Table 2 Univariate logistic regression analysis showing associations of histopathological features in non-metastatic (N0/M0) versus lymphogenous-metastatic (N+) and haematogenous-metastatic (M+) CC
From: Histopathological features predict metastatic potential in locally advanced colon carcinomas
| Â | N0/M0 vs. N+ | Â | N0/M0 vs. M+ | Â |
|---|---|---|---|---|
| Â | OR (95% C.I.) | p-value | OR (95% C.I.) | p-value |
Tumor budding low vs. high | 6.98 (1.88-25.92) | 0.004 | 7.61 (2.07-27.97) | 0.002 |
Inflammation zone 1 lymphocytic vs. non-lymphocytic | 0.22 (0.04-1.23) | 0.084 | 0.18 (0.03-0.99) | 0.048 |
Inflammation zone 2 lymphocytic vs. non-lymphocytic | 0.63 (0.08-4.83) | NS | 0.42 (0.06-2.71) | NS |
Tumor percentage distribution | 0.99 (0.96-1.03) | NS | 0.98 (0.94-1.02) | NS |
Desmoplasia percentage distribution | 1.02 (0.98-1.06) | NS | 1.01 (0.97-1.04) | NS |
Necrosis percentage distribution | 0.98 (0.93-1.02) | NS | 1.01 (0.97-1.05) | NS |
Tumor/desmoplasia ratio (> median, ≤median) | 0.34 (0.12-0.99) | 0.049 | 0.63 (0.23-1.75) | NS |
Tumor/necrosis ratio (> median, ≤median) | 0.68 (0.24-1.92) | NS | 0.38 (0.13-1.09) | 0.073 |
Desmoplasia pattern finger-like vs. non-finger-like | 0.31 (0.09-1.01) | 0.051 | 0.66 (0.23-1.87) | NS |
Large vessel density zone 1 (> median, ≤median) | 1.89 (0.63-5.62) | NS | 2.07 (0.71-6.06) | NS |
Large vessel density zone 2 (> median, ≤median) | 2.61 (0.89-7.69) | NS | 0,92 (0.33-2.57) | NS |
Large vessel density zone 3 (> median, ≤median) | 3.11 (1.03-9.32) | 0.043 | 1.47 (0.53-4.09) | NS |
Small vessel density zone 1 (> median, ≤median) | 0.79 (0.28-2.28) | NS | 0.24 (0.07-0.74) | 0.013 |
Small vessel density zone 2 (> median, ≤median) | 0.58 (0.20-1.65) | NS | 0.87 (0.31-2.42) | NS |
Small vessel density zone 3 (> median, ≤median) | 1.30 (0.46-3.64) | NS | 1.20 (0.43-3.33) | NS |
Microvascular vessel density zone 1 (> median, ≤median) | 0.89 (0.32-2.51) | NS | 0.87 (0.31-2.42) | NS |
Microvascular vessel density zone 2 (> median, ≤median) | 1.37 (0.49-3.84) | NS | 0.52 (0.81-1.45) | NS |
Altered vessels zone 1 present vs. absent | 0.83 (0.28-2.45) | NS | 0.93 (0.33-2.67) | NS |
Altered vessels zone 2 present vs. absent | 1.41 (0.48-4.18) | NS | 1.12 (0.37-3.35) | NS |
Altered vessels zone 3 present vs. absent | 0.93 (0.32-2.76) | NS | 0.74 (0.24-2.21) | NS |
Lymphatic vessels zone 1 open vs. compressed | 0.29 (0.03-3.32) | NS | 0.59 (0.03-10.11) | NS |
Lymphatic vessels zone 2 open vs. compressed | 1.59 (0.26-9.56) | NS | 1.22 (0.27-5.52) | NS |
Lymphatic vessels zone 3 open vs. compressed | 1.62 (0.26-10.08) | NS | 1.77 (0.32-9.71) | NS |