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Table 1 TBARS plasma lipid peroxidation levels following oxidative stresses

From: Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model

 

Absorbance values (Arbitrary scale)

 

Air Control (AC)

Acute Hypoxia (AH)

Ratio (AH/AC)

MDA treatment

Expt 1 (n = 4–5)

0.080+/-0.005

0.101+/-0.007

1.27

0.519+/-0.066

Expt 2 (n = 7)

0.132+/-0.006

0.152+/-0.008

1.16

 

Expt 3 (n = 8–9)

0.048+/-0.002

0.060+/-0.004

1.24

 
  1. Lipid peroxidation assessed by TBARS assay in plasma of transgenic mice treated with 6 weeks of acute hypoxia (AH) showed a significantly increased plasma absorbance levels relative to air control (AC) conditions in 3 repeat assays (mixed modelling analysis on combined data; P < 0.0005). Lipid peroxidation in plasma of positive control WT animals drinking MDA-supplemented acidified water for 6 weeks was significantly increased relative to both AH – (P < 0.01) and AC – (P < 0.001) exposed mice. Mean+/- SEM are shown for each experimental group.
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BMC Cancer

ISSN: 1471-2407

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