Clinical and pathologic factors associated with development of hepatocellular carcinoma in patients with hepatitis virus-related cirrhosis: a long-term follow-up study
© Rosas-Camargo et al; licensee BioMed Central Ltd. 2007
Published: 5 February 2007
Hepatocellular carcinoma (HCC) represents >90% of primary liver neoplasms and develops mainly in patients with liver cirrhosis. Risk factor identification for development of HCC in patients with cirrhosis possesses great clinical relevance due to its high incidence and poor prognosis when detected at advanced stages. The aim of our study was to identify HCC development-associated risk factors in a cohort of patients with hepatitis virus-related chronic liver disease and cirrhosis.
Materials and methods
Patients with a diagnosis of hepatitis virus-related cirrhosis from January 1980 to January 2000 were included. Patients were followed with abdominal ultrasound and determination of alpha-fetoprotein levels, physical examination, and routine biochemical tests every 3–6 months. The endpoint in this study was defined as development of HCC. Liver histology was evaluated according to the French METAVIR Cooperative Study Group (METAVIR) score.
Variables with independent predictive value for HCC in the multivariate analysis
Hazard ratio (95% confidence interval)
P value (log rank)
We found three HCC-associated variables: histological activity; platelet count and alpha-fetoprotein levels. Patients with high risk for developing hepatocellular carcinoma must be considered candidates for closer follow-up.
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