Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, Thun MJ: Cancer statistics, 2006. CA Cancer J Clin. 2006, 56 (2): 106-130.
Article
PubMed
Google Scholar
Shipman CM, Rogers MJ, Apperley JF, Russell RG, Croucher PI: Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity. Br J Haematol. 1997, 98 (3): 665-672. 10.1046/j.1365-2141.1997.2713086.x.
Article
CAS
PubMed
Google Scholar
Shipman CM, Croucher PI, Russell RG, Helfrich MH, Rogers MJ: The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. Cancer Res. 1998, 58 (23): 5294-5297.
CAS
PubMed
Google Scholar
Aparicio A, Gardner A, Tu Y, Savage A, Berenson J, Lichtenstein A: In vitro cytoreductive effects on multiple myeloma cells induced by bisphosphonates. Leukemia. 1998, 12 (2): 220-229. 10.1038/sj.leu.2400892.
Article
CAS
PubMed
Google Scholar
Derenne S, Amiot M, Barille S, Collette M, Robillard N, Berthaud P, Harousseau JL, Bataille R: Zoledronate is a potent inhibitor of myeloma cell growth and secretion of IL-6 and MMP-1 by the tumoral environment. J Bone Miner Res. 1999, 14 (12): 2048-2056. 10.1359/jbmr.1999.14.12.2048.
Article
CAS
PubMed
Google Scholar
Tassone P, Forciniti S, Galea E, Morrone G, Turco MC, Martinelli V, Tagliaferri P, Venuta S: Growth inhibition and synergistic induction of apoptosis by zoledronate and dexamethasone in human myeloma cell lines. Leukemia. 2000, 14 (5): 841-844. 10.1038/sj.leu.2401770.
Article
CAS
PubMed
Google Scholar
Takahashi R, Shimazaki C, Inaba T, Okano A, Hatsuse M, Okamoto A, Hirai H, Ashihara E, Nakagawa M: A newly developed bisphosphonate, YM529, is a potent apoptosis inducer of human myeloma cells. Leuk Res. 2001, 25 (1): 77-83. 10.1016/S0145-2126(00)00087-4.
Article
CAS
PubMed
Google Scholar
Giuliani N, Pedrazzoni M, Passeri G, Girasole G: Bisphosphonates inhibit IL-6 production by human osteoblast-like cells. Scand J Rheumatol. 1998, 27 (1): 38-41. 10.1080/030097498441155.
Article
CAS
PubMed
Google Scholar
Senaratne SG, Pirianov G, Mansi JL, Arnett TR, Colston KW: Bisphosphonates induce apoptosis in human breast cancer cell lines. Br J Cancer. 2000, 82 (8): 1459-1468.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lee MV, Fong EM, Singer FR, Guenette RS: Bisphosphonate treatment inhibits the growth of prostate cancer cells. Cancer Res. 2001, 61 (6): 2602-2608.
CAS
PubMed
Google Scholar
Fromigue O, Lagneaux L, Body JJ: Bisphosphonates induce breast cancer cell death in vitro. J Bone Miner Res. 2000, 15 (11): 2211-2221. 10.1359/jbmr.2000.15.11.2211.
Article
CAS
PubMed
Google Scholar
Jagdev SP, Coleman RE, Shipman CM, Rostami HA, Croucher PI: The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel. Br J Cancer. 2001, 84 (8): 1126-1134. 10.1054/bjoc.2001.1727.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tassone P, Tagliaferri P, Viscomi C, Palmieri C, Caraglia M, D'Alessandro A, Galea E, Goel A, Abbruzzese A, Boland CR, Venuta S: Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. Br J Cancer. 2003, 88 (12): 1971-1978. 10.1038/sj.bjc.6600986.
Article
CAS
PubMed
PubMed Central
Google Scholar
Widler L, Jaeggi KA, Glatt M, Muller K, Bachmann R, Bisping M, Born AR, Cortesi R, Guiglia G, Jeker H, Klein R, Ramseier U, Schmid J, Schreiber G, Seltenmeyer Y, Green JR: Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa). J Med Chem. 2002, 45 (17): 3721-3738. 10.1021/jm020819i.
Article
CAS
PubMed
Google Scholar
Suri S, Monkkonen J, Taskinen M, Pesonen J, Blank MA, Phipps RJ, Rogers MJ: Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. Bone. 2001, 29 (4): 336-343. 10.1016/S8756-3282(01)00589-0.
Article
CAS
PubMed
Google Scholar
Chen T, Berenson J, Vescio R, Swift R, Gilchick A, Goodin S, LoRusso P, Ma P, Ravera C, Deckert F, Schran H, Seaman J, Skerjanec A: Pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with bone metastases. J Clin Pharmacol. 2002, 42 (11): 1228-1236. 10.1177/009127002762491316.
