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Prognosis of screen-detected breast cancers: results of a population based study
© Cortesi et al; licensee BioMed Central Ltd. 2006
Received: 25 July 2005
Accepted: 23 January 2006
Published: 23 January 2006
The reduced mortality rate from breast carcinoma among women offered screening mammography is demonstrated after 15–20 years of follow-up. However, the assessment of 5-year overall and event-free survival could represent an earlier measure of the efficacy of mammography screening program (MSP).
All cases of breast cancer diagnosed in the Province of Modena between years 1996 and 2000 in women aged 50 to 69 years, were identified through the Modena Cancer Registry (MCR). Stage of disease and treatment information were obtained from clinical records. All the events occurring up to June 30, 2003 were retrieved by experienced monitors. Five-year overall and event-free survival were the principal end-points of the study.
During a 5-year period, 587 primary breast cancers were detected by the MSP and 471 primary breast cancers were diagnosed out of the MSP. The screen-detected breast cancers were smaller, more likely node negative, with low histological grade, low proliferative activity and positive receptors status. Furthermore, the breast cancer diagnosed through the MSP more frequently received a conservative surgery. The 5-year survival rate was 94% in the screen-detected group, versus 84% in the other group (p = 0.0001). The rate of 5-year event-free survival was 89% and 75% for the MSP participants and not participants, respectively (p = 0.0001).
Our data confirm a favourable outcome of screen-detected breast cancers in terms of five-year overall and event-free survival, which reflect the good quality assurance parameters of the MSP. Finally, a cancer registry should be implemented in every area covered by screening programs.
Breast cancer is the most common malignancy in women, both in the developed and developing world, with annual incidence rates ranging from 11.8 per 100,000 in eastern China to 86.3 per 100,000 in North America. During recent decades the incidence of breast cancer has increased in Western Europe and the United States, while the mortality decreased[2, 3]. Part of the increase in incidence reflects the success of breast cancer screening programs. There is sufficient evidence from randomized trials that inviting women 50–69 years of age to be screened with mammography will eventually reduce their mortality from breast cancer. The first randomized clinical trial performed in New York during the 1960s evaluated the value of "early detection" by physical examination and mammography, while the Swedish trials, during the 1970s and 1980s (Malmo, Two-County, Stockholm and Goteborg) used only mammography to find out the independent value of this modality [6–9]. A recent review performed by a committee confirmed their previous results . Even another randomized trial in the United Kingdom (Edinburgh) gave the same results. Mammography screening reduces breast cancer mortality of invited women by 20% to 30% in comparison with controls. Mammography screening makes it possible to detect breast cancer at a subclinical or non-palpable stage. Early detection of such small tumours by screening shows a positive effect on survival because of overall decreased mortality from breast cancer [12–14]. Even after a follow-up period as long as 17 years the expected rate of mortality from breast cancer is reduced. In Modena, Italy, a population-based mammography screening for breast cancer was begun in 1995, providing a biennial screening to women aged 50 to 69 years. However, since the effect on breast cancer mortality will only become evident in the long term, monitoring the early outcomes seemed to us essential in the early phases for early evaluation of the efficacy of the screening program. In fact, several studies have shown that the interval from initial diagnosis to recurrence is a relevant prognostic factor [16, 17], since patients with early recurrence tend to do worse than those with late relapse .
In the current study we report the results of an exhaustive review of all breast cancers diagnosed between October 1995 and December 2000 in the Province of Modena, in women 50–69 years of age, assessing the rates of small tumors, the patterns of care and the relapse-free, event-free and 5 years survivals in women exposed to screening and in women diagnosed over the same time-interval out of screening.
