Fig. 6
From: Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer
Increased Therapeutic Benefit in Extended MnNP Treatment Model. A Treatment schematic for extended MnNP treatment in the TBR5 tumor model. Changes in (B) ascites volume and (C) tumor weight at endpoint (n = 4, *p < 0.05, **p < 0.001). Flow cytometry gating on CD45−/SSChi cells revealed significant changes in the percent of tumor cells in the (D) ascites and (E) tumors. Cells gated on F4/80int/CD206+ revealed significant decreases in (F) the percent of M2-like TAMs and (G) the ratio of M2 (CD206+):M1 (CD206-) TAMs. The cells also revealed significant increases in (H) classical monocytes (F4/80int/Ly6C+/Ly6G-) in the ascites and (I) NK cells (CD3−/B220−/NKp46+) in the tumor (n = 4, *p < 0.05, **p < 0.001)