Platta CS, Khuntia D, Mehta MP, Suh JH. Current treatment strategies for brain metastasis and complications from therapeutic techniques: a review of current literature. Am J Clin Oncol. 2010;33(4):398–407.
Article
PubMed
Google Scholar
Rivkin M, Kanoff RB. Metastatic brain tumors: current therapeutic options and historical perspective. The Journal of the American Osteopathic Association. 2013;113(5):418–23.
PubMed
Google Scholar
Leone JP, Leone BA. Breast cancer brain metastases: the last frontier. Experimental Hematology & Oncology. 2015;4(1):33.
Article
Google Scholar
Frisk G, Svensson T, Bäcklund LM, Lidbrink E, Blomqvist P, Smedby KE. Incidence and time trends of brain metastases admissions among breast cancer patients in Sweden. Br J Cancer. 2012;106(11):1850–3.
Article
CAS
PubMed
PubMed Central
Google Scholar
Adkins CE, Nounou MI, Mittapalli RK, Terrell-Hall TB, Mohammad AS, Jagannathan R, Lockman PR. A novel preclinical method to quantitatively evaluate early-stage metastatic events at the murine blood-brain barrier. Cancer prevention research (Philadelphia Pa). 2015;8(1):68–76.
Article
CAS
Google Scholar
Adkins CE, Mohammad AS, Terrell-Hall TB, Dolan EL, Shah N, Sechrest E, Griffith J, Lockman PR. Characterization of passive permeability at the blood–tumor barrier in five preclinical models of brain metastases of breast cancer. Clinical & Experimental Metastasis. 2016;33(4):373–83.
Article
CAS
Google Scholar
Lockman PR, Mittapalli RK, Taskar KS, Rudraraju V, Gril B, Bohn KA, Adkins CE, Roberts A, Thorsheim HR, Gaasch JA, et al. Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2010;16(23):5664–78.
Article
CAS
Google Scholar
Adkins CE, Nounou MI, Hye T, Mohammad AS, Terrell-Hall T, Mohan NK, Eldon MA, Hoch U, Lockman PR. NKTR-102 efficacy versus irinotecan in a mouse model of brain metastases of breast cancer. BMC Cancer. 2015;15:685.
Article
CAS
PubMed
PubMed Central
Google Scholar
Guillaume DJ, Doolittle ND, Gahramanov S, Hedrick NA, Delashaw JB, Neuwelt EA. Intra-arterial chemotherapy with osmotic blood-brain barrier disruption for aggressive Oligodendroglial tumors: results of a phase I study. Neurosurgery. 2010;66(1):48–58.
PubMed
Google Scholar
Konofagou EE, Tung Y-S, Choi J, Deffieux T, Baseri B, Vlachos F. Ultrasound-induced blood-brain barrier opening. Curr Pharm Biotechnol. 2012;13(7):1332–45.
Article
CAS
PubMed
PubMed Central
Google Scholar
El-Habashy SE, Nazief AM, Adkins CE, Wen MM, El-Kamel AH, Hamdan AM, Hanafy AS, Terrell TO, Mohammad AS, Lockman PR, et al. Novel treatment strategies for brain tumors and metastases. Pharmaceutical patent analyst. 2014;3(3):279–96.
Article
CAS
PubMed
Google Scholar
Mittapalli RK, Adkins CE, Bohn KA, Mohammad AS, Lockman JA, Lockman PR. Quantitative fluorescence microscopy measures vascular pore size in primary and metastatic brain tumors. Cancer Res. 2017;77(2):238–46.
Article
CAS
PubMed
Google Scholar
Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab. 1983;3(1):1–7.
Article
CAS
PubMed
Google Scholar
Asotra K, Ningaraj N, Black KL. Measurement of blood-brain and blood-tumor barrier permeabilities with [14C]-labeled tracers. Methods in molecular medicine. 2003;89:177–90.
PubMed
Google Scholar
Blasberg RG, Shapiro WR, Molnar P, Patlak CS, Fenstermacher JD. Local blood-to-tissue transport in Walker 256 metastatic brain tumors. J Neuro-Oncol. 1984;2(3):205–18.
