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Table 6 Genetic and functional alterations in candidate genes among in vitro melanoma cell lines

From: Role of key-regulator genes in melanoma susceptibility and pathogenesis among patients from South Italy

Cell line
derived from
ERK1 ERK2 pERK p16 BRAF NRAS p16CDKN2A
Primary melanoma        
GR-Mel +++ ++ + ++    
LCP-Mel +++ +++ ++ + V600R   Del exon 2
MNG +++ +++ ++/+++ +    
PNP-Mel +++ +++ ++ + V600E   G101W
ST-Mel ++/+++ +++ +++ ++ G466E   
Metastatic lymph node        
CN-Mel +++ +++ ++ +   Q61R  
CR-Mel +++ +++ ++ +   Q61K Del exon 2
GL-Mel +++ +++ ++ +    Del exon 2
LCM-Mel +++ ++ ++ - V600R   Del exons 1-2
MAR +++ +/++ + +    
SK-Mel-28 +++ ++ ++ +++ V600E   
13443-Mel +++ ++ + +++    
Cutaneous metastasis        
LB-24-Mel +++ +++ +++ ++    
M14 +++ +++ ++ + V600E   455insCdel26 IVS1+2T>C
PR-Mel +++ +++ + ++ V600R   
SN-Mel ++ ++/+++ + ++ V600E   
WM-266-4 +++ ++ ++/+++ - V600D   Del exon 1
397-Mel ++ ++ ++ +    Del exon 2