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Fig. 1 | BMC Cancer

Fig. 1

From: 5-lipoxygenase mediates docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine-induced reactive oxygen species production and inhibition of proliferation of head and neck squamous cell carcinoma cells

Fig. 1

DHEA and NALA effectively inhibit cell proliferation and induce cell death in HNSCC cell lines. a Cells were treated with 20 μM of DHEA, EPEA and NALA. At 72 h, cells were subjected to cell proliferation assay. b SNU-1041 and SNU-1076 were treated with 20 μM of DHEA and NALA. At 60 h, cells were subjected to Annexin-V staining assay. c SNU-1041 and SNU-1076 were treated with DHEA (20 μM) and NALA (20 μM) plus AM251 (2 μM) or cay10448 (2 μM). At 72 h, cells were subjected to cell proliferation assay. Results are expressed as a percentage relative to control (% of control). P values were based on comparison with control (*P < 0.001, **P < 0.05) or DHEA/NALA-treated group (#P < 0.05)

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