From: Distribution of chimeric antigen receptor-modified T cells against CD19 in B-cell malignancies
Adverse events | Grade | |||
---|---|---|---|---|
I | II | III | IV | |
Blood | ||||
 Decrease of leukocyte count |  | 3 | 5 | 3 |
 Decrease of lymphocyte count |  | 3 |  | 4 |
 Decrease of neutrophil count |  | 3 | 1 | 7 |
 Decrease of platelet count | 1 | 3 | 1 |  |
 Increase of C-reactive protein | 2 |  |  |  |
 Degree III leukocyte bone marrow suppression |  |  | 1 |  |
 Anemia | 2 | 3 | 2 |  |
 Increase of serum ferritin | 1 |  |  |  |
Liver | ||||
 Elevated Alanine aminotransferase | 1 |  |  |  |
 Elevated Aspartate aminotransferase | 1 |  |  |  |
Pain | ||||
 Pain in the jaws |  |  |  | 1 |
 Muscular soreness | 1 |  |  |  |
 Pain in the left ilium |  | 1 |  |  |
Immune globulin | ||||
 Decrease of immunoglobulin A | 3 |  |  |  |
 Decrease of immunoglobulin G | 3 |  |  |  |
 Decrease of immunoglobulin M | 3 |  |  |  |
Digestive tract | ||||
 Diarrhea |  | 2 |  |  |
 Gastrointestinal reaction | 1 |  |  |  |
 Sick |  |  | 1 |  |
 Vomit |  |  | 1 |  |
 Dental ulcer | 1 |  |  |  |
Respiratory tract | ||||
 Cough | 1 |  |  |  |
 Upper respiratory infection | 1 | 1 |  |  |
 Pneumonia |  |  | 3 |  |
Cardiovascular | ||||
 Nodal tachycardia | 2 |  |  |  |
Others | ||||
 Insomnia |  | 1 |  |  |
 Elevated urinary white blood cells |  | 1 |  |  |
 Feeble | 1 |  |  |  |
 Headache | 1 |  |  |  |
 Elevated thyroid stimulating hormone | 1 |  |  |  |