Table 1 Mitochondrial apoptosis factors
Factor | From pathway | Effect on apoptosis |
|---|---|---|
Bad | AKT | Pro-apoptotic |
Bid | TRAIL | Pro-apoptotic |
Casp-12 | ER stress | Pro-apoptotic |
Noxa | p53 | Pro-apoptotic |
Puma | p53 | Pro-apoptotic |
Bim | JNK | Pro-apoptotic |
Mcl-1 | STAT3 and DNA damage | Anti-apoptotic |
A1 | nF κB | Anti-apoptotic |
Bak/Bax | Mitochondrial | Pro-apoptotic |
Bcl2 | Mitochondrial | Anti-apoptotic |
Bcl-XL | Mitochondrial | Anti-apoptotic |
XIAP | AKT | Anti-apoptotic |
ROS | STAT3, TRAIL, TNF α and ER stress | Pro-apoptotic |