Table 3 Differences in transcript levels in colorectal mucosa between poor and good responders to 5-FU-based chemotherapy. Transcript levels of 5-FU pathway genes were compared in mucosas of patients in the testing set divided into groups of poor responders (n = 13) and good responders (n = 13) to the first line chemotherapy regimens based on 5-FU

DPYD

0.76

0.31–1.69

0.259

DPYS

0.91

0.10–6.89

0.434

PPAT

0.88

0.20–3.63

0.086

RRM2

0.31

0.11–1.46

0.038

RRM1

0.59

0.22–1.18

0.014

SLC29A1

0.76

0.17–2.73

0.369

TK1

0.87

0.18–3.66

0.157

TYMP

0.56

0.12–2.46

0.130

TYMS

0.82

0.15–3.77

0.121

UCK1

0.85

0.23–1.96

0.369

UCK2

0.74

0.17–2.42

0.681

UMPS

0.68

0.23–1.21

0.024

UPB1

0.91

0.26–2.85

0.479

UPP1

0.61

0.16–2.10

0.106