Figure 1
From: A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine
Characterisation of p53 expression levels in induced Cre+Apc fl/fl p53 +/+ intestinal samples. a) p53 IHC was performed 4 days post Apc loss and shows that p53 is only up-regulated in a subset of cells, towards the leading edge but within the aberrant structure seen following Apc loss. b) QRT-PCR expression analysis of intestinal samples 4 days post Apc loss (ApcFlox) confirms that p53 transcript is up-regulated approximately 2 fold.