Miettinen M, Lasota J: Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch. 2001, 438 (1): 1-12. 10.1007/s004280000338.
Article
CAS
PubMed
Google Scholar
Kindblom LG, Remotti HE, Aldenborg F, Meis-Kindblom JM: Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol. 1998, 152 (5): 1259-1269.
CAS
PubMed
PubMed Central
Google Scholar
Rutkowski P, Debiec-Rychter M, Ruka W: Gastrointestinal stromal tumors: key to diagnosis and choice of therapy. Mol Diagn Ther. 2008, 12 (3): 131-143.
Article
CAS
PubMed
Google Scholar
Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, et al: Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998, 279 (5350): 577-580. 10.1126/science.279.5350.577.
Article
CAS
PubMed
Google Scholar
Corless CL, Fletcher JA, Heinrich MC: Biology of gastrointestinal stromal tumors. J Clin Oncol. 2004, 22 (18): 3813-3825. 10.1200/JCO.2004.05.140.
Article
CAS
PubMed
Google Scholar
Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita K, Shinomura Y, Kitamura Y: Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors. Gastroenterology. 2003, 125 (3): 660-667. 10.1016/S0016-5085(03)01046-1.
Article
CAS
PubMed
Google Scholar
Ihle JN, Kerr IM: Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet. 1995, 11 (2): 69-74. 10.1016/S0168-9525(00)89000-9.
Article
CAS
PubMed
Google Scholar
Schindler C, Darnell JE: Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem. 1995, 64: 621-651. 10.1146/annurev.bi.64.070195.003201.
Article
CAS
PubMed
Google Scholar
Weiler SR, Mou S, DeBerry CS, Keller JR, Ruscetti FW, Ferris DK, Longo DL, Linnekin D: JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor. Blood. 1996, 87 (9): 3688-3693.
CAS
PubMed
Google Scholar
Brizzi MF, Dentelli P, Rosso A, Yarden Y, Pegoraro L: STAT protein recruitment and activation in c-Kit deletion mutants. J Biol Chem. 1999, 274 (24): 16965-16972. 10.1074/jbc.274.24.16965.
Article
CAS
PubMed
Google Scholar
Mui AL: The role of STATs in proliferation, differentiation, and apoptosis. Cell Mol Life Sci. 1999, 55 (12): 1547-1558. 10.1007/s000180050394.
Article
CAS
PubMed
Google Scholar
Porfiri E, McCormick F: Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSOS1. J Biol Chem. 1996, 271 (10): 5871-5877. 10.1074/jbc.271.10.5871.
Article
CAS
PubMed
Google Scholar
Burack WR, Sturgill TW: The activating dual phosphorylation of MAPK by MEK is nonprocessive. Biochemistry. 1997, 36 (20): 5929-5933. 10.1021/bi970535d.
Article
CAS
PubMed
Google Scholar
Zhang C, Schmidt M, von Eichei-Streiber C, Jakobs KH: Inhibition by toxin B of inositol phosphate formation induced by G protein-coupled and tyrosine kinase receptors in N1E-115 neuroblastoma cells: involvement of Rho proteins. Mol Pharmacol. 1996, 50 (4): 864-869.
CAS
PubMed
Google Scholar
Barker SA, Caldwell KK, Pfeiffer JR, Wilson BS: Wortmannin-sensitive phosphorylation, translocation, and activation of PLCgamma1, but not PLCgamma2, in antigen-stimulated RBL-2H3 mast cells. Mol Biol Cell. 1998, 9 (2): 483-496.
Article
CAS
PubMed
PubMed Central
Google Scholar
Timokhina I, Kissel H, Stella G, Besmer P: Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation. Embo J. 1998, 17 (21): 6250-6262. 10.1093/emboj/17.21.6250.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schlessinger J: Cell signaling by receptor tyrosine kinases. Cell. 2000, 103 (2): 211-225. 10.1016/S0092-8674(00)00114-8.
Article
CAS
PubMed
Google Scholar
Kang HJ, Nam SW, Kim H, Rhee H, Kim NG, Kim H, Hyung WJ, Noh SH, Kim JH, Yun CO, et al: Correlation of KIT and platelet-derived growth factor receptor alpha mutations with gene activation and expression profiles in gastrointestinal stromal tumors. Oncogene. 2005, 24 (6): 1066-1074. 10.1038/sj.onc.1208358.
Article
CAS
PubMed
Google Scholar
Subramanian S, West RB, Corless CL, Ou W, Rubin BP, Chu KM, Leung SY, Yuen ST, Zhu S, Hernandez-Boussard T, et al: Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles. Oncogene. 2004, 23 (47): 7780-7790. 10.1038/sj.onc.1208056.
Article
CAS
PubMed
Google Scholar
Kang HJ, Koh KH, Yang E, You KT, Kim HJ, Paik YK, Kim H: Differentially expressed proteins in gastrointestinal stromal tumors with KIT and PDGFRA mutations. Proteomics. 2006, 6 (4): 1151-1157. 10.1002/pmic.200500372.
Article
CAS
PubMed
Google Scholar
Lasota J, Miettinen M: KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs). Semin Diagn Pathol. 2006, 23 (2): 91-102. 10.1053/j.semdp.2006.08.006.
Article
PubMed
Google Scholar
Tran T, Davila JA, El-Serag HB: The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000. Am J Gastroenterol. 2005, 100 (1): 162-168. 10.1111/j.1572-0241.2005.40709.x.