In October, a population-based mammography screening program (MSP) began in the Province of Modena, one of the nine provinces of the Emilia-Romagna region (located in northern Italy). On december 1996, the population of Modena was 613,625, which by the end of 2000 had increased to 632,626, with a density of 235 inhab./sq.km. Out of this population, 80,210 were healthy women, aged 50–69 years. Briefly, all the asymptomatic female residents in the Province of Modena aged 50–69 years were invited to participate in a biannual bilateral two-view screening mammogram, with no direct financial charge to the participant. Women already affected by breast cancer were not invited. From 31st December, 1999 to 31st December, 2000, 48,928 women aged 50–69 years participated in the screening mammography, with an adhesion rate of 61.3%. Up to 31st December, 2000, 43,479 women adhered to the program (adhesion rate of 65.9%).
All the patients with an age ranging from 50 to 69 years diagnosed with breast cancer in the period 1996–2000 were selected from the Modena Cancer Registry (MCR), which has operated since 1988 and collects all new cases of cancers occurring in residents in the Province of Modena. A cross linkage between data from MSP and MCR allowed the identification of cases with invasive or in situ breast cancer diagnosed between 1st January, 1996 and 31st December, 2000 who did and did not the MSP. All breast cancer cases were identified as International Classification of Disease (9th revision) rubric 174. For every case, data on histology, staging at presentation (based on the 2003 UICC-TNM classification  and treatment were obtained from clinical records. All the events (local or distant recurrence, either second breast or non-breast tumours and deaths from breast cancer or from any other cause) that occurred among these women through during the follow-up were retrieved by experienced clinical documentation clerks with active follow-up strategies.
Overall survival was defined as the time from surgery until death from any cause, and cancer-free survival was defined as the time from surgery until the appearance of the first recurrence of cancer, a second cancer, or death from any cause. Survival was estimated by the Kaplan-Meier method, and any differences in survival were evaluated with a stratified log-rank test.
The Statistical Package for Social Sciences (version 10, SPSS®) was used for all calculations. Differences were considered to be statistically significant when the P value was 0.05 or less. All statistical tests were two-sided.
The Cox proportional hazards regression model was used in multivariate analysis, to determine whether the identified risk factors independently influenced survival rates. The co-variates selected were: modality of detection (screening vs. non screening), TNM stage (I vs others), chemotherapy (performed or not performed) and hormonal treatment (performed or not performed). Hazard ratios (HR) and 95% exact mid-P confidence intervals (CI) were calculated and the Wald method was used for the significance test.
Mean follow-up between the two groups and relative differences between patients at every stage
Distribution of those exposed to screening
Time of mean follow-up in thoxe exposed to screening (months)
Distribution in non screen-detected
Time of mean follow-up in non-screen-detected (months)
Differences between mean follow-up (months)
c i,s = x i,s - t s
where t s is the mean difference in follow-up time duration between the two groups at stage s, for i from 1 to N sd and for j from 1 to N nsd , x i,sd and x j,nsd are durations of follow-up for each woman at each stage in each group and N sd and N nsd are the population size of screen and not screen-detected groups. Then, the correct follow-up time (c i,s ) is obtained by subtracting the stage-specific difference from the follow-up time in the screen-detected group.
Proportion of cancers detected by the MSP
Prognostic factors' distribution among women exposed to screening and non-screen-detected invasive breast cancers
Exposed to screening n(%)
Tumour size (mm.)
Positive Nodal Status
Positive Hormonal Status
< 0.05 (0.02)
Concerning the characteristics of interval cancers, they had a mean size of 18 mm, the nodal status and the hormonal receptors were positive in 24% and 70% of cases, respectively, and the proliferative activity was high in 34% of tumours. Finally the tumours was poorly differentiated (GIII) in 45% of cases.
The median follow-up was 52 months in both groups, with a 25% of patients followed for more than 66 months. Survival data were evaluated only for invasive cancers, i.e. for 482 patients exposed to screening and 429 in the non-screen exposed group. Six (1%) and thirty-nine (9%) patients were lost at the follow-up in the study and control group, respectively. At time of last follow-up 22 women had died in the screen-detected (20 for breast cancer and 2 for other causes) and 60 in the non-screen-detected group (19 for breast cancer recurrences and 41 for others causes). The overall survival rates in the two groups differed significantly on the basis of the stratified log-rank test. As expected, the majority of deaths occurred in patients with breast cancer non- screen-detected (p < 0.0001).
