Fig. 1
From: Genomic profiling of CHEK2*1100delC-mutated breast carcinomas
Hierarchical clustering of immune signature mRNA data and correlation with TILs. a, hierarchical clustering of mean centered, standardized immune signature gene expression data. Samples in the blue branch are regarded as high TIL (red: relative high expression, green: relative low expression), and are discarded from further analyses. Top row indicates mutation status (red: BRCA1, blue: BRCA2, green: CHEK2, grey: BRCAX), bottom row indicates intrinsic subtype (grey: luminal, black: basal). b, correlation plot for immune signature mRNA values and TIL percentages as determined by an experienced pathologist (rs = 0.74, p-value < 0.001), colors represent mutation status