| Cases | HR (95 % CI)b |  | Cases | HR (95 % CI)b |  | Cases | HR (95 % CI)b |
---|---|---|---|---|---|---|---|---|
Aspirin | ||||||||
Duration of use, y | Frequency of use, per week | Pill-years of use, py | ||||||
<5 | 1830 | 1. (Ref.) | No use | 1483 | 1. (Ref.) | <0.75 | 1489 | 1. (Ref.) |
5- < 10 | 132 | 0.83 (0.69–1.02) | <4 | 71 | 0.87 (0.68–1.13) | 0.75- < 14 | 191 | 1.09 (0.94–1.28) |
10- < 20 | 97 | 0.95 (0.76–1.19) | 4- < 7 | 82 | 1.14 (0.9–1.43) | 14- < 49 | 266 | 0.97 (0.85–1.11) |
≥ 20 | 59 | 0.93 (0.70–1.24) | ≥ 7 | 481 | 1.07 (0.95–1.21) | ≥ 49 | 172 | 0.95 (0.81–1.12) |
P c | Â | 0.386 | P c | Â | 0.202 | P c | Â | 0.593 |
Low dose aspirin | ||||||||
Duration of use, y | Frequency of use, per week | Pill-years of use, py | ||||||
<1 | 1978 | 1. (Ref.) | No use | 1708 | 1. (Ref.) | <0.75 | 1711 | 1. (Ref.) |
1- < 5 | 90 | 0.86 (0.72–1.11) | <7 | 61 | 0.99 (0.76–1.29) | 0.75- < 21 | 203 | 1.07 (0.92–1.24) |
≥ 5 | 50 | 0.88 (0.65–1.2) | ≥ 7 | 349 | 1.05 (0.91–1.2) | ≥ 21 | 204 | 0.93 (0.8–1.08) |
P c | Â | 0.240 | P c | Â | 0.539 | P c | Â | 0.541 |
Regular strength aspirin | ||||||||
Duration of use, y | Frequency of use, per week | Pill-years of use, py | ||||||
<1 | 1965 | 1. (Ref.) | No use | 1866 | 1. (Ref.) | <0.75 | 1870 | 1. (Ref.) |
1- < 5 | 45 | 0.76 (0.55–1.06) | <7 | 94 | 0.99 (0.77–1.26) | 0.75- < 21 | 92 | 0.98 (0.79–1.21) |
≥ 5 | 108 | 0.98 (0.77–1.25) | ≥ 7 | 156 | 1.12 (0.92–1.36) | ≥ 21 | 156 | 1.03 (0.87–1.22) |
P c | Â | 0.726 | P c | Â | 0.590 | P c | Â | 0.775 |
COXibs d | ||||||||
Duration of use, y | Frequency of use, per week | Pill-years of use, py | ||||||
<1 | 1954 | 1. (Ref.) | No use | 1901 | 1. (Ref.) | <0.75 | 1904 | 1. (Ref.) |
1- < 5 | 134 | 1.06 (0.76–1.43) | <7 | 42 | 1.19 (0.82–1.72) | 0.75- < 21 | 139 | 1.05 (0.88–1.25) |
≥ 5 | 30 | 0.71 (0.46–1.09) | ≥ 7 | 175 | 0.95 (0.73–1.24) | ≥ 21 | 75 | 0.86 (0.68–1.09) |
P c | Â | 0.205 | P c | Â | 0.590 | P c | Â | 0.431 |
Non-aspirin, non-COXib NSAIDs | ||||||||
Duration of use, y | Frequency of use, per week | Pill-years of use, py | ||||||
<5 | 1845 | 1. (Ref.) | No use | 1462 | 1. (Ref.) | No use | 1470 | 1. (Ref.) |
5- < 10 | 128 | 1.05 (0.86–1.28) | <4 | 156 | 1.04 (0.87–1.26) | <4 | 248 | 0.94 (0.85–1.11) |
10- < 20 | 99 | 0.85 (0.7–1.06) | 4- < 7 | 130 | 1.13 (0.93–1.37) | 4- < 7 | 241 | 1.02 (0.89–1.17) |
≥ 20 | 46 | 0.92 (0.68–1.25) | ≥ 7 | 369 | 0.90 (0.79–1.02) | ≥ 7 | 159 | 0.84 (0.71–0.99) |
P c | Â | 0.260 | P c | Â | 0.144 | P c | Â | 0.130 |