Fig. 6
From: Blocking podoplanin suppresses growth and pulmonary metastasis of human malignant melanoma
SZ168 restrains primary tumor development and spontaneous lung metastasis of C8161 cells in vivo. C8161 cells (1 × 106 cells) were inoculated subcutaneously into BALB/c nude mice. After 1 d, SZ168 or mouse IgG (30 μg/mouse) antibody was injected into the lateral tail vein of mice. (a) Gross morphology of the tumor xenografts. (b) Primary tumor growth. (c) Primary tumor weights. ***P < 0.001. (d) Numbers of metastatic foci of the lungs. **P < 0.01. Data are presented as mean ± SD from three independent experiments (n = 6)