adenosquamous carcinoma. J Cancer. 2020;11(4):810–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wagner PL, Hyjek E, Vazquez MF, Meherally D, Liu YF, Chadwick PA, et al. CXCL12 and CXCR4 in adenocarcinoma of the lung: association with metastasis and survival. J Thorac Cardiovasc Surg. 2009;137(3):615–21.
Article
CAS
PubMed
Google Scholar
Su L, Zhang J, Xu H, Wang Y, Chu Y, Liu R, et al. Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells. Clin Cancer Res. 2005;11(23):8273–80.
Article
CAS
PubMed
Google Scholar
Na IK, Scheibenbogen C, Adam C, Stroux A, Ghadjar P, Thiel E, et al. Nuclear expression of CXCR4 in tumor cells of non-small cell lung cancer is correlated with lymph node metastasis. Hum Pathol. 2008;39(12):1751–5.
Article
CAS
PubMed
Google Scholar
Chen G, Wang Z, Liu XY, Liu FY. High-level CXCR4 expression correlates with brain-specific metastasis of non-small cell lung cancer. World J Surg. 2011;35(1):56–61.
Article
PubMed
Google Scholar
Zhou Z, Chen ZW, Yang XH, Shen L, Ai XH, Lu S, et al. Establishment of a biomarker model for predicting bone metastasis in resected stage III non-small cell lung cancer. J Exp Clin Cancer Res. 2012;31:34–9.
Article
PubMed
PubMed Central
CAS
Google Scholar
Wang L, Wang Z, Liu X, Liu F. High-level C-X-C chemokine receptor type 4 expression correlates with brain-specific metastasis following complete resection of non-small cell lung cancer. Oncol Lett. 2014;7(6):1871–6.
Article
PubMed
PubMed Central
Google Scholar
Bi MM, Shang B, Wang Z, Chen G. Expression of CXCR4 and VEGF-C is correlated with lymph node metastasis in non-small cell lung cancer. Thorac Cancer. 2017;8(6):634–41.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liu Y, Wu B, Geng H, Xu M, Zhong H. Association of chemokine and chemokine receptor expression with the invasion and metastasis of lung carcinoma. Oncol Lett. 2015;10(3):1315–22.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cong Z, Wu H, Guo Z, Qin T, Xu Y, Jing H, et al. High expression of C-X-C chemokine receptor 4 and Notch1 is predictive of lymphovascular invasion and poor prognosis in lung adenocarcinoma. Tumour Biol. 2017;39(6):1010428317708698.
Article
PubMed
CAS
Google Scholar
Takanami I. Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis. Int J Cancer. 2003;105(2):186–9.
Article
CAS
PubMed
Google Scholar
Wald O, Izhar U, Amir G, Avniel S, Bar-Shavit Y, Wald H, et al. CD4+CXCR4highCD69+ T cells accumulate in lung adenocarcinoma. J Immunol. 2006;177(10):6983–90.
Article
CAS
PubMed
Google Scholar
Shimizu K, Nakata M, Hirami Y, Yukawa T, Maeda A, Tanemoto K. Tumor-infiltrating Foxp3+ regulatory T cells are correlated with cyclooxygenase-2 expression and are associated with recurrence in resected non-small cell lung cancer. J Thorac Oncol. 2010;5(5):585–90.
Article
PubMed
Google Scholar
Franco R, Pirozzi G, Scala S, Cantile M, Scognamiglio G, Camerlingo R, et al. CXCL12-binding receptors expression in non-small cell lung cancer relates to tumoral microvascular density and CXCR4 positive circulating tumoral cells in lung draining venous blood. Eur J Cardiothorac Surg. 2012;41(2):368–75.
Article
PubMed
Google Scholar
Zhou Y, Cao HB, Li WJ, Zhao L. The CXCL12 (SDF-1)/CXCR4 chemokine axis: Oncogenic properties, molecular targeting, and synthetic and natural product CXCR4 inhibitors for cancer therapy. Chin J Nat Med. 2018;16(11):801–10.