Outcome and type of events that occurred in women, aged 50–69 years, with breast cancer diagnosed between 1996 and 2000 in the Province of Modena by screening status
Non screen-detected n(%)
Lost at follow-up
SECOND BREAST CANCER
BREAST CANCER SPECIFIC DEATH
OTHER SECOND MALIGNANCIES
DEATH FROM OTHER CAUSES
Factors with independent prognostic value of survival
DIAGNOSIS INSIDE MSP
The present study has shown that breast cancers detected through MSP are usually diagnosed at an early stage and are associated with a very favourable behaviour of the disease and an excellent prognosis, in terms of 5-year event-free survival and Overall Survival. Moreover, the study has also suggested that a population-based cancer registry is a relevant tool in the evaluation of a cancer screening program.
The decision to offer regular mammographic screening is based on the demonstration of reduced breast cancer-specific mortality in prospective randomized clinical trials [21–24]. In the randomized trials of breast screening, comparison of the prognostic profile of cancers detected in the invited as compared with the control groups has identified surrogate intermediate endpoints associated with the mortality reductions in those trials. These endpoints include such factors as the proportion of cancers smaller than 15 mm diameter or absence of lymph node involvement at diagnosis. It has been suggested that these intermediate endpoints might be useful to predict the likelihood that an organized breast screening program will achieve its mandate of mortality reduction on a population basis . The prognostic profile of screen-detected breast cancer within the MSP not only meets the targets derived from the randomized trials, but also demonstrates a significant advantage in terms of initial therapy and event-free survival when compared to other breast cancers diagnosed in the same geographically-defined population over the same time period.
In fact, since the beginning of the organized mammography screening program, an increasing proportion of women with newly diagnosed breast cancer each year (76 in 1996, 100 in 1997, 131 in 1998, 173 in 1999, 175 in 2000) have been MSP participants. The cancers diagnosed in women within four years of the screening program were histologically more favourable (GI-II, hormonal receptors positive, low proliferative activity), smaller (13 mm vs 19 mm) and less likely to have spread to axillary lymph nodes compared to breast cancer diagnosed out of the screening over the same time frame.
Since the crude breast cancer-specific mortality rate cannot be used for an immediate evaluation of the impact of screening mammography, we have used Event-Free Survival at 5 years as a measure of success of the MSP. We considered as events local or distant recurrence of breast cancer, second breast cancer, second cancer other than breast, and death from any cause. The rate of recurrences and second breast cancers, but not of other second malignancies or deaths, was significantly lower in the screen-detected group. As a consequence we observed a statistically significant and clinically meaningful 14% improvement in the 5-year event-free survival of women diagnosed by the MSP compared with those diagnosed out of the screening (89% vs. 75%). A difference was also observed in the subset of node negative tumors, where the 5-year survival rates are 95% in the screen-detected group and 91% in the non participants to the MSP. These results correlate with data from a recent study performed by Joensuu, in which a 5-year survival rate of 97% was observed in women with node negative tumors . In addition Joensuu and colleagues found a significant correlation between tumor size and prognosis. In fact, the 20-year survival rate was 93% for tumors of one cm or less, and only 75% for tumors of more than one cm in size. On the basis of that study we can predict that the excellent 5-year survival rate of 94% observed for tumors detected by the MSP (48% of which have a maximum diameter of one centimeter or less) will translate in a long term (i.e. 10 years) survival exceeding 90%.
