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Table 4 Mean blood cells and coagulation parameters in dogs 29 days after the start date

From: GMP-grade α-TEA lysine salt: a 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs

   Vehicle 100 mg/kg 300 mg/kg 1500 mg/kg Unit
   Mean SD N Mean SD N Mean SD N Mean SD N  
Males Erythrocytes              
 Red blood cells 6.238 0.841 4 6.438 0.598 4 6.21 0.143 4 6.418 0.437 4 M/ul
 Hemoglobin 14.55 1.91 4 14.55 1.1 4 6.21 0.143 4 6.418 0.437 4 g/L
 Hematocrit 42.1 6.09 4 42.18 3.27 4 41.05 1.04 4 41.7 2.79 4 %
 Mean corpuscular volume 67.45 1.1 4 65.63 1.51 4 66.08 2.16 4 65 1.75 4 fL
 Mean corpuscular hemoglobin 23.35 0.24 4 22.68 0.59 4 22.9 0.64 4 22.73 0.7 4 pg
 Mean corpuscular hemoglobin concentration 34.6 0.47 4 34.6 0.37 4 34.63 0.33 4 34.9 0.51 4 g/dL
 Reticulocytes 42.73 11.31 4 58.65 15.92 4 46 11.97 4 24.55 3.67 4 109/L
Leukocytes              
 White blood cells 7.438 0.919 4 9.23 1.25 4 12.23 3.277 4 11.91 3.574 4 K/uL
 Neutrophils 4.183 0.937 4 4.805 0.658 4 7.438 3.162 4 7.193 2.464 4 K/uL
 Lymphocytes 2.593 0.442 4 3.438 0.597 4 3.56 0.326 4 3.655 0.792 4 K/uL
 Monocytes 0.43 0.153 4 0.683 0.089 4 0.825 0.26 4 0.565 0.14 4 K/uL
 Eosinophils 0.095 0.039 4 0.178 0.055 4 0.223 0.101 4 0.388 0.328 4 K/uL
 Basophils 0.098 0.078 4 0.1 0.018 4 0.138 0.038 4 0.08 0.026 4 K/uL
Thrombocytes              
 platelets 259.8 64 4 281.8 44.7 4 369.5 87.3 4 262.3 75.2 4 K/uL
 Mean platelet volume 10.95 1.11 4 9.88 0.8 4 9 0.87 4 8.6 0.77 4 fL
 Protrombin time 6.78 0.05 4 7.08 0.19 4 6.85 0.17 4 6.9 0.24 4 Seconds
 Activated partial thromboplastin time 12.68 1.16 4 12.7 0.84 4 13.5 0.88 4 13.05 1.28 4 Seconds
 Fibrinogen 254.5 42.7 4 288.5 18.9 4 289.5 85.4 4 414.5 89.9 4 mg/dL
Females Erythrocytes              
 Red blood cells 6.33 0.241 4 6.895 0.563 4 6.72 0.306 4 6.773 0.383 4 M/ul
 Hemoglobin 14.85 1 4 16.43 1.7 4 15.55 1.1 4 15.78 0.8 4 g/L
 Hematocrit 43.33 3.14 4 47.68 4.73 4 45.48 3.24 4 45.98 2.05 4 %
 Mean corpuscular volume 68.33 2.53 4 69.1 1.14 4 67.83 3.07 4 67.88 1.6 4 fL
 Mean corpuscular volume hemoglobin 23.45 0.71 4 23.83 0.55 4 23.15 1 4 23.3 0.55 4 pg
 Mean corpuscular hemoglobin concentration 34.25 0.47 4 69.3 23.65 4 72.85 24.88 4 45.75 23.65 4 g/dL
 Reticulocytes 34.25 0.47 4 34.5 0.24 4 34.23 0.35 4 34.3 0.46 4 109/L
Leukocytes              
 White blood cells 8.81 3.586 4 9.75 2.4 4 9.743 1.237 4 13.31 1.721 4 K/uL
 Neutrophils 5.293 3.009 4 4.928 1.273 4 5.32 1.312 4 8.193 1.654 4 K/uL
 Lymphocytes 2.693 0.318 4 3.575 0.702 4 3.358 0.543 4 3.985 0.625 4 K/uL
 Monocytes 0.548 0.218 4 0.495 0.071 4 0.648 0.083 4 0.665 0.281 4 K/uL
 Eosinophils 0.163 0.111 4 0.505 0.467 4 0.273 0.1 4 0.3 0.124 4 K/uL
 Basophils 0.078 0.022 4 0.175 0.027 4 0.105 0.019 4 0.123 0.051 4 K/uL
Thrombocytes              
 platelets 275.8 62.7 4 301.3 31.9 4 294.3 79 4 340 72.2 4 K/uL
 Mean platelet volume 13.03 2.23 4 10.45 0.79 4 10.85 0.97 4 9.75 0.71 4 fL
 Prothrombin time 7.1 0.18 4 7.18 0.15 4 6.8 0.22 4 6.93 0.19 4 Seconds
 Activated partial thromboplastin time 12.23 0.72 4 12.68 0.92 4 13.48 0.4 4 12.45 0.47 4 Seconds
 Fibrinogen 206 11.1 4 178.5 16.3 4 251.5 68.3 4 275.8 58.8 4 mg/dL
  1. Male and female dogs received indicated doses of α-TEA lysine salt daily for 28 days. After 28 daily treatments, blood was collected from 4 dogs per treatment group and analyzed for blood cells and coagulation parameters