CAS
PubMed
Google Scholar
Portella L, Bello A, Scala S. CXCL12 signaling in the tumor microenvironment. Adv Exp Med Biol. 2021;1302:51–70.
Article
PubMed
Google Scholar
Sterlacci W, Saker S, Huber B, Fiegl M, Tzankov A. Expression of the CXCR4 ligand SDF-1/CXCL12 is prognostically important for adenocarcinoma and large cell carcinoma of the lung. Virchows Arch. 2016;468(4):463–71.
Article
CAS
PubMed
Google Scholar
Economidou F, Antoniou K, Soufla G, Lasithiotaki I, Karagiannis K, Lymbouridou R, et al. Role of VEGF-stromal cell-derived factor-1alpha/CXCL12 axis in pleural effusion of lung cancer. J Recept Signal Transduct Res. 2010;30(3):154–60.
Article
CAS
PubMed
Google Scholar
Bertolini G, Cancila V, Tripodo C, Sozzi G, Lo Russo G, Fortunato O, et al. Cisplatin sustains lung cancer metastasis through the systemic activation of SDF-1/CXCR4 axis. J Thorac Oncol. 2019;14(10):S303-S.
Article
Google Scholar
Mortezaee K. CXCL12/CXCR4 axis in the microenvironment of solid tumors: a critical mediator of metastasis. Life sci. 2020;249:117534–42.
Article
CAS
PubMed
Google Scholar
Bai L, Guo C, Wu H, Kaye AD, Jin C, Deng L, et al. The prognostic value of C-X-C chemokine receptor 4 in non-small cell lung cancer: a meta-analysis. Int J Clin Exp Med. 2017;10(2):2285–95.
CAS
Google Scholar
Liu K, Bao C, Yao N, Miao C, Varlotto J, Sun Q, et al. Expression of CXCR4 and non-small cell lung cancer prognosis: a meta-analysis. Int J Clin Exp Med. 2015;8(5):7435–45.
PubMed
PubMed Central
Google Scholar
Stumpf C, Kaemmerer D, Neubauer E, Sänger J, Schulz S, Lupp A. Somatostatin and CXCR4 expression patterns in adenocarcinoma and squamous cell carcinoma of the lung relative to small cell lung cancer. J Cancer Res Clin Oncol. 2018;144(10):1921–32.
Article
CAS
PubMed
Google Scholar
Shim B, Jin M, Moon J, Park I, Ryu H. High cytoplasmic CXCR4 expression predicts prolonged survival in triple-negative breast cancer patients treated with adjuvant chemotherapy. J Pathol Transl Med. 2018;52(6):369–77.
Article
PubMed
PubMed Central
Google Scholar
Zeelenberg I, Ruuls-Van Stalle L, Roos E. Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma. J Clin Invest. 2001;108(2):269–77.
Article
CAS
PubMed
PubMed Central
Google Scholar
Saba N, Wang Y, Fu H, Koenig L, Khuri F, Shin D, et al. Association of cytoplasmic CXCR4 with loss of epithelial marker and activation of ERK1/2 and AKT signaling pathways in non-small-cell lung cancer. Clin Lung Cancer. 2017;18(3):e203–10.
Article
CAS
PubMed
Google Scholar
Wei Y, Wang X, Yang S, Zhou S, Zhang H. The expression and significance of tumor associated macrophages and CXCR4 in non-small cell lung cancer. J BUON. 2018;23(2):398–402.
Google Scholar
Zeng Y, Wang X, Yin B, Xia G, Shen Z, Gu W, et al. Role of the stromal cell derived factor-1/CXC chemokine receptor 4 axis in the invasion and metastasis of lung cancer and mechanism. J Thorac Dis. 2017;9(12):4947–59.
Article
PubMed
PubMed Central
Google Scholar
Jupiter D. Causal diagrams and multivariate analysis III: confound it! J Foot Ankle Surg. 2015;54(1):145–7.
