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Table 2 The allelic and genotypic distribution among control, CIN and cervical cancer groups of SNPs in ERAP1 gene

From: Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population

SNPs

Control (Freq)

CIN (Freq)

Cervical cancer (Freq)

Cervical cancer vs Control

 

CIN vs Control

 

Cervical cancer vs CIN

P-value

OR[95%CI]

P-value

OR[95%CI]

P-value

OR[95%CI]

rs27037

         

G

1372 (54.4%)

592 (53.2%)

1092 (50.9%)

0.020

1.147 [1.022–1.288]

0.532

1.046 [0.908–1.205]

0.212

1.097 [0.949–1.268]

T

1152 (45.6%)

520 (46.8%)

1052 (49.1%)

G/G

359 (28.4%)

161 (29.0%)

283 (26.4%)

0.020

 

0.323

 

0.462

 

G/T

654 (51.8%)

270 (48.6%)

526 (49.1%)

   

T/T

249 (19.8%)

125 (22.5%)

263 (24.5%)

   

rs27044

         

G

1350 (53.5%)

611 (54.9%)

1240 (57.8%)

0.003

0.838 [0.746–0.941]

0.416

0.943 [0.818–1.086]

0.114

0.889 [0.768–1.029]

C

1174 (46.5%)

501 (45.1%)

904 (42.2%)

G/G

362 (28.7%)

175 (31.5%)

360 (33.6%)

0.012

 

0.454

 

0.196

 

G/C

626 (49.6%)

261 (46.9%)

520 (48.5%)

   

C/C

274 (21.7%)

120 (21.6%)

192 (17.9%)

   

rs30187

         

C

1318 (52.2%)

589 (53.0%)

1203 (56.1%)

0.008

0.855 [0.761–0.960]

0.678

0.970 [0.843–1.118]

0.087

0.881 [0.762–1.019]

T

1206 (47.8%)

523 (47.0%)

941 (43.9%)

C/C

343 (27.2%)

169 (30.4%)

347 (32.4%)

0.020

 

0.151

 

0.134

 

C/T

632 (50.0%)

251 (45.1%)

509 (47.5%)

   

T/T

287 (22.8%)

136 (24.5%)

216 (20.1%)

   

rs26618

         

T

1852 (73.4%)

785 (70.6%)

1508 (70.3%)

0.021

1.162 [1.023–1.321]

0.083

1.148 [0.982–1.342]

0.879

1.012 [0.863–1.187]

C

672 (26.6%)

327 (29.4%)

636 (29.7%)

T/T

678 (53.7%)

285 (51.3%)

546 (50.9%)

0.016

 

0.076

 

0.989

 

C/T

496 (39.3%)

215 (38.7%)

416 (38.8%)

   

C/C

88 (7.0%)

56 (10.1%)

110 (10.3%)

   

rs26653

         

C

1227 (48.6%)

574 (51.6%)

1143 (53.3%)

0.001

0.829 [0.738–0.930]

0.095

0.887 [0.770–1.021]

0.359

0.934 [0.808–1.080]

G

1297 (51.4%)

538 (48.4%)

1001 (46.7%)

C/C

281 (22.3%)

142 (25.5%)

299 (27.9%)

0.004

 

0.224

 

0.591

 

G/C

665 (52.7%)

290 (52.2%)

545 (50.8%)

   

G/G

316 (25.0%)

124 (22.3%)

228 (21.3%)

   

rs3734016

         

C

2159 (85.5%)

947 (85.2%)

1801 (84.0%)

0.145

0.888 [0.756–1.041]

0.767

0.970 [0.795–1.184]

0.387

0.915 [0.748–1.119]

T

365 (14.5%)

165 (14.8%)

343 (16.0%)

      

C/C

921 (73.0%)

404 (72.7%)

752 (70.1%)

0.318

 

0.832

 

0.500

 

C/T

317 (25.1%)

139 (25.0%)

297 (27.7%)

      

T/T

24 (1.9%)

13 (2.3%)

23 (2.1%)

      
  1. Note: The statistical significant threshold was set at P < 0.0045 after Bonferroni correction