Subtype | Overall survival | Breast cancer specific survival | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Alive | Death | HR (95 % CI) | p value | Adjust HR (95 % CI) | p value | Alive | Death | HR (95 % CI) | p value | Adjust HR (95 % CI) | p value |
ER and/or PR + and HER 2 - |  |  |  |  |  |  |  |  |  |  |  |  |
 No. of participants | 19674 | 1420 |  |  |  |  | 20248 | 846 |  |  |  |  |
 Underweight BMI | 659(3.35) | 47(3.31) | 1.17(0.87-1.57) | 0.2902 | 1.26(0.94-1.69) | 0.1269 | 678(3.35) | 28(3.31) | 1.17(0.80-1.71) | 0.4239 | 1.24(0.85-1.82) | 0.2684 |
 Normal BMI | 13352(67.87) | 827(58.24) | 1.00 |  | 1.00 |  | 13686(67.59) | 493(58.27) | 1.00 |  | 1.00 |  |
 Overweight BMI | 4901(24.91) | 462(32.54) | 1.48(1.32-1.66) | <0.0001 | 1.32(1.18-1.48) | <0.0001 | 5084(25.11) | 279(32.98) | 1.49(1.29-1.73) | 0.0035 | 1.30(0.96-1.76) | 0.0874 |
 Obese BMI | 762(3.87) | 84(5.92) | 1.74(1.39-2.18) | <0.0001 | 1.48(1.18-1.85) | 0.0006 | 800(3.95) | 46(5.44) | 1.57(1.16-2.12) | <0.0001 | 1.31(1.13-1.52) | 0.0003 |
ER and/or PR + and HER 2 + |  |  |  |  |  |  |  |  |  |  |  |  |
 No. of participants | 3691 | 427 |  |  |  |  | 3851 | 267 |  |  |  |  |
 Underweight BMI | 130(3.52) | 14(3.28) | 0.95(0.56-1.62) | 0.8463 | 1.07(0.63-1.83) | 0.802 | 139(3.61) | 5(1.87) | 0.54(0.22-1.31) | 0.1737 | 0.61(0.25-1.48) | 0.2705 |
 Normal BMI | 2612(70.77) | 297(69.56) | 1.00 |  | 1.00 |  | 2726(70.79) | 183(68.54) | 1.00 |  | 1.00 |  |
 Overweight BMI | 827(22.41) | 102(23.89) | 1.06(0.85-1.33) | 0.5960 | 1.02(0.81-1.28) | 0.875 | 856(22.23) | 73(27.34) | 1.24(0.95-1.63) | 0.1177 | 1.18(0.90-1.55) | 0.2251 |
 Obese BMI | 122(3.31) | 14(3.28) | 1.05(0.61-1.79) | 0.8608 | 0.94(0.55-1.61) | 0.8193 | 130(3.38) | 6(2.25) | 0.72(0.32-1.62) | 0.4277 | 0.62(0.27-1.39) | 0.2449 |
ER and PR - and HER 2 + | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 No. of participants | 3349 | 538 |  |  |  |  | 3551 | 336 |  |  |  |  |
 Underweight BMI | 94(2.81) | 27(5.02) | 1.79(1.21-2.65) | 0.0034 | 1.67(1.12-2.47) | 0.0113 | 103(2.90) | 18(5.36) | 1.88(1.16-3.05) | 0.0099 | 1.79(1.11-2.90) | 0.0179 |
 Normal BMI | 2288(68.32) | 344(63.94) | 1.00 |  | 1.00 |  | 2418(68.09) | 214(63.69) | 1.00 |  | 1.00 |  |
 Overweight BMI | 847(25.29) | 141(26.21) | 1.09(0.90-1.33) | 0.3926 | 0.94(0.77-1.14) | 0.5093 | 900(25.34) | 88(26.19) | 1.09(0.85-1.40) | 0.4921 | 0.93(0.73-1.19) | 0.5715 |
 Obese BMI | 120(3.58) | 26(4.83) | 1.38(0.93-2.06) | 0.1132 | 1.18(0.79-1.76) | 0.4247 | 130(3.66) | 16(4.76) | 1.35(0.81-2.24) | 0.2496 | 1.16(0.70-1.93) | 0.5683 |
ER and PR - and HER 2 - | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 No. of participants | 6424 | 1012 |  |  |  |  | 6770 | 666 |  |  |  |  |
 Underweight BMI | 215(3.35) | 34(3.36) | 1.09(0.77-1.54) | 0.6222 | 1.19(0.84-1.68) | 0.3333 | 225(3.32) | 24(3.60) | 1.14(0.76-1.72) | 0.5347 | 1.27(0.84-1.92) | 0.2606 |
 Normal BMI | 4206(65.47) | 610(60.28) | 1.00 |  | 1.00 |  | 4402(65.02) | 414(62.16) | 1.00 |  | 1.00 |  |
 Overweight BMI | 1727(26.88) | 311(30.73) | 1.20(1.05-1.38) | 0.0080 | 1.07(0.93-1.23) | 0.3301 | 1849(27.31) | 189(28.38) | 1.07(0.90-1.27) | 0.4398 | 0.93(0.79-1.11) | 0.4320 |
 Obese BMI | 276(4.30) | 57(5.63) | 1.37(1.04-1.80) | 0.0234 | 1.18(0.90-1.55) | 0.2395 | 294(4.34) | 39(5.86) | 1.38(0.99-1.91) | 0.0571 | 1.16(0.84-1.61) | 0.3749 |
Unknown | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 No. of participants | 3415 | 1071 |  |  |  |  | 3777 | 709 |  |  |  |  |
 Underweight BMI | 131(3.84) | 36(3.36) | 0.98(0.70-1.37) | 0.8923 | 1.11(0.79-1.55) | 0.5528 | 139(3.68) | 28(3.95) | 1.16(0.79-1.70) | 0.44 | 1.29(0.87-1.89) | 0.2010 |
 Normal BMI | 2308(67.58) | 675(63.03) | 1.00 |  | 1.00 |  | 2542(67.30) | 441(62.20) | 1.00 |  | 1.00 |  |
 Overweight BMI | 862(25.24) | 303(28.29) | 1.18(1.03-1.35) | 0.0153 | 1.12(0.98-1.28) | 0.1042 | 962(25.47) | 203(28.63) | 1.20(1.02-1.42) | 0.0283 | 1.15(0.97-1.36) | 0.1030 |
 Obese BMI | 114(3.34) | 57(5.32) | 1.61(1.23-2.11) | 0.0005 | 1.36(1.04-1.79) | 0.0261 | 134(3.55) | 37(5.22) | 1.56(1.11-2.18) | 0.0099 | 1.36(0.97-1.90) | 0.0747 |