CAS
Google Scholar
Eng LF, Ghirnikar RS, Lee YL. Glial fibrillary acidic protein: GFAP-thirty-one years (1969–2000). Neurochem Res. 2000;25(9):1439–51.
Article
CAS
PubMed
Google Scholar
Song L, Varma CA, Verhoeven JW, Tanke HJ. Influence of the triplet excited state on the photobleaching kinetics of fluorescein in microscopy. Biophys J. 1996;70(6):2959–68.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bohn KA, Adkins CE, Mittapalli RK, Terrell-Hall TB, Mohammad AS, Shah N, Dolan EL, Nounou MI, Lockman PR. Semi-automated rapid quantification of brain vessel density utilizing fluorescent microscopy. J Neurosci Methods. 2016;270:124–31.
Article
PubMed
PubMed Central
Google Scholar
Knight RA, Karki K, Ewing JR, Divine GW, Fenstermacher JD, Patlak CS, Nagaraja TN. Estimating blood and brain concentrations and blood-to-brain influx by magnetic resonance imaging with step-down infusion of Gd-DTPA in focal transient cerebral ischemia and confirmation by quantitative autoradiography with Gd-[(14)C]DTPA. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2009;29(5):1048–58.
Article
CAS
Google Scholar
Knight RA, Nagaraja TN, Ewing JR, Nagesh V, Whitton PA, Bershad E, Fagan SC, Fenstermacher JD. Quantitation and localization of blood-to-brain influx by magnetic resonance imaging and quantitative autoradiography in a model of transient focal ischemia. Magn Reson Med. 2005;54(4):813–21.
Article
CAS
PubMed
Google Scholar
van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE. Overcoming the blood-brain tumor barrier for effective glioblastoma treatment. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 2015;19:1–12.
Article
Google Scholar
Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000;407(6801):249–57.
Article
CAS
PubMed
Google Scholar
Fukumura D, Jain RK. Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. Microvasc Res. 2007;74(2–3):72–84.
Article
CAS
PubMed
PubMed Central
Google Scholar
Eilken HM, Adams RH. Dynamics of endothelial cell behavior in sprouting angiogenesis. Curr Opin Cell Biol. 2010;22(5):617–25.
Article
CAS
PubMed
Google Scholar
Schmitt M, Horbach A, Kubitz R, Frilling A, Haussinger D. Disruption of hepatocellular tight junctions by vascular endothelial growth factor (VEGF): a novel mechanism for tumor invasion. J Hepatol. 2004;41(2):274–83.
Article
CAS
PubMed
Google Scholar
Carmeliet P. VEGF as a key mediator of angiogenesis in cancer. Oncology. 2005;69(Suppl 3):4–10.
Article
CAS
PubMed
Google Scholar
Pardridge WM. Drug transport across the blood–brain barrier. J Cereb Blood Flow Metab. 2012;32(11):1959–72.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lipinski CA. Drug-like properties and the causes of poor solubility and poor permeability. J Pharmacol Toxicol Methods. 2000;44(1):235–49.
Article
CAS
PubMed
Google Scholar
Levin VA. Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J Med Chem. 1980;23(6):682–4.
Article
CAS
PubMed
Google Scholar
van de Waterbeemd H, Camenisch G, Folkers G, Chretien JR, Raevsky OA. Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors. J Drug Target. 1998;6(2):151–65.
Article
PubMed
Google Scholar
Fischer H, Gottschlich R, Seelig A. Blood-brain barrier permeation: molecular parameters governing passive diffusion. J Membr Biol. 1998;165(3):201–11.
Article
CAS
PubMed
Google Scholar
Uchida Y, Ohtsuki S, Katsukura Y, Ikeda C, Suzuki T, Kamiie J, Terasaki T. Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors. J Neurochem. 2011;117(2):333–45.
Article
CAS
PubMed
Google Scholar
Sharom FJ. ABC multidrug transporters: structure, function and role in chemoresistance. Pharmacogenomics. 2008;9(1):105–27.
