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Table 3 Summary of compound cytotoxicity in HeLa cells

From: The interactions of novel mononuclear platinum-based complexes with DNA

Compound

IC50 (μM)α

Drug concentration at which complete cell death was obtained (μM)

Cisplatin

9.3 ± 0.2

30

[Pt(RR-DACH)Cl2]

12.3 ± 4.0

100

[Pt(RR-DACP)Cl2]

6.9 ± 1.0

50

[Pt(SS-DACP)Cl2]

13.7 ± 2.0

50

[Pt(4FH)Cl2]

28.8 ± 1.6

>  200

  1. αThese IC50 values represent the drug concentration at which a cell viability of 50% was obtained and were determined by non-linear regression. Each IC50 value was determined from the average of three separate experimental values and is reported along with its corresponding SEM value