Role of key-regulator genes in melanoma susceptibility and pathogenesis among patients from South Italy

BMC Cancer

Table 6 Genetic and functional alterations in candidate genes among in vitro melanoma cell lines

Cell line derived from	ERK1	ERK2	pERK	p16	BRAF	NRAS	p16^CDKN2A
Primary melanoma
GR-Mel	+++	++	+	++
LCP-Mel	+++	+++	++	+	V600R		Del exon 2
MNG	+++	+++	++/+++	+
PNP-Mel	+++	+++	++	+	V600E		G101W
ST-Mel	++/+++	+++	+++	++	G466E
Metastatic lymph node
CN-Mel	+++	+++	++	+		Q61R
CR-Mel	+++	+++	++	+		Q61K	Del exon 2
GL-Mel	+++	+++	++	+			Del exon 2
LCM-Mel	+++	++	++	-	V600R		Del exons 1-2
MAR	+++	+/++	+	+
SK-Mel-28	+++	++	++	+++	V600E
13443-Mel	+++	++	+	+++
Cutaneous metastasis
LB-24-Mel	+++	+++	+++	++
M14	+++	+++	++	+	V600E		455insCdel26 IVS1+2T>C
PR-Mel	+++	+++	+	++	V600R
SN-Mel	++	++/+++	+	++	V600E
WM-266-4	+++	++	++/+++	-	V600D		Del exon 1
397-Mel	++	++	++	+			Del exon 2

ISSN: 1471-2407