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Table 3 Cox’s proportional hazard regression model for overall survival (OS) and breast cancer specific survival (BCSS) among breast cancer subtypes

From: Relationship between body mass index and the expression of hormone receptors or human epidermal growth factor receptor 2 with respect to breast cancer survival

Subtype Overall survival Breast cancer specific survival
  Alive Death HR (95 % CI) p value Adjust HR (95 % CI) p value Alive Death HR (95 % CI) p value Adjust HR (95 % CI) p value
ER and/or PR + and HER 2 -             
 No. of participants 19674 1420      20248 846     
 Underweight BMI 659(3.35) 47(3.31) 1.17(0.87-1.57) 0.2902 1.26(0.94-1.69) 0.1269 678(3.35) 28(3.31) 1.17(0.80-1.71) 0.4239 1.24(0.85-1.82) 0.2684
 Normal BMI 13352(67.87) 827(58.24) 1.00   1.00   13686(67.59) 493(58.27) 1.00   1.00  
 Overweight BMI 4901(24.91) 462(32.54) 1.48(1.32-1.66) <0.0001 1.32(1.18-1.48) <0.0001 5084(25.11) 279(32.98) 1.49(1.29-1.73) 0.0035 1.30(0.96-1.76) 0.0874
 Obese BMI 762(3.87) 84(5.92) 1.74(1.39-2.18) <0.0001 1.48(1.18-1.85) 0.0006 800(3.95) 46(5.44) 1.57(1.16-2.12) <0.0001 1.31(1.13-1.52) 0.0003
ER and/or PR + and HER 2 +             
 No. of participants 3691 427      3851 267     
 Underweight BMI 130(3.52) 14(3.28) 0.95(0.56-1.62) 0.8463 1.07(0.63-1.83) 0.802 139(3.61) 5(1.87) 0.54(0.22-1.31) 0.1737 0.61(0.25-1.48) 0.2705
 Normal BMI 2612(70.77) 297(69.56) 1.00   1.00   2726(70.79) 183(68.54) 1.00   1.00  
 Overweight BMI 827(22.41) 102(23.89) 1.06(0.85-1.33) 0.5960 1.02(0.81-1.28) 0.875 856(22.23) 73(27.34) 1.24(0.95-1.63) 0.1177 1.18(0.90-1.55) 0.2251
 Obese BMI 122(3.31) 14(3.28) 1.05(0.61-1.79) 0.8608 0.94(0.55-1.61) 0.8193 130(3.38) 6(2.25) 0.72(0.32-1.62) 0.4277 0.62(0.27-1.39) 0.2449
ER and PR - and HER 2 +             
 No. of participants 3349 538      3551 336     
 Underweight BMI 94(2.81) 27(5.02) 1.79(1.21-2.65) 0.0034 1.67(1.12-2.47) 0.0113 103(2.90) 18(5.36) 1.88(1.16-3.05) 0.0099 1.79(1.11-2.90) 0.0179
 Normal BMI 2288(68.32) 344(63.94) 1.00   1.00   2418(68.09) 214(63.69) 1.00   1.00  
 Overweight BMI 847(25.29) 141(26.21) 1.09(0.90-1.33) 0.3926 0.94(0.77-1.14) 0.5093 900(25.34) 88(26.19) 1.09(0.85-1.40) 0.4921 0.93(0.73-1.19) 0.5715
 Obese BMI 120(3.58) 26(4.83) 1.38(0.93-2.06) 0.1132 1.18(0.79-1.76) 0.4247 130(3.66) 16(4.76) 1.35(0.81-2.24) 0.2496 1.16(0.70-1.93) 0.5683
ER and PR - and HER 2 -             
 No. of participants 6424 1012      6770 666     
 Underweight BMI 215(3.35) 34(3.36) 1.09(0.77-1.54) 0.6222 1.19(0.84-1.68) 0.3333 225(3.32) 24(3.60) 1.14(0.76-1.72) 0.5347 1.27(0.84-1.92) 0.2606
 Normal BMI 4206(65.47) 610(60.28) 1.00   1.00   4402(65.02) 414(62.16) 1.00   1.00  
 Overweight BMI 1727(26.88) 311(30.73) 1.20(1.05-1.38) 0.0080 1.07(0.93-1.23) 0.3301 1849(27.31) 189(28.38) 1.07(0.90-1.27) 0.4398 0.93(0.79-1.11) 0.4320
 Obese BMI 276(4.30) 57(5.63) 1.37(1.04-1.80) 0.0234 1.18(0.90-1.55) 0.2395 294(4.34) 39(5.86) 1.38(0.99-1.91) 0.0571 1.16(0.84-1.61) 0.3749
Unknown             
 No. of participants 3415 1071      3777 709     
 Underweight BMI 131(3.84) 36(3.36) 0.98(0.70-1.37) 0.8923 1.11(0.79-1.55) 0.5528 139(3.68) 28(3.95) 1.16(0.79-1.70) 0.44 1.29(0.87-1.89) 0.2010
 Normal BMI 2308(67.58) 675(63.03) 1.00   1.00   2542(67.30) 441(62.20) 1.00   1.00  
 Overweight BMI 862(25.24) 303(28.29) 1.18(1.03-1.35) 0.0153 1.12(0.98-1.28) 0.1042 962(25.47) 203(28.63) 1.20(1.02-1.42) 0.0283 1.15(0.97-1.36) 0.1030
 Obese BMI 114(3.34) 57(5.32) 1.61(1.23-2.11) 0.0005 1.36(1.04-1.79) 0.0261 134(3.55) 37(5.22) 1.56(1.11-2.18) 0.0099 1.36(0.97-1.90) 0.0747
  1. Abbreviations: OS overall survival, BCSS breast cancer specific survival, HR hazard ratio
  2. Data presented as n (%) and HR (95 % CI)
  3. HRs are unadjusted or adjusted based on Cox’s proportional-hazard regression models
  4. Patient age; tumor size; histologic grade; lymph node status; operation method; adjuvant treatment; ER/PR status and HER2 expression included in the multivariate analysis model