Article
PubMed
Google Scholar
Perez EA, Livingstone AS, Franceschi D, Rocha-Lima C, Lee DJ, Hodgson N, Jorda M, Koniaris LG: Current incidence and outcomes of gastrointestinal mesenchymal tumors including gastrointestinal stromal tumors. J Am Coll Surg. 2006, 202 (4): 623-629. 10.1016/j.jamcollsurg.2006.01.002.
Article
PubMed
Google Scholar
Lasota J, vel Dobosz AJ, Wasag B, Wozniak A, Kraszewska E, Michej W, Ptaszynski K, Rutkowski P, Sarlomo-Rikala M, Steigen SE, et al: Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors. Lab Invest. 2007, 87 (10): 1029-1041. 10.1038/labinvest.3700628.
Article
CAS
PubMed
Google Scholar
Rutkowski P, Debiec-Rychter M, Nowecki ZI, Wozniak A, Michej W, Limon J, Siedlecki JA, Jerzak Vel Dobosz A, Grzesiakowska U, Nasierowska-Guttmejer A, et al: Different factors are responsible for predicting relapses after primary tumors resection and for imatinib treatment outcomes in gastrointestinal stromal tumors. Med Sci Monit. 2007, 13 (11): CR515-522.
CAS
PubMed
Google Scholar
Ostrowski J, Mikula M, Karczmarski J, Rubel T, Wyrwicz LS, Bragoszewski P, Gaj P, Dadlez M, Butruk E, Regula J: Molecular defense mechanisms of Barrett's metaplasia estimated by an integrative genomics. J Mol Med. 2007, 85 (7): 733-743. 10.1007/s00109-007-0176-3.
Article
CAS
PubMed
Google Scholar
Stark C, Breitkreutz BJ, Reguly T, Boucher L, Breitkreutz A, Tyers M: BioGRID: a general repository for interaction datasets. Nucleic Acids Res. 2006, D535-539. 10.1093/nar/gkj109. 34 Database
Peri S, Navarro JD, Kristiansen TZ, Amanchy R, Surendranath V, Muthusamy B, Gandhi TK, Chandrika KN, Deshpande N, Suresh S, et al: Human protein reference database as a discovery resource for proteomics. Nucleic Acids Res. 2004, D497-501. 10.1093/nar/gkh070. 32 Database
Gilbert D: Biomolecular interaction network database. Brief Bioinform. 2005, 6 (2): 194-198. 10.1093/bib/6.2.194.
Article
CAS
PubMed
Google Scholar
Besmer P, Murphy JE, George PC, Qiu FH, Bergold PJ, Lederman L, Snyder HW, Brodeur D, Zuckerman EE, Hardy WD: A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature. 1986, 320 (6061): 415-421. 10.1038/320415a0.
Article
CAS
PubMed
Google Scholar
Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A: Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. Embo J. 1987, 6 (11): 3341-3351.
CAS
PubMed
PubMed Central
Google Scholar
Besmer P: The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor. Curr Opin Cell Biol. 1991, 3 (6): 939-946. 10.1016/0955-0674(91)90111-B.
Article
CAS
PubMed
Google Scholar
Sanders KM, Ordog T, Koh SD, Torihashi S, Ward SM: Development and plasticity of interstitial cells of Cajal. Neurogastroenterol Motil. 1999, 11 (5): 311-338. 10.1046/j.1365-2982.1999.00164.x.
Article
CAS
PubMed
Google Scholar
Nocka K, Majumder S, Chabot B, Ray P, Cervone M, Bernstein A, Besmer P: Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice. Genes Dev. 1989, 3 (6): 816-826. 10.1101/gad.3.6.816.
Article
CAS
PubMed
Google Scholar
Rousset D, Agnes F, Lachaume P, Andre C, Galibert F: Molecular evolution of the genes encoding receptor tyrosine kinase with immunoglobulinlike domains. J Mol Evol. 1995, 41 (4): 421-429. 10.1007/BF00160313.
Article
CAS
PubMed
Google Scholar
Salto-Tellez M, Nga ME, Han HC, Wong AS, Lee CK, Anuar D, Ng SS, Ho M, Wee A, Chan YH, et al: Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours. Br J Cancer. 2007, 96 (5): 776-782. 10.1038/sj.bjc.6603551.
Article
CAS
PubMed
PubMed Central
Google Scholar
McAuliffe JC, Lazar AJ, Yang D, Steinert DM, Qiao W, Thall PF, Raymond AK, Benjamin RS, Trent JC: Association of intratumoral vascular endothelial growth factor expression and clinical outcome for patients with gastrointestinal stromal tumors treated with imatinib mesylate. Clin Cancer Res. 2007, 13 (22 Pt 1): 6727-6734. 10.1158/1078-0432.CCR-07-0895.
Article
CAS
PubMed
Google Scholar
Reyland ME: Protein kinase C isoforms: Multi-functional regulators of cell life and death. Front Biosci. 2009, 14: 2386-2399. 10.2741/3385.
Article
CAS
Google Scholar
Martiny-Baron G, Fabbro D: Classical PKC isoforms in cancer. Pharmacol Res. 2007, 55 (6): 477-486. 10.1016/j.phrs.2007.04.001.
Article
CAS
PubMed
Google Scholar
Gutcher I, Webb PR, Anderson NG: The isoform-specific regulation of apoptosis by protein kinase C. Cell Mol Life Sci. 2003, 60 (6): 1061-1070.
CAS
PubMed
Google Scholar
Lee HE, Kim MA, Lee HS, Lee BL, Kim WH: Characteristics of KIT-negative gastrointestinal stromal tumours and diagnostic utility of protein kinase C theta immunostaining. J Clin Pathol. 2008, 61 (6): 722-729. 10.1136/jcp.2007.052225.
Article
CAS
PubMed
Google Scholar