Welch et al.  and Baum , state that 5-years survival rate is not sufficient to demonstrate the effectiveness of a screening program This period is considered too brief to by-pass the lead-time bias, that is the earlier detection of a breast cancer, which increases the survival from the time diagnosis to the time of death, without influencing the natural history of the disease. Calculating the 5-year survival rates after adjustment for lead-time and length bias confirmed our finding of a better prognosis of screen-detected cancers. The analysis of mean follow-up duration for every stage showed a superimposable period between the two groups, particularly for stage I BC, which were the most frequently detected cancers in the screen-detected group. Although the MSP seem sufficiently cost-effective, we have to realize that 29% of the tumours were not detected by screening. In fact, the MSP not only missed a small number of interval cancers (n = 34) but also did not cover the cancers occurring in patients excluded for screening because of a recent mammogram outside the MSP (n = 56) and in women who refused to participate in the screening program. Our results confirm that the characteristics of interval cancers are intermediate, between screen and non-screen detected tumors, in terms of size (17.7 mm), nodal status (24% positive), hormonal receptors (70% positive) and high proliferative activity (34%). Overall the sensitivity of our screening program, considered as a proportion of screen-detected cancers in all cancers diagnosed in the target population was 55%. However, the performance of the MSP compares favourably with the recommendations of the European Commission for quality assurance in mammography screening , which indicate a good detection rate at the first round when it is more than 3.5 fold of the incidence rate before the screening (2.6%0) and more than 1.5 fold at the subsequent rounds. Finally, we exclude that a class bias could have influenced our results since the number of women belonging to a low social class in the province of Modena according to the Statistic Service is very low (0.83%). Even though there is no direct information on social class status of population invited to the MSP, in an interview performed for a cervical screening program in Modena province, no differences between women belonging to a high or low social class in terms of participation to the study were found. In fact almost all women participated in the study, whereas in many other countries only women from the higher socioeconomic and educational strata are more likely to accept the invitation to screen and to participate in other health-promoting patterns of behaviour .
Our data clearly show that the major cause for the decreasing breast cancer mortality is the smaller tumour size, associated with the earlier detection by the MSP. Moreover, the chemotherapy was not retained as an independent prognostic factor, confirming that the magnitude of impact of chemotherapy is very likely less relevant compared to the effect of early detection. Despite that, in our series of screen-detected breast cancers, a very high rate of patients were treated with chemotherapy, even if the most used regimen was CMF.
Finally, we would remark that our study was made possible and facilitated only by the existence of a population-based cancer registry in the area. Through the registry we recognized all new cases of cancers in women aged 50–69 years and achieved information on follow-up status. We consider a cancer registry an important tool for an adequate monitoring of the screening programs.
In conclusion, our data show the effectiveness of the MSP in terms of early diagnosis, more favorable behaviour of the tumor and better prognosis, even if only 65% of the age-eligible female were partecipating in this program in 1996–2000. This analysis has pointed out the need and potential value of substantially increasing recruitment to the MSP to 70% or more, as achieved in other geographic areas.
We thank E. Artioli, K.Valla, supported by the Modena Cancer Registry and B.Braghiroli, supported by grants from Associazione Angela Serra per la Ricerca sul Cancro, for their help in data collection and management.
The study was also supported by grants from Regione Emilia-Romagna, and MIUR-Cofin2003.
