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Table 1 Univariate analysis factors associated with PFS or OS

From: Classification of gallbladder cancer by assessment of CD8+ TIL and PD-L1 expression

  OS PFS
HR (95% CI)
P-value
HR (95% CI)
P-value
Clinical parameters
Age, (≤ 65 v >  65) 1.50 (0.84–2.67)
P = 0.170
1.39 (0.81–2.39)
P = 0.230
Sex, (Male v Female) 1.18 (0.68–2.06)
P = 0.559
1.061 (0.66–1.81)
P = 0.829
TNM stage, (I + II vs. III + IV) 2.76 (1.45–5.24)
P = 0.002
2.10 (1.18–3.73)
P = 0.012
Risk factors
 Gall stone (no v yes) 1.58 (0.89–2.81)
P = 0.117
1.47 (0.85–2.54)
P = 0.166
 Diabetes (no v yes) 1.27 (0.66–2.45)
P = 0.467
1.15 (0.64–2.05)
P = 0.640
 Hypertension (no v yes) 1.40 (0.77–2.52)
P = 0.270
1.50 (0.86–2.63)
P = 0.156
 Cholecystitis (no v yes) 1.34 (0.74–2.41)
P = 0.335
1.34 (0.77–2.35)
P = 0.304
Jaundice (no v yes) 2.82 (1.49–5.33)
P = 0.001
2.58 (1.35–4.92)
P = 0.004
Completed resection (no v yes) 0.38 (0.21–0.68)
P = 0.001
0.40 (0.22–0.72)
P = 0.002
CEA (>  5 μg/L) 1.97 (1.08–3.60)
P = 0.028
1.61 (0.90–2.89)
P = 0.110
CA19–9 (>  34 U/mL) 2.77 (1.52–5.06)
P = 0.001
2.28 (1.28–4.04)
P = 0.005
Liver dysfunction
 ALT (>  40 U/L) 2.13 (1.15–3.95)
P = 0.016
2.04 (1.10–3.79)
P = 0.023
 AST (>  35 U/L) 1.63 (0.91–2.91)
P = 0.099
1.34 (0.79–2.42)
P = 0.264
 TBil (>  22.2 μmol/L) 1.625 (0.91–2,90)
P = 0.101
1.38 (0.79–2.44)
P = 0.261
 DBil (>  6.8 μmol/L) 2.71 (1.50–4.91)
P = 0.001
2.45 (1.35–4.47)
P = 0.003
 GGT (>  45 U/L) 2.34 (1.31–4.17)
P = 0.004
2.055 (1.17–3.61)
P = 0.013
 ALP (>  135 U/L) 1.99 (1.12–3.56)
P = 0.020
1.75 (0.99–3.08)
P = 0.055
Pathological features
Differentiation (moderate vs. poor) 1.95 (1.10–3.46)
P = 0.023
1.57 (0.92–2.68)
P = 0.100
Mean tumor size (≤ 3.0 v > 3.0 cm) 1.07 (0.61–1.88)
P = 0.816
1.02 (0.60–1.72)
P = 0.955
Immunohistochemistry
 CD133+ in TCs 1.09 (0.62–1.91)
P = 0.776
0.99 (0.58–1.71)
P = 0.994
 CD8+ TILs (CD8low vs. CD8high) 0.49 (0.28–0.86)
P = 0.014
0.54 (0.31–0.93)
P = 0.026
 PD-1+ in TILs 1.14 (0.66–1.98)
P = 0.636
1.26 (0.74–2.13)
P = 0.398
 PD-L1+ in TCs 1.92 (0.95–3.88)
P = 0.067
1.87 (0.95–3.68)
P = 0.071
 PD-L1 vs. PD-L1+ 1.86 (1.04–3.33)
P = 0.038
1.60 (0.93–2.75)
P = 0.088
 PD-L2- vs. PD-L2+ 1.52 (0.82–2.80)
P = 0.185
1.40 (0.80–2.46)
P = 0.242
Classification based on PD-L1 expression and CD8+ TILs
 Overall NA; P = 0.003 NA; P = 0.018
 I vs. II 3.14 (1.11–8.85)
P = 0.031
2.40 (1.03–5.59)
P = 0.042
 I vs. III 3.36 (1.21–9.30)
P = 0.020
2.75 (1.16–6.51)
P = 0.021
 I vs. IV 7.38 (2.49–21.89)
< 0.001
4.81 (1.81–12.78)
P = 0.002
  1. NOTE: Univariate analysis, Cox proportional hazards regression model