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Fig. 2 | BMC Cancer

Fig. 2

From: High basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition in mammary carcinoma cell lines with HER2/3 overexpression

Fig. 2

Effects of drugs on cell viability. Cell viability (MTT assay) was measured after treatment with PI3K/mTor inhibitor BEZ235, mTor inhibitor Everolimus and cSRC inhibitor Src-l1. Three cell lines with a high TOP/FOP ratio (>30) (CMT1, CMT-U27, and CMT9) and CIPm cells with a low TOP/FOP ratio (<2) were grown for 40 h in the presence of PI3K/mTor inhibitor BEZ235 (50nM), mTor inhibitor Everolimus (100nM) and cSRC inhibitor Src-l1 (20 μM). After 40 h the cell numbers were measured with a MTT assay. Results expressed as % of control are the mean (±STDEV) of three independent experiments. *P < 0.01 versus appropriate cell line control (DMSO)

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BMC Cancer

ISSN: 1471-2407

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