Table 1 BRCA1 mutations in 140 TNBC specimens

1

2

c.185_187delAG

fs39X

<50 y

Yes

2

5

c.300 T > G

p.C61G

>50 y

n.a.

3

5

c.300 T > G

p.C61G

<50 y

n.a.

4

5

c.331 + 1G > T

Splice defect

>50 y

n.a

5

7

c.560 + 1delG^b

Splice defect

>50 y

No

6

11

c.2035 T > A

p.L639X

>50 y

Yes

7

11

c.3600del11

fs1163X

<50 y

n.a.

8

11

c.3600del11

fs1163X

<50 y

Yes

9

11

c.3600del11

fs1163X

>50 y

No

10

11

c.3819del5

fs1242X

<50 y

Yes

11

11

c.3875del4

fs1262X

<50 y

n.a.

12

11

c.3875del4

fs1262X

>50 y

n.a.

13

16

c.5007G > T^b

p.E1630X

<50 y

n.a.

14

19

c.5298A > T

p.K1727X

<50 y

Yes

15

20

c.5370C > T

p.R1751X

<50 y

Proven somatic^c

16

20

c.5385–5386insC

fs1829X

<50 y

n.a.

17

20

c.5385–5386insC

fs1829X

>50 y

n.a

18

21

IVS21 + 1G > T

Splice defect

<50 y

n.a.