Article
PubMed
Google Scholar
Paratore S, Banna GL, D’Arrigo M, Saita S, Iemmolo R, Lucenti L, et al. CXCR4 and CXCL12 immunoreactivities differentiate primary non-small-cell lung cancer with or without brain metastases. Cancer Biomark. 2011;10(2):79–89.
Article
CAS
PubMed
Google Scholar
Liao T, Chen W, Sun J, Zhang Y, Hu X, Yang S, et al. CXCR4 accelerates osteoclastogenesis induced by non-small cell lung carcinoma cells through self-potentiation and VCAM1 secretion. Cell Physiol Biochem. 2018;50(3):1084–99.
Article
CAS
PubMed
Google Scholar
Ben-Baruch A. Site-specific metastasis formation: chemokines as regulators of tumor cell adhesion, motility and invasion. Cell Adh Migr. 2009;3(4):328–33.
Article
PubMed
PubMed Central
Google Scholar
Liang Z, Zhang J, Zeng X, Gao J, Wu S, Liu T. Relationship between EGFR expression, copy number and mutation in lung adenocarcinomas. BMC Cancer. 2010;10:376–84.
Article
PubMed
PubMed Central
CAS
Google Scholar
Begley LA, Kasina S, Shah RB, Macoska JA. Signaling mechanisms coupled to CXCL12/CXCR4-mediated cellular proliferation are PTEN-dependent. Am J Clin Exp Urol. 2015;3(2):91–9.
PubMed
PubMed Central
Google Scholar
Rahimi M, George J, Tang C. EGFR variant-mediated invasion by enhanced CXCR4 expression through transcriptional and post-translational mechanisms. Int J Cancer. 2010;126(8):1850–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wu J, Liu Y, Ma Y, Wang R, Ji X, Zhang Y, et al. Interaction between CXCR4 and EGFR and downstream PI3K/AKT pathway in lung adenocarcinoma A549 cells and transplanted tumor in nude mice. Int J Clin Exp Pathol. 2020;13(2):132–41.
CAS
PubMed
PubMed Central
Google Scholar
Hendrix CW, Collier AC, Lederman MM, Schols D, Pollard RB, Brown S, et al. Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection. J Acquir Immune Defic Syndr. 2004;37(2):1253–62.
Article
CAS
PubMed
Google Scholar
Peled A, Tavor S. Role of CXCR4 in the pathogenesis of acute myeloid leukemia. Theranostics. 2013;3(1):34–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lee BC, Lee TH, Avraham S, Avraham HK. Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells. Mol Cancer Res. 2004;2(6):327–38.
Article
CAS
PubMed
Google Scholar
He W, Yang T, Gong XH, Qin RZ, Zhang XD, Liu WD. Targeting CXC motif chemokine receptor 4 inhibits the proliferation, migration and angiogenesis of lung cancer cells. Oncol Lett. 2018;16(3):3976–82.
PubMed
PubMed Central
Google Scholar
Xie S, Tu Z, Xiong J, Kang G, Zhao L, Hu W, et al. CXCR4 promotes cisplatin-resistance of non-small cell lung cancer in a CYP1B1-dependent manner. Oncol Rep. 2017;37(2):921–8.
Article
CAS
PubMed
Google Scholar
Zhu Q, Zhang Z, Lu C, Xu F, Mao W, Zhang K, et al. Gefitinib promotes CXCR4-dependent epithelial to mesenchymal transition via TGF-β1 signaling pathway in lung cancer cells harboring EGFR mutation. Clin Transl Oncol. 2020;22(8):1355–63.
Article
CAS
PubMed
Google Scholar
D’Alterio C, Buoncervello M, Ieranò C, Napolitano M, Portella L, Rea G, et al. Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1. J Exp Clin Canc Res. 2019;38(1):432–44.
Article
CAS
Google Scholar
Tahirovic YA, Pelly S, Jecs E, Miller EJ, Sharma SK, Liotta DC, et al. Small molecule and peptide-based CXCR4 modulators as therapeutic agents. A patent review for the period from 2010 to 2018. Expert Opin Ther Pat. 2020;30(2):87–101.
Article
CAS
PubMed
Google Scholar