Article
CAS
PubMed
Google Scholar
Hiesiger EM, Voorhies RM, Basler GA, Lipschutz LE, Posner JB, Shapiro WR. Opening the blood-brain and blood-tumor barriers in experimental rat brain tumors: the effect of intracarotid hyperosmolar mannitol on capillary permeability and blood flow. Ann Neurol. 1986;19(1):50–9.
Article
CAS
PubMed
Google Scholar
Walker MD, Weiss HD. Chemotherapy in the treatment of malignant brain tumors. Adv Neurol. 1975;13:149–91.
CAS
PubMed
Google Scholar
Blasberg RG, Gazendam J, Patlak CS, Shapiro WS, Fenstermacher JD. Changes in blood-brain transfer parameters induced by hyperosmolar intracarotid infusion and by metastatic tumor growth. Adv Exp Med Biol. 1980;131:307–19.
Article
CAS
PubMed
Google Scholar
Fidler IJ, Yano S, Zhang RD, Fujimaki T, Bucana CD. The seed and soil hypothesis: vascularisation and brain metastases. The Lancet Oncology. 2002;3(1):53–7.
Article
CAS
PubMed
Google Scholar
Langley RR, Fidler IJ. The biology of brain metastasis. Clin Chem. 2013;59(1):180–9.
Article
CAS
PubMed
Google Scholar
Baba H, Nakahira K, Morita N, Tanaka F, Akita H, Ikenaka K. GFAP gene expression during development of astrocyte. Dev Neurosci. 1997;19(1):49–57.
Article
CAS
PubMed
Google Scholar
Khurgel M, Ivy GO. Astrocytes in kindling: relevance to epileptogenesis. Epilepsy Res. 1996;26(1):163–75.
Article
CAS
PubMed
Google Scholar
Yang Z, Wang KK. Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker. Trends Neurosci. 2015;38(6):364–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Niranjan R, Nagarajan R, Hanif K, Nath C, Shukla R. LPS induces mediators of neuroinflammation, cell proliferation, and GFAP expression in human astrocytoma cells U373MG: the anti-inflammatory and anti-proliferative effect of guggulipid. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2014;35(3):409–14.
Article
Google Scholar
Hozumi I, Chiu FC, Norton WT. Biochemical and immunocytochemical changes in glial fibrillary acidic protein after stab wounds. Brain Res. 1990;524(1):64–71.
Article
CAS
PubMed
Google Scholar
Tsuji T, Shimohama S, Kamiya S, Sazuka T, Ohara O. Analysis of brain proteins in Alzheimer's disease using high-resolution two-dimensional gel electrophoresis. J Neurol Sci. 1999;166(2):100–6.
Article
CAS
PubMed
Google Scholar
Troost D, Sillevis Smitt PA, de Jong JM, Swaab DF. Neurofilament and glial alterations in the cerebral cortex in amyotrophic lateral sclerosis. Acta Neuropathol. 1992;84(6):664–73.
Article
CAS
PubMed
Google Scholar
Banati RB, Daniel SE, Blunt SB. Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. 1998;13(2):221–7.
Article
CAS
Google Scholar
Murayama S, Inoue K, Kawakami H, Bouldin TW, Suzuki K. A unique pattern of astrocytosis in the primary motor area in amyotrophic lateral sclerosis. Acta Neuropathol. 1991;82(6):456–61.
Article
CAS
PubMed
Google Scholar
Laurence JA, Fatemi SH. Glial fibrillary acidic protein is elevated in superior frontal, parietal and cerebellar cortices of autistic subjects. Cerebellum (London, England). 2005;4(3):206–10.
Article
CAS
Google Scholar
Singh VK, Warren R, Averett R, Ghaziuddin M. Circulating autoantibodies to neuronal and glial filament proteins in autism. Pediatr Neurol. 1997;17(1):88–90.
Article
CAS
PubMed
Google Scholar
Rosengren LE, Ahlsen G, Belfrage M, Gillberg C, Haglid KG, Hamberger A. A sensitive ELISA for glial fibrillary acidic protein: application in CSF of children. J Neurosci Methods. 1992;44(2–3):113–9.