Article
CAS
PubMed
Google Scholar
Sato M, Grasser W, Endo N, Akins R, Simmons H, Thompson DD, Golub E, Rodan GA: Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest. 1991, 88 (6): 2095-2105.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cui N, Nomura T, Noma H, Yokoo K, Takagi R, Hashimoto S, Okamoto M, Sato M, Yu G, Guo C, Shibahala T: Effect of YM529 on a model of mandibular invasion by oral squamous cell carcinoma in mice. Clin Cancer Res. 2005, 11 (7): 2713-2719. 10.1158/1078-0432.CCR-04-1767.
Article
CAS
PubMed
Google Scholar
Segawa H, Kimura S, Kuroda J, Sato K, Nogawa M, Yuasa T, Yokota A, Hodohara K, Fujiyama Y, Maekawa T: The anti-leukemic efficacy of the third generation bisphosphonate ONO5920/YM529. Leuk Res. 2005, 29 (4): 451-457. 10.1016/j.leukres.2004.10.004.
Article
CAS
PubMed
Google Scholar
Yuasa T, Nogawa M, Kimura S, Yokota A, Sato K, Segawa H, Kuroda J, Maekawa T: A third-generation bisphosphonate, minodronic acid (YM529), augments the interferon alpha/beta-mediated inhibition of renal cell cancer cell growth both in vitro and in vivo. Clin Cancer Res. 2005, 11 (2 Pt 1): 853-859.
CAS
PubMed
Google Scholar
Horie N, Murata H, Nishigaki Y, Matsui T, Segawa H, Nogawa M, Yuasa T, Kimura S, Maekawa T, Fushiki S, Kubo T: The third-generation bisphosphonates inhibit proliferation of murine osteosarcoma cells with induction of apoptosis. Cancer Lett. 2006, 238 (1): 111-118. 10.1016/j.canlet.2005.06.041.
Article
CAS
PubMed
Google Scholar
Matsumoto S, Kimura S, Segawa H, Kuroda J, Yuasa T, Sato K, Nogawa M, Tanaka F, Maekawa T, Wada H: Efficacy of the third-generation bisphosphonate, zoledronic acid alone and combined with anti-cancer agents against small cell lung cancer cell lines. Lung Cancer. 2005, 47 (1): 31-39. 10.1016/j.lungcan.2004.06.003.
Article
PubMed
Google Scholar
Tannehill-Gregg SH, Levine AL, Nadella MV, Iguchi H, Rosol TJ: The effect of zoledronic acid and osteoprotegerin on growth of human lung cancer in the tibias of nude mice. Clin Exp Metastasis. 2006, 23 (1): 19-31. 10.1007/s10585-006-9008-z.
Article
CAS
PubMed
Google Scholar
Herrmann BG, Frischauf AM: Isolation of genomic DNA. Methods Enzymol. 1987, 152: 180-183.
Article
CAS
PubMed
Google Scholar
Katz ME, McCormick F: Signal transduction from multiple Ras effectors. Curr Opin Genet Dev. 1997, 7 (1): 75-79. 10.1016/S0959-437X(97)80112-8.
Article
CAS
PubMed
Google Scholar
Bergstrom JD, Bostedor RG, Masarachia PJ, Reszka AA, Rodan G: Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys. 2000, 373 (1): 231-241. 10.1006/abbi.1999.1502.
Article
CAS
PubMed
Google Scholar
van Beek E, Pieterman E, Cohen L, Lowik C, Papapoulos S: Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo. Biochem Biophys Res Commun. 1999, 255 (2): 491-494. 10.1006/bbrc.1999.0224.
Article
CAS
PubMed
Google Scholar
Neri A, Knowles DM, Greco A, McCormick F, Dalla-Favera R: Analysis of RAS oncogene mutations in human lymphoid malignancies. Proc Natl Acad Sci U S A. 1988, 85 (23): 9268-9272. 10.1073/pnas.85.23.9268.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH, Rogers MJ: Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther. 2001, 296 (2): 235-242.
CAS
PubMed
Google Scholar
Shintani S, Li C, Mihara M, Yano J, Terakado N, Nakashiro K, Hamakawa H: Gefitinib ('Iressa', ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, up-regulates p27KIP1 and induces G1 arrest in oral squamous cell carcinoma cell lines. Oral Oncol. 2004, 40 (1): 43-51. 10.1016/S1368-8375(03)00131-3.
Article
CAS
PubMed
Google Scholar
Di Gennaro E, Barbarino M, Bruzzese F, De Lorenzo S, Caraglia M, Abbruzzese A, Avallone A, Comella P, Caponigro F, Pepe S, Budillon A: Critical role of both p27KIP1 and p21CIP1/WAF1 in the antiproliferative effect of ZD1839 ('Iressa'), an epidermal growth factor receptor tyrosine kinase inhibitor, in head and neck squamous carcinoma cells. J Cell Physiol. 2003, 195 (1): 139-150. 10.1002/jcp.10239.
Article
CAS
PubMed
Google Scholar
Sun J, Blaskovich MA, Knowles D, Qian Y, Ohkanda J, Bailey RD, Hamilton AD, Sebti SM: Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. Cancer Res. 1999, 59 (19): 4919-4926.
CAS
PubMed
Google Scholar