Fig. 3
From: Blocking podoplanin suppresses growth and pulmonary metastasis of human malignant melanoma
SZ168 suppresses pulmonary metastasis in vivo. CHO/hPDPN cells were incubated with 30 μg SZ168 or mouse IgG. Cell suspensions were intravenously inoculated into BALB/c nude mice. (a) Comparison of the tumor sizes and tumor incidences in mice on day 30. (b) Representative pictures of the lungs. (c) Gross morphology of the tumors. (d) Lung weights. *P < 0.05. (e) Numbers of metastatic foci of the lungs. ***P < 0.001. (f) Tumor events. ***P < 0.001. Arrows indicate subcutaneous tumors. Data are presented as mean ± SD from three independent experiments (n = 6)