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Fig. 6 | BMC Cancer

Fig. 6

From: The interactions of novel mononuclear platinum-based complexes with DNA

Fig. 6

Images of 1.2% (v/v) denaturing agarose gels showing ssDNA or compound-induced cross-linked dsDNA. Denaturing agarose gels showing the large (2364 bp) PvuII-cleaved fragment of pUC19 following treatment with (a) cisplatin, (b) [Pt(RR-DACH)Cl2], (c) [Pt(RR-DACP)Cl2], (d) [Pt(SS-DACP)Cl2], and (e) [Pt(4FH)Cl2]. DMF control samples of non-heat denatured (dsDNA) and heat denatured (ssDNA) plasmid are present on the left and right-hand side of the 1 kb ladder, respectively. Bands to the right correspond to heat-denatured samples that were prior treated with increasing concentration of compound (values are indicated in μM above each gel image)

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