From: The interactions of novel mononuclear platinum-based complexes with DNA
Compound | DNA unwinding angle (°) | Drug concentration at coalescence point (μM)α | rb(c) (drug: nucleotide at coalescence point) |
---|---|---|---|
Cisplatin | 13 | 2.5 ± 0.0 | 1.0 × 10− 1 ± 2.0 × 10− 3 |
[Pt(RR-DACH)Cl2] | 15.5 ± 1.9 | 2.2 ± 0.3 | 8.7 × 10− 2 ± 1.1 × 10− 2 |
[Pt(RR-DACP)Cl2] | 16.9 ± 0.0 | 1.9 ± 0.0 | 7.8 × 10− 2 ± 2.0 × 10− 4 |
[Pt(SS-DACP)Cl2] | 13.8 ± 0.6 | 2.4 ± 0.1 | 9.5 × 10− 2 ± 4.0 × 10− 3 |
[Pt(4FH)Cl2] | 0.2 ± 0.0 | 184.5 ± 34.2 | 7.4 ± 1.4 |