- Parkin DM, Pisani P, Ferlay J: Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer. 1999, 80: 827-841. 10.1002/(SICI)1097-0215(19990315)80:6<827::AID-IJC6>3.0.CO;2-P.View ArticlePubMedGoogle Scholar
- Veronesi U, Paganelli G, Viale G, Luini A, Zurrida S, Galimberti V, Intra M, Veronesi P, Robertson C, Maisonneuve P, Renne G, De Cicco C, De Lucia F, Gennari R: A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. N Engl J Med. 2003, 349: 546-553. 10.1056/NEJMoa012782.View ArticlePubMedGoogle Scholar
- Silverstein MJ, Gamagami P, Masetti R, Legmann MD, Craig PH, Gierson ED: Results from a multidisciplinary breast center. Analysis of disease discovered. Surg Oncol Clin N Am. 1997, 6: 301-314.PubMedGoogle Scholar
- Miller BA, Ries LAG, Hankey BF: Cancer Statistics Review:1973-1989. MD:National Cancer Institute. 1992, Bethesda, NIH publication, 92-2789:Google Scholar
- Shapiro S, Strax P, Venet L: Periodic breast cancer screening in reducing mortality from breast cancer. Jama. 1971, 215: 1777-1785. 10.1001/jama.215.11.1777.View ArticlePubMedGoogle Scholar
- Andersson I: Breast cancer screening in Malmo. Recent Results Cancer Res. 1984, 90: 114-116.View ArticlePubMedGoogle Scholar
- Duffy SW, Tabar L, Fagerberg G, Gad A, Grontoft O, South MC, Day NE: Breast screening, prognostic factors and survival--results from the Swedish two county study. Br J Cancer. 1991, 64: 1133-1138.View ArticlePubMedPubMed CentralGoogle Scholar
- Lidbrink EK, Tornberg SA, Azavedo EM, Frisell JO, Hjalmar ML, Leifland KS, Sahlstedt TB, Skoog L: The general mammography screening program in Stockholm. Organisation and first-round results. Acta Oncol. 1994, 33: 353-358.View ArticlePubMedGoogle Scholar
- Regner H: Screening for breast cancer with mammography in Bohuslan County, Sweden. Recent Results Cancer Res. 1990, 119: 60-64.View ArticlePubMedGoogle Scholar
- Nystrom L, Andersson I, Bjurstam N, Frisell J, Nordenskjold B, Rutqvist LE: Long-term effects of mammography screening: updated overview of the Swedish randomised trials. Lancet. 2002, 359: 909-919. 10.1016/S0140-6736(02)08020-0.View ArticlePubMedGoogle Scholar
- Alexander FE, Anderson TJ, Brown HK, Forrest AP, Hepburn W, Kirkpatrick AE, Muir BB, Prescott RJ, Smith A: 14 years of follow-up from the Edinburgh randomised trial of breast-cancer screening. Lancet. 1999, 353: 1903-1908. 10.1016/S0140-6736(98)07413-3.View ArticlePubMedGoogle Scholar
- Andersson I, Aspegren K, Janzon L, Landberg T, Lindholm K, Linell F, Ljungberg O, Ranstam J, Sigfusson B: Mammographic screening and mortality from breast cancer: the Malmo mammographic screening trial. Bmj. 1988, 297: 943-948.View ArticlePubMedPubMed CentralGoogle Scholar
- Tabar L, Fagerberg G, Day NE, Duffy SW, Kitchin RM: Breast cancer treatment and natural history: new insights from results of screening. Lancet. 1992, 339: 412-414. 10.1016/0140-6736(92)90090-P.View ArticlePubMedGoogle Scholar
- Kerlikowske K, Grady D, Rubin SM, Sandrock C, Ernster VL: Efficacy of screening mammography. A meta-analysis. Jama. 1995, 273: 149-154. 10.1001/jama.273.2.149.View ArticlePubMedGoogle Scholar
- Peeters PH, van Noord PA, Hoes AW, Grobbee DE: Hypertension, antihypertensive drugs, and mortality from cancer among women. J Hypertens. 1998, 16: 941-947. 10.1097/00004872-199816070-00007.View ArticlePubMedGoogle Scholar
- Galper S, Blood E, Gelman R, Abner A, Recht A, Kohli A, Wong JS, Smith D, Bellon J, Connolly J, Schnitt S, Winer E, Silver B, Harris JR: Prognosis after local recurrence after conservative surgery and radiation for early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2005, 61: 348-357. 10.1016/j.ijrobp.2004.06.011.View ArticlePubMedGoogle Scholar
