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Table 2 Summary of compound-induced unwinding of the SC I conformation of pUC19

From: The interactions of novel mononuclear platinum-based complexes with DNA

Compound

DNA unwinding angle (°)

Drug concentration at coalescence point (μM)α

rb(c) (drug: nucleotide at coalescence point)

Cisplatin

13

2.5 ± 0.0

1.0 × 10− 1 ± 2.0 × 10− 3

[Pt(RR-DACH)Cl2]

15.5 ± 1.9

2.2 ± 0.3

8.7 × 10− 2 ± 1.1 × 10− 2

[Pt(RR-DACP)Cl2]

16.9 ± 0.0

1.9 ± 0.0

7.8 × 10− 2 ± 2.0 × 10− 4

[Pt(SS-DACP)Cl2]

13.8 ± 0.6

2.4 ± 0.1

9.5 × 10− 2 ± 4.0 × 10− 3

[Pt(4FH)Cl2]

0.2 ± 0.0

184.5 ± 34.2

7.4 ± 1.4

  1. αThe drug concentration at the coalescence point indicates when the OC plasmid migrates at the same position as the SC I form. The rb (c) values represent the drug to nucleotide ratio at the coalescence point. For all experiments, the amount of nucleotide sample incubated with each compound was 1 × 10− 9 mol. All values in the table were averaged from three separate experiments and are shown with their respective SEM values
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BMC Cancer

ISSN: 1471-2407

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