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Table 2 Univariate logistic regression analysis showing associations of histopathological features in non-metastatic (N0/M0) versus lymphogenous-metastatic (N+) and haematogenous-metastatic (M+) CC

From: Histopathological features predict metastatic potential in locally advanced colon carcinomas

  N0/M0 vs. N+   N0/M0 vs. M+  
  OR (95% C.I.) p-value OR (95% C.I.) p-value
Tumor budding low vs. high 6.98 (1.88-25.92) 0.004 7.61 (2.07-27.97) 0.002
Inflammation zone 1 lymphocytic vs. non-lymphocytic 0.22 (0.04-1.23) 0.084 0.18 (0.03-0.99) 0.048
Inflammation zone 2 lymphocytic vs. non-lymphocytic 0.63 (0.08-4.83) NS 0.42 (0.06-2.71) NS
Tumor percentage distribution 0.99 (0.96-1.03) NS 0.98 (0.94-1.02) NS
Desmoplasia percentage distribution 1.02 (0.98-1.06) NS 1.01 (0.97-1.04) NS
Necrosis percentage distribution 0.98 (0.93-1.02) NS 1.01 (0.97-1.05) NS
Tumor/desmoplasia ratio (> median, ≤median) 0.34 (0.12-0.99) 0.049 0.63 (0.23-1.75) NS
Tumor/necrosis ratio (> median, ≤median) 0.68 (0.24-1.92) NS 0.38 (0.13-1.09) 0.073
Desmoplasia pattern finger-like vs. non-finger-like 0.31 (0.09-1.01) 0.051 0.66 (0.23-1.87) NS
Large vessel density zone 1 (> median, ≤median) 1.89 (0.63-5.62) NS 2.07 (0.71-6.06) NS
Large vessel density zone 2 (> median, ≤median) 2.61 (0.89-7.69) NS 0,92 (0.33-2.57) NS
Large vessel density zone 3 (> median, ≤median) 3.11 (1.03-9.32) 0.043 1.47 (0.53-4.09) NS
Small vessel density zone 1 (> median, ≤median) 0.79 (0.28-2.28) NS 0.24 (0.07-0.74) 0.013
Small vessel density zone 2 (> median, ≤median) 0.58 (0.20-1.65) NS 0.87 (0.31-2.42) NS
Small vessel density zone 3 (> median, ≤median) 1.30 (0.46-3.64) NS 1.20 (0.43-3.33) NS
Microvascular vessel density zone 1 (> median, ≤median) 0.89 (0.32-2.51) NS 0.87 (0.31-2.42) NS
Microvascular vessel density zone 2 (> median, ≤median) 1.37 (0.49-3.84) NS 0.52 (0.81-1.45) NS
Altered vessels zone 1 present vs. absent 0.83 (0.28-2.45) NS 0.93 (0.33-2.67) NS
Altered vessels zone 2 present vs. absent 1.41 (0.48-4.18) NS 1.12 (0.37-3.35) NS
Altered vessels zone 3 present vs. absent 0.93 (0.32-2.76) NS 0.74 (0.24-2.21) NS
Lymphatic vessels zone 1 open vs. compressed 0.29 (0.03-3.32) NS 0.59 (0.03-10.11) NS
Lymphatic vessels zone 2 open vs. compressed 1.59 (0.26-9.56) NS 1.22 (0.27-5.52) NS
Lymphatic vessels zone 3 open vs. compressed 1.62 (0.26-10.08) NS 1.77 (0.32-9.71) NS
  1. Relevant variables being significant (p < 0.05) or showing a strong tendency towards significance (p < 0.1).
  2. OR: odds ratio, C.I.: confidence interval, NS: no significant.