Prognostic effect of factors involved in revised Tokuhashi score system for patients with spinal metastases: a systematic review and Meta-analysis

Yang, Xiong-gang; Lun, Deng-xing; Hu, Yong-cheng; Liu, Yong-heng; Wang, Feng; Feng, Jiang-tao; Hua, Kun-chi; Yang, Li; Zhang, Hao; Xu, Ming-you; Zhang, Hao-ran

doi:10.1186/s12885-018-5139-2

Table 2 Summary of included studies

From: Prognostic effect of factors involved in revised Tokuhashi score system for patients with spinal metastases: a systematic review and Meta-analysis

Author	Character of studies						Character of patients
Author	Year	Study period	Study design	Country	Follow-up	NOS (Stars)	Primary tumor	Case	Case with MSCC	Male (%)	Age	Overall survival (median/mean)
van der Linden [9]	2005	1996–1998	retrospective cohort	Netherlands	≤32 m or until death	8	NI	342	12	53	mean: 66	median:7 m
Patchell [23]	2005	1992–2002	marched-pair study	USA	Median: surgery group: 3.4 m; radiation group: 3.1 m	9	NI	101	101	70	median: 60	NS
Chen [24]	2007	2000–2005	retrospective cohort	China	NS	8	NSCLC	31	31	61	mean: 61.4	median:8.8 m
Leithner [25]	2008	1998–2006	prospective+ retrospective cohort	Austria	≥12 m	7	NI	69	NS	54	mean: 60	median:14 m
Park [26]	2011	2001–2008	retrospective cohort	Korea	Mean: 25.8 m	8	NI	103	103	62	mean:54.6	median:10 m
Arrigo [27]	2011	1999–2009	retrospective cohort	USA	NS	9	NI	200	172	61	mean: 58.9	median:8 m
Rades [28]	2012	1992–2010	retrospective cohort	Germany	NS	8	NSCLC	356	356	74	median:64	NS
Crnalic [29]	2012	2003–2010	retrospective cohort	Sweden	NS	7	PCa	68	68	100	median:71	NS
Chong [30]	2012	2002–2010	retrospective cohort	Korea	NS	8	NI	105	105	69	mean:58.3	median:6 m
Rades [31]	2013	1992–2011	retrospective cohort	Germany	NS	8	NI	2029	2029	NS	NS	NS
Ju [32]	2013	2002–2011	retrospective cohort	USA	NS	8	PCa	27	27	100	median: 65	median:10.2 m
Bakker [33]	2014	2006–2013	retrospective cohort	Netherlands	NS	6	RCC	21	NS	NS	NS	median: 25 m
Bollen [34]	2014	2001–2010	retrospective cohort	Netherlands	Median: 6.6y	9	NI	1043	NS	52	mean:64.8	median:4.8 m
Vanek [35]	2015	2006–2012	retrospective cohort	Czech	NS	8	NI	166	166	NS	mean:62	median:16 m
Tang [36]	2015	2002–2013	retrospective cohort	China	Median: 13.5 m	9	NSCLC	116	116	65	median: 55	NS
Lei [18]	2015	2005–2015	retrospective cohort	China	Mean: 9.7 m	9	NSCLC	64	64	66	median:57	median:6.3 m
Chen [37]	2015	2000–2010	retrospective cohort	China	NS	8	NSCLC	50	50	68	mean: 61.6	median:7.5 m
Meng [38]	2016	2002–2012	retrospective cohort	China	NS	7	PCa	29	NS	100	median: 71	median: 44 m
Park [39]	2016	2010–2014	prospective cohort	Korea	NS	8	NSCLC	50	50	54	mean: 58.0	median:5.2 m
Huddart [40]	1997	1984–1992	retrospective cohort	UK	NS	8	PCa	69	69	100	NS	median: 3.8 m
North [8]	2005	NS	retrospective cohort	USA	NS	9	NI	61	NS	56	mean: 52.4	median:10 m
Williams [41]	2009	1993–2005	retrospective cohort	USA	NS	9	PCa	44	NS	100	median:68	median:5.4 m
Rades [42]	2012	1992–2010	retrospective cohort	Germany	NS	7	PCa	218	218	100	NS	NS
Crnalic [43]	2012	2003–2008	retrospective cohort	Sweden	Median: naïve: 26 m; refractory: 12 m	7	PCa	54	54	100	NS	NS
Lee [44]	2014	2005–2010	retrospective cohort	Korea	NS	7	NI	200	NS	59	mean: 59.9	mean: 10.8 m
Sellin [45]	2015	1993–2010	retrospective cohort	USA	NS	9	TCa	43	NS	60	NS	median:15.4 m
Drzymalski [46]	2010	1990–2009	retrospective cohort	USA	NS	8	PCa	333	77	100	median: 68	median:24 m
Tancioni [47]	2012	2004–2007	retrospective cohort	Italy	NS	9	NI	151	151	51	median: 62	median:14 m
Tatsui [48]	2014	1993–2007	retrospective cohort	USA	Median: 77.9 m	9	RCC	267	267	77	median:59.2	median:11.3 m
Petteys [49]	2016	2000–2011	retrospective cohort	USA	NS	8	RCC	30	NS	77	mean:57.6	median:11.4 m
