Fig. 9

The possibility of development of a new alternative strategy that can utilize COX-2 or 5-LO activity itself in cancer cells. Considering our observation that DHEA and NALA produced more ROS through the 5-LO pathway than AA, we suggest the possibility of development of a new alternative strategy that can utilize COX-2 or 5-LO activity itself in cancer cells but is different from direct inhibition of COX-2 or 5-LO