Article
CAS
PubMed
Google Scholar
Aurell A, Rosengren LE, Karlsson B, Olsson JE, Zbornikova V, Haglid KG. Determination of S-100 and glial fibrillary acidic protein concentrations in cerebrospinal fluid after brain infarction. Stroke. 1991;22(10):1254–8.
Article
CAS
PubMed
Google Scholar
Hausmann R, Riess R, Fieguth A, Betz P. Immunohistochemical investigations on the course of astroglial GFAP expression following human brain injury. Int J Legal Med. 2000;113(2):70–5.
Article
CAS
PubMed
Google Scholar
Johnston-Wilson NL, Sims CD, Hofmann JP, Anderson L, Shore AD, Torrey EF, Yolken RH. Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium. Molecular psychiatry. 2000;5(2):142–9.
Article
CAS
PubMed
Google Scholar
Chumbalkar VC, Subhashini C, Dhople VM, Sundaram CS, Jagannadham MV, Kumar KN, Srinivas PN, Mythili R, Rao MK, Kulkarni MJ, et al. Differential protein expression in human gliomas and molecular insights. Proteomics. 2005;5(4):1167–77.
Article
CAS
PubMed
Google Scholar
Kovalchuk A, Kolb B: Chemo brain: from discerning mechanisms to lifting the brain fog-an aging connection. Cell Cycle (Georgetown, Tex) 2017:1–5.
Raffa RB. Is a picture worth a thousand (forgotten) words?: neuroimaging evidence for the cognitive deficits in 'chemo-fog'/'chemo-brain. J Clin Pharm Ther. 2010;35(1):1–9.
Article
CAS
PubMed
Google Scholar
Castellon SA, Ganz PA, Bower JE, Petersen L, Abraham L, Greendale GA. Neurocognitive performance in breast cancer survivors exposed to adjuvant chemotherapy and tamoxifen. J Clin Exp Neuropsychol. 2004;26(7):955–69.
Article
PubMed
Google Scholar
Schagen SB, van Dam FS, Muller MJ, Boogerd W, Lindeboom J, Bruning PF. Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma. Cancer. 1999;85(3):640–50.
Article
CAS
PubMed
Google Scholar
Ahles TA, Saykin AJ, Furstenberg CT, Cole B, Mott LA, Skalla K, Whedon MB, Bivens S, Mitchell T, Greenberg ER, et al. Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2002;20(2):485–93.
Article
CAS
Google Scholar
Kaiser J, Bledowski C, Dietrich J. Neural correlates of chemotherapy-related cognitive impairment. Cortex; a journal devoted to the study of the nervous system and behavior. 2014;54:33–50.
Article
PubMed
Google Scholar
Seigers R, Fardell JE. Neurobiological basis of chemotherapy-induced cognitive impairment: a review of rodent research. Neurosci Biobehav Rev. 2011;35(3):729–41.
Article
PubMed
Google Scholar
Seigers R, Loos M, Van Tellingen O, Boogerd W, Smit AB, Schagen SB. Cognitive impact of cytotoxic agents in mice. Psychopharmacology. 2015;232(1):17–37.
Article
CAS
PubMed
Google Scholar
Seigers R, Pourtau L, Schagen SB, van Dam FS, Koolhaas JM, Konsman JP, Buwalda B. Inhibition of hippocampal cell proliferation by methotrexate in rats is not potentiated by the presence of a tumor. Brain Res Bull. 2010;81(4–5):472–6.
Article
CAS
PubMed
Google Scholar
Seigers R, Timmermans J, van der Horn HJ, de Vries EF, Dierckx RA, Visser L, Schagen SB, van Dam FS, Koolhaas JM, Buwalda B. Methotrexate reduces hippocampal blood vessel density and activates microglia in rats but does not elevate central cytokine release. Behav Brain Res. 2010;207(2):265–72.
Article
CAS
PubMed
Google Scholar