Table 4 Combination index calculation using Chou and Talalay method in three TNBC cell lines
From: Synergistic anti-proliferative activity of JQ1 and GSK2801 in triple-negative breast cancer
JQ1 (nM) | GSK2801 (µM) | Combination Index | ||
|---|---|---|---|---|
MDA-MB-231 | HCC-1806 | SUM-159 | ||
25 | 10 | 0.2 | 1.2 | 2.9 |
50 | 10 | 0.2 | 1.0 | 3.6 |
125 | 10 | 0.0 | 0.7 | 3.6 |
250 | 10 | 0.0 | 0.4 | 1.3 |
500 | 10 | 0.0 | 0.2 | 0.4 |
1000 | 10 | 0.0 | 0.1 | 0.0 |
25 | 20 | 0.2 | 1.1 | 1.7 |
50 | 20 | 0.1 | 1.1 | 2.1 |
125 | 20 | 0.0 | 0.7 | 1.4 |
250 | 20 | 0.0 | 0.3 | 0.5 |
500 | 20 | 0.0 | 0.2 | 0.1 |
1000 | 20 | 0.0 | 0.1 | 0.0 |