- Fortin A, Larochelle M, Laverdiere J, Lavertu S, Tremblay D: Local failure is responsible for the decrease in survival for patients with breast cancer treated with conservative surgery and postoperative radiotherapy. J Clin Oncol. 1999, 17: 101-109.PubMedGoogle Scholar
- van Dongen JA, Voogd AC, Fentiman IS, Legrand C, Sylvester RJ, Tong D, van der Schueren E, Helle PA, van Zijl K, Bartelink H: Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst. 2000, 92: 1143-1150. 10.1093/jnci/92.14.1143.View ArticlePubMedGoogle Scholar
- Sobin LH, Wittekind CH: International Union Against Cancer. TNM Classification of Malignant Tumours. Edited by: ed . 1997, New York, WileyGoogle Scholar
- Turchetti D, Mangone L, Negri R, Rossi G, Cortesi L, Vinceti M, Maiorana A, Gallo E, Federico M: Changes in breast cancer incidence and stage distribution in Modena, Italy: the effect of a mammographic screening program. Cancer Causes Control. 2002, 13: 729-734. 10.1023/A:1020208719902.View ArticlePubMedGoogle Scholar
- Larsson LG, Andersson I, Bjurstam N, Fagerberg G, Frisell J, Tabar L, Nystrom L: Updated overview of the Swedish Randomized Trials on Breast Cancer Screening with Mammography: age group 40-49 at randomization. J Natl Cancer Inst Monogr. 1997, 57-61.Google Scholar
- Nystrom L, Rutqvist LE, Wall S, Lindgren A, Lindqvist M, Ryden S, Andersson I, Bjurstam N, Fagerberg G, Frisell J, et al: Breast cancer screening with mammography: overview of Swedish randomised trials. Lancet. 1993, 341: 973-978. 10.1016/0140-6736(93)91067-V.View ArticlePubMedGoogle Scholar
- Kerlikowske K: Efficacy of screening mammography among women aged 40 to 49 years and 50 to 69 years: comparison of relative and absolute benefit. J Natl Cancer Inst Monogr. 1997, 79-86.Google Scholar
- Hendrick RE, Smith RA, Rutledge JH, Smart CR: Benefit of screening mammography in women aged 40-49: a new meta-analysis of randomized controlled trials. J Natl Cancer Inst Monogr. 1997, 87-92.Google Scholar
- Sickles EA: Breast cancer screening outcomes in women ages 40-49: clinical experience with service screening using modern mammography. J Natl Cancer Inst Monogr. 1997, 99-104.Google Scholar
- Joensuu H, Pylkkanen L, Toikkanen S: Late mortality from pT1N0M0 breast carcinoma. Cancer. 1999, 85: 2183-2189. 10.1002/(SICI)1097-0142(19990515)85:10<2183::AID-CNCR12>3.0.CO;2-K.View ArticlePubMedGoogle Scholar
- Welch HG, Schwartz LM, Woloshin S: Are increasing 5-year survival rates evidence of success against cancer?. Jama. 2000, 283: 2975-2978. 10.1001/jama.283.22.2975.View ArticlePubMedGoogle Scholar
- Baum M: Breast cancer screening comes full circle. J Natl Cancer Inst. 2004, 96: 1490-1491.View ArticlePubMedGoogle Scholar
- M.Rosselli del Turco JHNP: Radiological guidelines for quality assurance in mammography screening. European guidelines for quality assurance in mammography screening. Edited by: N.Perry MBCWST. 2001, Bruxelles, European Commission office for ufficial pubblications, 143-158.Google Scholar
- Kaffashian F, Godward S, Davies T, Solomon L, McCann J, Duffy SW: Socioeconomic effects on breast cancer survival: proportion attributable to stage and morphology. Br J Cancer. 2003, 89: 1693-1696. 10.1038/sj.bjc.6601339.View ArticlePubMedPubMed CentralGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/6/17/prepub
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