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Table 4 Mean blood cells and coagulation parameters in dogs 29 days after the start date

From: GMP-grade α-TEA lysine salt: a 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs

  

Vehicle

100 mg/kg

300 mg/kg

1500 mg/kg

Unit

  

Mean

SD

N

Mean

SD

N

Mean

SD

N

Mean

SD

N

 

Males

Erythrocytes

             

 Red blood cells

6.238

0.841

4

6.438

0.598

4

6.21

0.143

4

6.418

0.437

4

M/ul

 Hemoglobin

14.55

1.91

4

14.55

1.1

4

6.21

0.143

4

6.418

0.437

4

g/L

 Hematocrit

42.1

6.09

4

42.18

3.27

4

41.05

1.04

4

41.7

2.79

4

%

 Mean corpuscular volume

67.45

1.1

4

65.63

1.51

4

66.08

2.16

4

65

1.75

4

fL

 Mean corpuscular hemoglobin

23.35

0.24

4

22.68

0.59

4

22.9

0.64

4

22.73

0.7

4

pg

 Mean corpuscular hemoglobin concentration

34.6

0.47

4

34.6

0.37

4

34.63

0.33

4

34.9

0.51

4

g/dL

 Reticulocytes

42.73

11.31

4

58.65

15.92

4

46

11.97

4

24.55

3.67

4

109/L

Leukocytes

             

 White blood cells

7.438

0.919

4

9.23

1.25

4

12.23

3.277

4

11.91

3.574

4

K/uL

 Neutrophils

4.183

0.937

4

4.805

0.658

4

7.438

3.162

4

7.193

2.464

4

K/uL

 Lymphocytes

2.593

0.442

4

3.438

0.597

4

3.56

0.326

4

3.655

0.792

4

K/uL

 Monocytes

0.43

0.153

4

0.683

0.089

4

0.825

0.26

4

0.565

0.14

4

K/uL

 Eosinophils

0.095

0.039

4

0.178

0.055

4

0.223

0.101

4

0.388

0.328

4

K/uL

 Basophils

0.098

0.078

4

0.1

0.018

4

0.138

0.038

4

0.08

0.026

4

K/uL

Thrombocytes

             

 platelets

259.8

64

4

281.8

44.7

4

369.5

87.3

4

262.3

75.2

4

K/uL

 Mean platelet volume

10.95

1.11

4

9.88

0.8

4

9

0.87

4

8.6

0.77

4

fL

 Protrombin time

6.78

0.05

4

7.08

0.19

4

6.85

0.17

4

6.9

0.24

4

Seconds

 Activated partial thromboplastin time

12.68

1.16

4

12.7

0.84

4

13.5

0.88

4

13.05

1.28

4

Seconds

 Fibrinogen

254.5

42.7

4

288.5

18.9

4

289.5

85.4

4

414.5

89.9

4

mg/dL

Females

Erythrocytes

             

 Red blood cells

6.33

0.241

4

6.895

0.563

4

6.72

0.306

4

6.773

0.383

4

M/ul

 Hemoglobin

14.85

1

4

16.43

1.7

4

15.55

1.1

4

15.78

0.8

4

g/L

 Hematocrit

43.33

3.14

4

47.68

4.73

4

45.48

3.24

4

45.98

2.05

4

%

 Mean corpuscular volume

68.33

2.53

4

69.1

1.14

4

67.83

3.07

4

67.88

1.6

4

fL

 Mean corpuscular volume hemoglobin

23.45

0.71

4

23.83

0.55

4

23.15

1

4

23.3

0.55

4

pg

 Mean corpuscular hemoglobin concentration

34.25

0.47

4

69.3

23.65

4

72.85

24.88

4

45.75

23.65

4

g/dL

 Reticulocytes

34.25

0.47

4

34.5

0.24

4

34.23

0.35

4

34.3

0.46

4

109/L

Leukocytes

             

 White blood cells

8.81

3.586

4

9.75

2.4

4

9.743

1.237

4

13.31

1.721

4

K/uL

 Neutrophils

5.293

3.009

4

4.928

1.273

4

5.32

1.312

4

8.193

1.654

4

K/uL

 Lymphocytes

2.693

0.318

4

3.575

0.702

4

3.358

0.543

4

3.985

0.625

4

K/uL

 Monocytes

0.548

0.218

4

0.495

0.071

4

0.648

0.083

4

0.665

0.281

4

K/uL

 Eosinophils

0.163

0.111

4

0.505

0.467

4

0.273

0.1

4

0.3

0.124

4

K/uL

 Basophils

0.078

0.022

4

0.175

0.027

4

0.105

0.019

4

0.123

0.051

4

K/uL

Thrombocytes

             

 platelets

275.8

62.7

4

301.3

31.9

4

294.3

79

4

340

72.2

4

K/uL

 Mean platelet volume

13.03

2.23

4

10.45

0.79

4

10.85

0.97

4

9.75

0.71

4

fL

 Prothrombin time

7.1

0.18

4

7.18

0.15

4

6.8

0.22

4

6.93

0.19

4

Seconds

 Activated partial thromboplastin time

12.23

0.72

4

12.68

0.92

4

13.48

0.4

4

12.45

0.47

4

Seconds

 Fibrinogen

206

11.1

4

178.5

16.3

4

251.5

68.3

4

275.8

58.8

4

mg/dL

  1. Male and female dogs received indicated doses of α-TEA lysine salt daily for 28 days. After 28 daily treatments, blood was collected from 4 dogs per treatment group and analyzed for blood cells and coagulation parameters