Rades [50]	2016	NS	retrospective cohort	Germany	Median:6.5 m	7	TCa	14	14	29	median:70	NS
Kato [51]	2016	1984–2011	retrospective cohort	Japan	NS	7	TCa	32	NS	22	mean:60.6	median:6.4y
Sciubba [52]	2007	1993–2001	retrospective cohort	USA	Median: 13 m	9	BCa	87	NS	0	median: 53	median: 21 m
Walcott [53]	2011	2001–2009	retrospective cohort	USA	NS	7	BCa	15	15	0	median: 58	median: 34.2 m
Tancioni [54]	2011	2004–2009	retrospective cohort	Italy	Median:26 m	8	BCa	23	23	0	median:55	median:36 m
Zadnik [55]	2014	2002–2011	retrospective cohort	USA	Median:18.3 m	8	BCa	43	NS	0	median: 56	median:26.8 m
Ulmar [56]	2007	1984–2005	retrospective cohort	Germany	NS	6	RCC	37	20	84	median:64	mean:13.7 m
Jiang [57]	2014	1999–2013	retrospective cohort	China	Mean:42.7 m	7	TCa	21	NS	24	mean:62	NS
Oliveira [58]	2015	2010–2013	retrospective cohort	Brazil	mean: 13.8 m	7	NI	68	45	66	mean:62.2	NS
Kataoka [59]	2012	1990–2008	retrospective cohort	Japan	mean: 21 m	9	NI	143	NS	64	median:61	mean: 22 m
Aoude [60]	2016	2003–2012	retrospective cohort	Canada	NS	7	NI	126	NS	44	mean:59.2	mean:27 m
Bartels [61]	2007	1998–2005	retrospective cohort	Netherlands	NS	7	NI	219	185	58	mean:62.7	median:3 m
Lei [62]	2016	2005–2015	retrospective cohort	China	mean: 11.5 m	9	NI	206	206	51	median:56	median:7.3 m
Chang [63]	2001	1981–1997	retrospective cohort	China	NS	7	HCC	102	NS	93	mean:59.2	median:3 m
Chen [64]	2010	2001–2007	retrospective cohort	China	NS	7	HCC	41	NS	78	mean:53.2	mean:10.4 m
Choi [65]	2015	1992–2012	retrospective cohort	Korea	median:4.2 m	9	HCC	192	25	82	mean:56	median:4.5 m
Guo [66]	2003	1996–1998	retrospective cohort	USA	NS	6	NI	60	60	NS	NS	median:4.1 m
Moon [67]	2011	1987–2009	retrospective cohort	Korea	NS	6	NI	182	NS	61	median:56	median:8 m
Yang [68]	2012	2001–2009	retrospective cohort	Korea	NS	7	NI	217	NS	59	mean:55.5	median:6 m
Helweg-Larsen [69]	2000	a period of 3.5 years	prospective cohort	Denmark	≥11 m or until death	9	NI	153	153	51	NS	median:3.6 m
Kumar [70]	2014	2007–2011	retrospective cohort	Singapore	≥1y or until death	9	NPC	87	NS	78	median: 52	median:13 m
Mizumoto [71]	2008	2002–2006	retrospective cohort	Japan	≥1y or until death	9	NI	544	133	53	median:63	median:5.9 m
Ogihara [72]	2006	1993–2001	retrospective cohort	Japan	NS	7	LC	114	NS	61	mean:64.6	mean:6.2 m
Pointillart [11]	2011	2005–2007	prospective cohort	France	≥1y or until death	8	NI	142	NS	57	mean:61.8	median:5 m
Rades [73]	2006	1992–2003	retrospective cohort	Germany	NS	7	BCa	335	335	0	NS	median:20 m
Switlyk [76]	2015	2007–2008	retrospective cohort	Norway	NS	7	NI	173	47	56	median:65	median:8.2 m
Tao [74]	2004	1992–2002	retrospective cohort	China	≥6 m	9	NI	63	NS	59	mean:52	mean:6 m
Tomita [6]	2001	1987–1991	retrospective cohort	Japan	until 1992	7	NI	67	NS	46	mean:56.3	NS
Weber [76]	2013	NS	retrospective cohort	Germany	NS	6	BCa	145	145	0	median:63	NS
Yamashita [77]	2011	2006–2008	prospective cohort	USA	≥1y	9	NI	85	NS	52	mean:60.3	median:11.6 m
Yeung [78]	2014	2000–2010	retrospective cohort	China	≥1y	9	NI	128	128	71	mean:60.2; median:59	mean:7.6 m
Zhang [79]	2013	2003–2011	retrospective cohort	China	mean: 15.7 m	9	HCC	36	NS	89	mean:49.9	NS
Enkaoua [80]	1997	NS	retrospective cohort	France	NS	6	NI	71	NS	51	mean: 59.8	NS

Note: BCa = breast cancer; HCC = hepatocellular carcinoma; LC = lung cancer; MSCC = metastatic spinal cord compression; NI = not identified; NOS = The Newcastle-Ottawa Scale; NPC = nasopharyngeal carcinoma; NS = not specified; NSCLC = non-small cell lung cancer; OS% = percentage of overall survival; PCa = prostate cancer; RCC = renal cell cancer; RT = radiotherapy; SUR = surgery; TCa = thyroid cancer

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