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Fig. 5 | BMC Cancer

Fig. 5

From: Normal and cancer fibroblasts differentially regulate TWIST1, TOX and cytokine gene expression in cutaneous T-cell lymphoma

Fig. 5

a Normal fibroblasts attenuates Th2 processes in MyLa cells: Expression of GATA3 is significantly suppressed in MyLa cells after co-culture with normal fibroblasts (GATA3: p < 0.02) as measured by RT-PCR, whereas co-culture of MyLa cells with MF fibroblasts does not show effect on GATA3 expression. Data represented here is the mean of three different experiment and paired t-test has been performed to calculate the p value. b, c Normal fibroblasts regulates cell growth in MyLa cells: b Expression of IL16 is significantly suppressed in MyLa cells after co-culture with normal fibroblast (p < 0.03) in a short term culture, whereas co-culture of MyLa cells with MF fibroblasts increases the expression of IL16 expression in a significant manner (p < 0.01) as measured by RT-PCR. c Expression of IL4 was suppressed in MyLa cells after co-culture with normal fibroblasts in a short term culture, whereas co-culture of MyLa cells with MF fibroblasts significantly increases the expression of IL4 expression (p < 0.02) as measured by RT-PCR. d Co-culture of MyLa cells with normal fibroblasts further suppresses MKI67 expression in MyLa cells whereas co-culture with MF fibroblasts does not show noticeable effect on MKI67 expression. Data represented here is the mean of three different experiments and paired t-test has been performed to calculate the p value

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